Abstract: Devices, systems and methods are provided for cutting the skin, accessing and collecting physiological sample therein, and measuring a characteristic (e.g., an analyte concentration, of the sampled physiological sample). The subject devices are in the form of a tester or test element which includes a biosensor and preferably only one blade member that is removed in location from the biosensor. The placement of the blade or micro-blade element may vary, but is most preferably located to provide clearance from a user's finger during biological sample collection in connection with the biosensor. The testers are preferably configured to be stacked in a magazine for successive firing by a meter configured to automatically actuate sample acquisition and reading. Systems and methods in connection with the subject testers are also provided.

Abstract: An isolation fluid control device and water cup for use in an automated, random-access, isolation fluid-based, analytical instrument. The cup, in operation, contains two immiscible liquids. The cup is provided with inlets and outlets, and additionally comprises a liquid level control structure and structure operable to permit passage of one liquid therethrough to the substantial exclusion of the other liquid.