Patents by Inventor Kei Fujinaga
Kei Fujinaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080044903Abstract: Improved methods for transferring a gene into target cells by using a retrovirus, wherein the gene transfer efficiency is improved and the target cells are efficiently transformed by binding the retrovirus to a functional substance which is immobilized on as carrier and having an activity of binding to retroviruses followed by washing; using an antibody capable of specifically recognizing cells, laminin or mannose-rich type sugar chain as a substance having an activity of binding to the target cells; pre-treating the target cells so as to inactivate transferring receptor, or introducing a new functional group into the functional substance.Type: ApplicationFiled: July 27, 2007Publication date: February 21, 2008Applicants: Takara Shuzo Co., Ltd., TAKARA BIO INC.Inventors: Mitsuhiro UENO, Hirofumi Yoshioka, Haruko Konishi, Kimikazu Hashino, Mio Morishita, Hideto Chono, Tsuyoshi Miyamura, Mutsumi Sano, Kiyozo Asada, Kei Fujinaga, Ikunoshin Kato
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Publication number: 20070160585Abstract: It is intended to provide a drug which is efficacious in treating a prion disease and has a high safety. A remedy for a prion disease which contains a mesenchymal stem cell as the active ingredient and a method of producing the same. A remedy for a prion disease which contains a mesenchymal stem cell, in particular, a mesenchymal stem cell having an anti-prion antibody gene transferred thereinto as the active ingredient and a method of producing the same. These remedies can not only prevent the progress of a prion disease but also contribute to the recovery of nerve dysfunction caused by the disease.Type: ApplicationFiled: March 30, 2005Publication date: July 12, 2007Inventors: Kei Fujinaga, Morikazu Shinagawa, Yoshiro Niitsu, Hirofumi Hamada, Motohiro Horiuchi, Osamu Honmou, Atsushi Umetani
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Patent number: 7070931Abstract: Clarification of the relationship between the functions of E1AF gene and the invasion and metastasis of cancers, and application thereof to cancer control, more specifically the control of cancer cell invasion by controlling the expression of E1AF gene and the products of expression, and the detection and diagnosis of cancers by detecting the products of expression of E1aF gene.Type: GrantFiled: June 13, 2002Date of Patent: July 4, 2006Assignee: Takara Bio Inc.Inventors: Kei Fujinaga, Koichi Yoshida, Fumihiro Higashino
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Patent number: 6995010Abstract: A method of transferring a foreign gene into cells, characterized by involving: the step of transferring into the cells with the use of an adenovirus vector, a first nucleic acid, which has a sequence provided with adeno-associated virus-origin ITRs in both sides of the target foreign gene to be transferred, and a second nucleic acid, which has an adeno-associated virus-origin rep gene and a promoter for expressing this gene and carries a stuffer sequence inserted thereinto sandwiched in two recombinase recognition sequences and located between the rep gene and the promoter; and the step of expressing the Rep protein under the action of recombinase in the cells obtained in the above step to thereby integrate the target foreign gene into the chromosomal DNA.Type: GrantFiled: October 23, 2000Date of Patent: February 7, 2006Assignee: Takara Bio Inc.Inventors: Takashi Ueno, Hajime Matsumura, Keiji Tanaka, Tomoko Iwasaki, Mitsuhiro Ueno, Kei Fujinaga, Kiyozo Asada, Ikunoshin Kato
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Patent number: 6787359Abstract: Improved methods for transferring a gene into target cells by using a retrovirus, wherein the gene transfer efficiency is improved and the target cells are efficiently transformed by binding the retrovirus to a functional substance which is immobilized on as carrier and having an activity of binding to retroviruses followed by washing; using an antibody capable of specifically recognizing cells, laminin or mannose-rich type sugar chain as a substance having an activity of binding to the target cells; pre-treating the target cells so as to inactivate transferrin receptor, or introducing a new functional group into the functional substance.Type: GrantFiled: January 9, 2001Date of Patent: September 7, 2004Assignee: Takara Shuzo Co., Ltd.Inventors: Mitsuhiro Ueno, Hirofumi Yoshioka, Haruko Konishi, Kimikazu Hashino, Mio Morishita, Hideto Chono, Tsuyoshi Miyamura, Mutsumi Sano, Kiyozo Asada, Kei Fujinaga, Ikunoshin Kato
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Publication number: 20040058447Abstract: Improved methods for transferring a gene into target cells by using a retrovirus, wherein the gene transfer efficiency is improved and the target cells are efficiently transformed by binding the retrovirus to a functional substance which is immobilized on as carrier and having an activity of binding to retroviruses followed by washing; using an antibody capable of specifically recognizing cells, laminin or mannose-rich type sugar chain as a substance having an activity of binding to the target cells; pre-treating the target cells so as to inactivate transferrin receptor, or introducing a new functional group into the functional substance.Type: ApplicationFiled: September 9, 2003Publication date: March 25, 2004Applicant: Takara Shuzo Co., Ltd.Inventors: Mitsuhiro Ueno, Hirofumi Yoshioka, Haruko Konishi, Kimikazu Hashino, Mio Morishita, Hideto Chono, Tsuyoshi Miyamura, Mutsumi Sano, Kiyozo Asada, Kei Fujinaga, Ikunoshin Kato
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Publication number: 20030087862Abstract: Clarification of the relationship between the functions of E1AF gene and the invasion and metastasis of cancers, and application thereof to cancer control, more specifically the control of cancer cell invasion by controlling the expression of E1AF gene and the products of expression, and the detection and diagnosis of cancers by detecting the products of expression of E1aF gene.Type: ApplicationFiled: June 13, 2002Publication date: May 8, 2003Applicant: Takara Shuzo Co., Ltd.Inventors: Kei Fujinaga, Koichi Yoshida, Fumihiro Higashino
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Patent number: 6528310Abstract: Clarification of the relationship between the functions of E1AF gene and the invasion and metastasis of cancers, and application thereof to cancer control, more specifically the control of cancer cell invasion by controlling the expression of E1AF gene and the products of expression, and the detection and diagnosis of cancers by detecting the products of expression of E1aF gene.Type: GrantFiled: June 23, 2000Date of Patent: March 4, 2003Assignee: Takara Shuzo Co., Ltd.Inventors: Kei Fujinaga, Koichi Yoshida, Fumihiro Higashino
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Patent number: 6096542Abstract: Clarification of the relationship between the functions of E1AF gene and the invasion and metastasis of cancers, and application thereof to cancer control, more specifically the control of cancer cell invasion by controlling the expression of E1AF gene and the products of expression, and the detection and diagnosis of cancers by detecting the products of expression of E1AF gene.Type: GrantFiled: August 7, 1997Date of Patent: August 1, 2000Assignee: Takara Shuzo Co., Ltd.Inventors: Kei Fujinaga, Koichi Yoshida, Fumihiro Higashino