Abstract: A linear vibration motor is provided that includes a housing, a vibrator, and a coil. The vibrator includes a weight portion and a first magnet, and the vibrator is accommodated inside the housing. The weight portion includes a multilayer body in which multiple sheets including metal sheets are laminated in a thickness direction. The multilayer body has a first principal surface and a second principal surface opposite to the first principal surface, and a first accommodation section is formed in the multilayer body so as to open at the first principal surface and at the second principal surface. The first magnet is fixed in the first accommodation section and the coil is fixed to the housing so as to oppose the first magnet. In addition, an electronic device is provided that uses the linear vibration motor. A vibrator and a method of manufacturing the vibrator is also provided.

Abstract: The present invention provides an immunopotentiating composition which comprises an antigen or antigen-inducing substance, and a carrier comprising a biocompatible material for effectively increasing an immune response derived from an antigen. The present invention further provides a method of producing an antibody by administering said immunopotentiating composition to a mammal or bird, thereby modulating the immune response in said mammal or bird and recovering the antibody produced.

Abstract: A construction machine having an oil cooler 3, a radiator 4, and a fan shroud 5 arranged in an upper rotating body 13, in which the oil cooler 3 and the fan shroud 5 are securely fixed to the upper rotating body 13 and the radiator 4 is adapted to be detachably fixed to the upper rotating body 13 while the oil cooler 3 and the fan shroud 5 are held in the state fixed to the upper rotating body 13.

Abstract: An air intake structure in a construction machine, comprising a radiator chamber, a radiator ventilating hole formed in an upper position of the radiator chamber, an air cleaner chamber formed in close proximity to the radiator chamber, an air cleaner ventilating hole formed in the ceiling surface of the air cleaner chamber, an intake duct disposed below the air cleaner ventilating hole and communicating with the radiator chamber, and an air cleaner disposed in close proximity to the ceiling surface of the air cleaner chamber at a position close to the intake duct. According to this air intake structure, not only the engine cooling efficiency can be enhanced to a satisfactory extent, but also a lower space in the air cleaner chamber can be fully utilized effectively.

Abstract: A drug formulation for producing sustained therapeutic efficacy, which releases at least one water-soluble drug over a prolonged period of time at a substantially constant rate wherein said drug formulation comprises(a) a nondisintegrating inner layer comprised of a biocompatible material that contains at least one uniformly dispersed water-soluble drug; and(b) an outer layer comprised of a biocompatible material that surrounds the circumference of the said inner layer, is impermeable to water, and is capable of controlling the swelling of the inner layer; wherein the ratio of the axial length of the drug formulation to the cross-sectional diameter of the inner layer is one or more and wherein one or both ends of the inner layer are open so as to come into direct contact with the external environment.

Abstract: Equipment for intracerebral administration of preparations is composed of a preparation-administering device (1) holding a preparation (2), and a plunger (4) removably arranged in the preparation-administering device adapted to push the preparation held therein toward one end of the preparation-administering device. The intracerebral preparation-administration equipment is inserted into a preparation-introducing guide (5) previously implanted in the head of a patient to introduce the preparation into its guide hole (26). The preparation is then guided to a site of administration through a flexible guide tube (23) communicated with the guide hole of the preparation-introducing guide. The equipment for intracerebral administration of preparations may be composed of a tubular preparation-retaining member (30) having a preparation contained therein, and a holder (32) for holding the tubular preparation-retaining member along with a push rod (31) inserted thereinto as an integral part thereof.

Abstract: A method of measuring the activity of interferon-.alpha., .beta. or .omega., which comprises bringing a sample containing interferon into contact with a cell and determining an induced protein is provided.

Abstract: A solid formulation for buccal or oral administration which contains a proteinaceous physiologically active substance as an active ingredient, as well as collagen and a water-soluble additive, said formulation being characterized by being porous and having a good disintegration property, and a preparation thereof are provided.

Abstract: The present invention relates to a sustained-release injection, which comprises a suspension of a powder comprising an active ingredient and a pharmaceutically acceptable biodegradable carrier (e.g. proteins, polysaccharides and synthetic high molecular compounds, preferably collagen, atelocollagen, gelatin, and a mixture thereof) in a viscous solvent for injection (e.g. vegetable oils, polyethylene glycol, propylene glycol, silicone oil, and medium-chain fatty acid triglycerides). The sustained-release injection can release the active ingredient at an effective level for a long period of time when injected.

Abstract: A controlled release formulation which comprises a compound selected from the group consisting of organic acidic compounds and acid anhydrides or esters capable of generating one of the organic acidic compounds through hydrolysis together with an active ingredient and collagen as a carrier, said formulation being capable of exhibiting a predetermined release profile of the active ingredient. A process for producing said formulation is also provided.

Abstract: A preparation administrator has an administrator body including a solid preparation and having at its one end an inflow channel for solvent and at the other end an outflow channel for liquid preparation, a solvent container containing a solvent to dissolve, disperse or suspend the preparation and being connected to the inflow channel of the administrator body, and an ejector for ejecting the solvent together with the solid preparation in the body through the outflow channel of the body. A solid preparation in the administrator body is dissolved, or suspended or dispersed in the solvent fed from the solvent container and ejected as a liquid preparation through the outflow channel of the body.

Abstract: A method for drying a wetted molded product of pasty high viscous composition which comprises subjecting the molded product to a dehydration process while wholly or partially contacting the product with an open-cell foamed hydrophobic porous membrane.

Abstract: A sustained-release preparation of indomethacin or interferon comprising the active ingredient in admixture with a pharmaceutically acceptable biodegradable carrier, particularly a carrier selected from collagen, gelatin, and a mixture thereof. Said preparation is particularly suitable for parenteral administration and can release the active ingredient in an effective amount for a long period of time.

Abstract: A solid sustained-release preparation in the form of a needle-like or bar-like shape, which consists essentially of an active ingredient and a pharmaceutically acceptable biodegradable carrier (e.g. proteins, preferably collagen, gelatin, and a mixture thereof). The sustained release preparation can be administered to the body or implanted into the body by injection or an injection-like method and can release the active ingredient at an effective level for a long period of time when administered.

Abstract: The invention relates to sustained pulsewise release pharmaceutical preparation which comprices drug-containing polymeric material layers (layers A) and polymeric material layers containing the drug in question only in a slight amount or free of the drug (layers B) disposed alternatingly, with the whole surface extending in the direction perpendicular to the layer plane being coated with a polymeric material which is insoluble in water or scarcely soluble in water (polymeric material C).This pharmaceutical preparation of this invention is designed so that active ingredients which should desirably be released pulsewise can be released therefrom in a pulse-like and clinically significant manner and thereby the pharmacological effects of said active ingredients can be maintained for a prolonged period of time.

Abstract: A sustained release composition applicable for human beings and mammals which comprises (a) a silicone elastomer and (b) a pharmaceutical substance optionally with (c) albumin. When the pharmaceutical substance is of high molecular weight, and can exert its pharmaceutical effect in a trace amount, its continuous release over a long period is attained by application of this invention.

Abstract: Growth hormone releasing factor (GRF) preparation which is excellent in stablity by having human serum albumin or glycine incorporated therein, with or without buffer. An amount of human serum albumin or glycine contained is usually 100 .mu.g to 30 mg per 100 .mu.g GRF. The preparation may be in the solid or solution form, preferably in the lyophilized form. An amount of buffer, if added, is preferably enough so that pH of the preparation is kept at 2-7. More preference is that the preparation is kept in nitrogen gas atmosphere. The lyophilized preparation is readily usable for, for example, injection.

Abstract: A device for administering solid or semisolid preparations in an organism subcutaneously. The equipment comprises a barrel having a nozzle for attachment of a hollow needle, a plunger slidably arranged in the barrel and is used in combination with a guide member adapted to be snugly accommodated within the lumen of the barrel. The solid preparations are generally housed in the guide member and/or needle and forced into the body subcutaneously through the needle.

Abstract: A device for administering solid or semisolid preparations under the skin, which comprises a solid needle member with an acute tip end, and a cylindrical member slidably mounted on the needle member. The solid needle member having a recess at its front part to form a preparation chamber between the needle member and cylindrical member, and the chamber being opened or closed by moving the cylindrical member in the direction parallel to the axis of the needle member. The device may comprises a cylindrical member with a capsule chamber, a hollow needle member removable mounted on the front end of the cylindrical member, and a plunger slidably arranged in the capsule chamber of the cylindrical member, all of which have a common axis so that the plunger enters into the hollow needle member through the capsule chamber.

Abstract: An antimicrobial preparation of D-7-[.alpha.-(4-hydrooxy-6-methylnicotinamido)-4-hydroxyphenylacetamido]-3 -(1-methyltetrazol-5-yl)thiomethyl-.DELTA..sup.3 -cephem-4-sodium carboxylate (hereinafter referred to as "Compound A" of enhanced stability is disclosed, which comprises a microbially effective amount of Compund A and a stabilizer selected from the class consisting of benzoic acid, sodium benzoate and nicotinamide.