Abstract: The present invention provides medicinal compositions characterized by comprising as the active ingredient either a compound represented by a formula [I] or a pharmaceutically acceptable composite thereof; [wherein X represents oxygen or sulfur; R1 represents e.g., C1-4 alkyl, phenyl optionally substituted, etc.; Q1 represents spacer consisted of 0 to 3 carbon atoms; R2 represents, e.g., phenyl optionally substituted; R3 represents, e.g., hydrogen, C1-4 alkyl, or a group represented by the following formulae; —CONH—R6; R4 and R5 represent e.g., nitro, cyano, C1-4 alkylcarbonyl, respectively]; in particular, medicine which is useful as therapeutic and/or protective drugs for inflammatory diseases and/or allergic diseases by improving sick conditions accompanied with the stimulated phospholipase A(2) activity.

Abstract: A compound represented by the formula [I]: [I] (wherein X represents oxygen, sulfur, NR4, or CHR5; Y represents oxygen or sulfur; R1 represents C1-6 alkyl, etc.; R2 represents optionally substituted phenyl, etc.; and R3 represents optionally substituted C1-6 alkyl, a group represented by any of the following formulae, etc.) [II] or a pharmaceutically acceptable composite of the compound; a medicinal composition containing any of these as an active ingredient; and a use thereof, etc.

Abstract: The present invention provides medicinal compositions characterized by containing as the active ingredient either a compound represented by a general formula (1) or a pharmaceutically acceptable composite thereof, 1

Abstract: The present invention provides medicinal compositions characterized by comprising as the active ingredient either a compound represented by a formula [I] or a pharmaceutically acceptable composite thereof; 1

Abstract: The present invention provides medicinal compositions characterized by containing as the active ingredient either a compound represented by a general formula (1) or a pharmaceutically acceptable composite thereof, [wherein X represents oxygen or sulfur; R1 represents hydrogen, C1-4 alkyl, etc.; R2 represents, e.g., phenyl optionally substituted by A1; R3 represents, e.g., hydrogen, C1-4 alkyl optionally substituted by A2, or a group represented by either one of the following formulae; R represents oxygen, sulfur, or a group represented by a formula (N—G)], in particular, inhibitors of phospholipase A(2) activity; use of the compositions; and compounds represented by a general formula (1—1); wherein X, R1, R2, R3 and G1 are the same as defined in the description.

Abstract: The present invention provides medicinal compositions characterized by containing as the active ingredient either a compound represented by a general formula (1) or a pharmaceutically acceptable composite thereof, 1

Abstract: An insecticidal compound of the formula ##STR1## wherein A completes a 5 or 6 membered aromatic ring selected from the group pyridyl, pyridyl substituted with C.sub.1-5 alkyl, C.sub.1-5 haloalkyl, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio, C.sub.1-5 alkylsulfonyl, cyano, halogen, phenoxy or C.sub.1-5 dialkylamino, pyrazinyl, pyrazinyl substituted with C.sub.1-5 alkyl or halogen, pyrazolyl substitited with C.sub.1-5 alkyl, pyridazyl substituted with halogen, or thiazolyl substituted with halogen or C.sub.1-5 alkyl;R.sub.1 is hydrogen or C.sub.1-5 alkyl, C.sub.1-5 haloalkyl, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio, C.sub.1-5 alkylsulfonyl, cyano, halogen, phenoxy, or C.sub.1-5 dialkylamino;X is substituted or unsubstituted C.sub.1-3 alkylene or C.sub.1-3 alkylidene;R.sub.2 is hydrogen, monoalkylcarbamoyl, C.sub.1-5 dialkylcarbamoyl, C.sub.1-5 alkoyl, C.sub.1-5 alkyl substituted with halogen, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio, C.sub.1-5 alkoxycarbonyl, cyano, aryl, haloaryl, C.sub.

Abstract: The present invention relates to a compound having the formula below which has an excellent inseciticidal activity: ##STR1## wherein R.sub.1 represents an optionally substituted 5-6 membered aromatic hetero ring containing nitrogen atom, except a non-substituted 2-pyridyl; x represents an optionally substituted C.sub.1-3 alkyleneR.sub.2 represents a hydrogen, a carbamoyl, a mono or di C.sub.1-5 alkyl carbamoyl, a thiocarbamoyl, a mono or di C.sub.1-5 alkylthiocarbamoyl, a sulfamoyl, a mono or di C.sub.1-5 alkylsulfamoyl, an optionally substituted C.sub.1-5 alkyl, an optionally substituted C.sub.2-5 alkenyl, an optionally substituted C.sub.2-5 alkynyl, an optionally substituted C.sub.3-8 cycloalkyl, an optionally substituted C.sub.3-8 cycloalkenyl, an optionally substituted aryl or --Y--R.sub.5 ;Y represents O, S(O).sub.n, CO, CS or CO.sub.2 ;n represents 0, 1 or 2;R.sub.5 represents a hydrogen, an optionally substituted C.sub.1-5 alkyl, an optionally substituted C.sub.2-5 alkenyl, an optionally substituted C.

Abstract: The present invention relates to a compound having the formula ##STR1## wherein R.sub.1 denotes C.sub.1-6 alkyl radicals; R.sub.2 denotes halogen atoms, C.sub.1-6 alkyl radicals, C.sub.1-6 haloalkyl radicals, C.sub.1-6 alkoxy radicals, C.sub.1-6 haloalkoxy radicals or the phenyl radicals which may be substituted by methylenedioxy radicals; ##STR2## denotes 5-7 member heterocyclic radicals whose ring constituent atoms comprise 2-6 carbon atoms, 0-1 oxygen atom and 1-2 nitrogen atoms and which may be substituted by C.sub.1-6 alkyl radicals.

Abstract: The present invention relates to a compound having the formula ##STR1## wherein R.sub.1 denotes C.sub.1-6 alkyl radicals; R.sub.2 denotes halogen atoms, C.sub.1-6 alkyl radicals, C.sub.1-6 haloalkyl radicals, C.sub.1-6 alkoxy radicals, C.sub.1-6 haloalkoxy radicals or the phenyl radicals which may be substituted by methylenedioxy radicals; ##STR2## denotes 5-7 member heterocyclic radicals whose ring constituent atoms comprise 2-6 carbon atoms, 0-1 oxygen atom and 1-2 nitrogen atoms and which may be substituted b C.sub.1-6 alkyl radicals, are processes and an acaricidal composition comprising its compound as active ingredient(s).

Abstract: Isovaleric acid derivatives having the formula ##STR1## wherein typical representations of X is halophenyl, R.sub.1 is hydrogen or cyano, R.sub.2 is hydrogen or lower alkyl, and Y is halophenyl. These derivatives possess insecticidal and acaricidal properties. The process for their preparation is described.