Patents by Inventor Keiji Iwamoto
Keiji Iwamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11981686Abstract: An object of the present invention is to provide a compound that has a specific chemical structure having an activation effect on SIRT6 and is useful as an active component for preventing and treating inflammatory diseases, and the present invention relates to a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof, where each symbol in Formula (1) has the same definition as that described in the specification.Type: GrantFiled: January 23, 2020Date of Patent: May 14, 2024Assignee: DAIICHI SANKYO COMPANY, LIMITEDInventors: Junya Kawai, Osamu Iwamoto, Yuma Umezaki, Katsuyoshi Nakajima, Hiroyuki Tsuruoka, Keiji Saito, Nobuya Kurikawa, Natsumi Nishihama, Shinji Tanaka, Momoko Ogitani, Tomohiro Honda, Wataru Saitoh, Tsuyoshi Soneda, Nobuyuki Ohkawa
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Publication number: 20240150309Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.Type: ApplicationFiled: November 3, 2023Publication date: May 9, 2024Applicant: Daiichi Sankyo Company, LimitedInventors: Keiji Saito, Katsuyoshi Nakajima, Toru Taniguchi, Osamu Iwamoto, Satoshi Shibuya, Yasuyuki Ogawa, Kazumasa Aoki, Nobuya Kurikawa, Shinji Tanaka, Momoko Ogitani, Eriko Kioi, Kaori Ito, Natsumi Nishihama, Tsuyoshi Mikkaichi, Wataru Saitoh
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Patent number: 11819779Abstract: A chromatographic separation method for separating plural components contained in a liquid to be separated by a chromatography, with a separating device 1 including plural filling portions 10 filled with a separating agent for separating the plural components contained in the liquid to be separated, a supply portion 20 provided in each of the plural filling portions 10 to supply the liquid to be separated or an eluent for extracting any component contained in the liquid to be separated to the filling portion 10, and an extraction portion 30 to extract any component contained in the liquid to be separated from the filling portion 10, the method including: an upward supplying and extracting step of extracting any component contained in the liquid to be separated from an upward stream extraction portion while supplying the eluent to at least one filling portion 10 from an upward stream supply portion by an upward stream.Type: GrantFiled: February 28, 2019Date of Patent: November 21, 2023Assignee: Mitsubishi Chemical Aqua Solutions Co., Ltd.Inventors: Keiji Iwamoto, Makoto Yasumoto, Toshihiko Uratsuji
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Publication number: 20210330802Abstract: The present invention provides a method for producing an antibody-drug conjugate (ADC) comprising an antibody and a drug linked to each other via a linker. The present invention provides a method for producing, for example, an antibody-drug conjugate (ADC) comprising an antibody and a drug linked to each other via a linker, or a pharmaceutical comprising the ADC, the method comprising mixing, using a microreactor, a solution comprising tricarboxyethyl phosphine (TCEP) and an IgG antibody under reduction reaction with TCEP, with a solution comprising a stoichiometrically excessive amount of an inhibitor of TCEP based on TCEP.Type: ApplicationFiled: October 10, 2019Publication date: October 28, 2021Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Masato SUENAGA, Kosuke TAKENAKA, Keiji IWAMOTO
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Publication number: 20210039014Abstract: A chromatographic separation method for separating plural components contained in a liquid to be separated by a chromatography, with a separating device 1 including plural filling portions 10 filled with a separating agent for separating the plural components contained in the liquid to be separated, a supply portion 20 provided in each of the plural filling portions 10 to supply the liquid to be separated or an eluent for extracting any component contained in the liquid to be separated to the filling portion 10, and an extraction portion 30 to extract any component contained in the liquid to be separated from the filling portion 10, the method including: an upward supplying and extracting step of extracting any component contained in the liquid to be separated from an upward stream extraction portion while supplying the eluent to at least one filling portion 10 from an upward stream supply portion by an upward stream.Type: ApplicationFiled: February 28, 2019Publication date: February 11, 2021Applicant: Mitsubishi Chemical Aqua Solutions Co., Ltd.Inventors: Keiji IWAMOTO, Makato YASUMOTO, Toshihiko URATSUJI
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Patent number: 10479917Abstract: The present invention addresses the problem of providing a water-soluble cutting or grinding fluid that has excellent permeability and washability, that can be widely used in cutting or grinding, and that is particularly suitable for use in superfinishing. The present invention provides a water-soluble cutting or grinding fluid that contains a glycol compound (A), at least one substance (B) selected from the group consisting of organic amines and inorganic alkalis, a surfactant (C), and water (D), the water-soluble cutting or grinding fluid having a contact angle of 2 to 15° as measured using the ?/2 method one second after a drop of a dilution of the water-soluble cutting or grinding fluid is dropped on an SPCC-SB plate.Type: GrantFiled: May 28, 2014Date of Patent: November 19, 2019Assignee: NTN CorporationInventors: Masashi Kitai, Kohei Higashi, Hidekazu Hirano, Hajime Isa, Masanori Nishira, Hitoshi Shiotani, Keiji Iwamoto, Youhei Migaki
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Patent number: 9758623Abstract: The present invention relates to a polyimide precursor comprising a repeating unit represented by the following chemical formula (1): wherein A is a tetravalent group having at least one aliphatic six membered ring and no aromatic ring in the chemical structure, and B is a divalent group having at least one amide bond and an aromatic ring in the chemical structure; or A is an aliphatic tetravalent group and B is a divalent group having at least one chemical structure represented by the following chemical formula (2) in the chemical structure: and X1 and X2 are each independently hydrogen, a C1-6 alkyl group or a C3-9 alkylsilyl group.Type: GrantFiled: August 7, 2015Date of Patent: September 12, 2017Assignee: UBE INDUSTRIES, LTD.Inventors: Ryoichi Takasawa, Takuya Oka, Yukinori Kohama, Miharu Nakagawa, Keiji Iwamoto, Kenji Hirotsu, Yoshiyuki Watanabe
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Publication number: 20160108302Abstract: The present invention addresses the problem of providing a water-soluble cutting or grinding fluid that has excellent permeability and washability, that can be widely used in cutting or grinding, and that is particularly suitable for use in superfinishing. The present invention provides a water-soluble cutting or grinding fluid that contains a glycol compound (A), at least one substance (B) selected from the group consisting of organic amines and inorganic alkalis, a surfactant (C), and water (D), the water-soluble cutting or grinding fluid having a contact angle of 2 to 15° as measured using the ?/2 method one second after a drop of a dilution of the water-soluble cutting or grinding fluid is dropped on an SPCC-SB plate.Type: ApplicationFiled: May 28, 2014Publication date: April 21, 2016Applicant: NTN CORPORATIONInventors: Masashi KITAI, Kohei HIGASHI, Hidekazu HIRANO, Hajime ISA, Masanori NISHIRA, Hitoshi SHIOTANI, Keiji IWAMOTO, Youhei MIGAKI
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Patent number: 9267940Abstract: The present invention provides a disc-like assay chip, and more specifically, the present invention provides an assay chip which can effectively clean a cleaned object existing in a fluid loop, and can be appropriately applied to a detection method of a reaction system using a step of necessarily cleaning the cleaned object, such as an immunofluorescent antibody method, and applied to a detection method using an enzymatic reaction (especially, an ELISA method). The present invention further provides a disc-like assay chip which is mounted on a centrifugal device such as a rotational disc and can perform detection or quantitation on a target substance through optical measurement after a specimen and a reagent react by use of a centrifugal force generated by rotation of the centrifugal device.Type: GrantFiled: March 10, 2015Date of Patent: February 23, 2016Assignee: Rohm Co., Ltd.Inventors: Keiji Iwamoto, Kazuhiro Oguchi, Kenji Hamachi
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Publication number: 20160032056Abstract: The present invention relates to a polyimide precursor comprising a repeating unit represented by the following chemical formula (1): wherein A is a tetravalent group having at least one aliphatic six membered ring and no aromatic ring in the chemical structure, and B is a divalent group having at least one amide bond and an aromatic ring in the chemical structure; or A is an aliphatic tetravalent group and B is a divalent group having at least one chemical structure represented by the following chemical formula (2) in the chemical structure: and X1 and X2 are each independently hydrogen, a C1-6 alkyl group or a C3-9 alkylsilyl group.Type: ApplicationFiled: August 7, 2015Publication date: February 4, 2016Inventors: Ryoichi Takasawa, Takuya Oka, Yukinori Kohama, Miharu Nakagawa, Keiji Iwamoto, Kenji Hirotsu, Yoshiyuki Watanabe
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Publication number: 20150226730Abstract: The present invention provides a disc-like assay chip, and more specifically, the present invention provides an assay chip which can effectively clean a cleaned object existing in a fluid loop, and can be appropriately applied to a detection method of a reaction system using a step of necessarily cleaning the cleaned object, such as an immunofluorescent antibody method, and applied to a detection method using an enzymatic reaction (especially, an ELISA method). The present invention further provides a disc-like assay chip which is mounted on a centrifugal device such as a rotational disc and can perform detection or quantitation on a target substance through optical measurement after a specimen and a reagent react by use of a centrifugal force generated by rotation of the centrifugal device.Type: ApplicationFiled: March 10, 2015Publication date: August 13, 2015Inventors: Keiji Iwamoto, Kazuhiro Oguchi, Kenji Hamachi
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Patent number: 9005547Abstract: The present invention provides a disc-like assay chip, and more specifically, the present invention provides an assay chip which can effectively clean a cleaned object existing in a fluid loop, and can be appropriately applied to a detection method of a reaction system using a step of necessarily cleaning the cleaned object, such as an immunofluorescent antibody method, and applied to a detection method using an enzymatic reaction (especially, an ELISA method). The present invention further provides a disc-like assay chip which is mounted on a centrifugal device such as a rotational disc and can perform detection or quantitation on a target substance through optical measurement after a specimen and a reagent react by use of a centrifugal force generated by rotation of the centrifugal device.Type: GrantFiled: March 23, 2012Date of Patent: April 14, 2015Assignee: Rohm Co., Ltd.Inventors: Keiji Iwamoto, Kazuhiro Oguchi, Kenji Hamachi
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Patent number: 8900528Abstract: A disc-shaped analysis chip has an internal space. The internal space includes: a first reservoir for accommodating a first liquid; a second reservoir and a third reservoir arranged nearer to an outer peripheral portion of the analysis chip than the first reservoir; a fourth reservoir, a fifth reservoir and a sixth reservoir for accommodating a second liquid, a third liquid and a fourth liquid, respectively, and being arranged nearer to the outer peripheral portion of the analysis chip than the second and the third reservoir; a seventh reservoir arranged nearer to the outer peripheral portion of the analysis chip than the fourth to the sixth reservoir; an eighth reservoir arranged nearer to the outer peripheral portion of the analysis chip than the seventh reservoir; and a first to an eighth flow path for appropriately interconnecting the first to the eighth reservoir.Type: GrantFiled: July 27, 2012Date of Patent: December 2, 2014Assignee: Rohm Co., Ltd.Inventors: Kenji Hamachi, Keiji Iwamoto, Kazuhiro Oguchi
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Publication number: 20140066571Abstract: A polyimide precursor comprising a repeating unit represented by the following chemical formula (1): in which A is a tetravalent group having at least one aliphatic six-membered ring and no aromatic ring in the chemical structure, and B is a divalent group having at least one amide bond and an aromatic ring in the chemical structure; or A is an aliphatic tetravalent group and B is a divalent group having at least one chemical structure represented by the following chemical formula (2) in the chemical structure: and X1 and X2 are each independently hydrogen, a C1-6 alkyl group or a C3-9 alkylsilyl group.Type: ApplicationFiled: March 12, 2012Publication date: March 6, 2014Applicant: UBE INDUSTRIES, LTD.Inventors: Ryoichi Takasawa, Takuya Oka, Yukinori Kohama, Miharu Nakagawa, Keiji Iwamoto, Kenji Hirotsu, Yoshiyuki Watanabe
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Publication number: 20130029361Abstract: A disc-shaped analysis chip has an internal space. The internal space includes: a first reservoir for accommodating a first liquid; a second reservoir and a third reservoir arranged nearer to an outer peripheral portion of the analysis chip than the first reservoir; a fourth reservoir, a fifth reservoir and a sixth reservoir for accommodating a second liquid, a third liquid and a fourth liquid, respectively, and being arranged nearer to the outer peripheral portion of the analysis chip than the second and the third reservoir; a seventh reservoir arranged nearer to the outer peripheral portion of the analysis chip than the fourth to the sixth reservoir; an eighth reservoir arranged nearer to the outer peripheral portion of the analysis chip than the seventh reservoir; and a first to an eighth flow path for appropriately interconnecting the first to the eighth reservoir.Type: ApplicationFiled: July 27, 2012Publication date: January 31, 2013Applicant: ROHM CO., LTD.Inventors: Kenji HAMACHI, Keiji IWAMOTO, Kazuhiro OGUCHI
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Publication number: 20120244607Abstract: The present invention provides a disc-like assay chip, and more specifically, the present invention provides an assay chip which can effectively clean a cleaned object existing in a fluid loop, and can be appropriately applied to a detection method of a reaction system using a step of necessarily cleaning the cleaned object, such as an immunofluorescent antibody method, and applied to a detection method using an enzymatic reaction (especially, an ELISA method). The present invention further provides a disc-like assay chip which is mounted on a centrifugal device such as a rotational disc and can perform detection or quantitation on a target substance through optical measurement after a specimen and a reagent react by use of a centrifugal force generated by rotation of the centrifugal device.Type: ApplicationFiled: March 23, 2012Publication date: September 27, 2012Applicant: ROHM CO., LTD.Inventors: Keiji Iwamoto, Kazuhiro Oguchi, Kenji Hamachi
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Patent number: 7741497Abstract: The present invention is to provide a process for preparing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound represented by the formula (1): wherein R1 and R2 may be the same or different from each other, and represent a group which does not participate in the reaction, and R1 and R2 may be bonded to form a ring, and the ring may contain a hetero atom(s), and R3 represents a hydrocarbon group, which comprises reacting 4-acyltetrahydropyran represented by the formula (2): wherein R1 and R2 have the same meanings as defined above, and a carbonic acid diester represented by the formula (3): wherein R3 has the same meanings as defined above, and two R3s may be bonded to each other to form a ring, in the presence of a base, and a process for preparing 4-acyltetrahydropyran.Type: GrantFiled: December 17, 2004Date of Patent: June 22, 2010Assignee: Ube Industries, Ltd.Inventors: Shigeyoshi Nishino, Kenji Hirotsu, Hidetaka Shima, Keiji Iwamoto, Takashi Harada
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Publication number: 20080306287Abstract: The present invention is to provide a process for preparing tetrahydropyran-4-carboxylic acid represented by the formula (1): which comprises hydrolyzing a 4-cyanotetrahydropyran-4-carboxylic acid compound represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, in the presence of an acid; a process for preparing a tetrahydropyran-4-carboxylic acid ester which comprises reacting the tetrahydropyran-4-carboxylic acid represented by the above-mentioned formula (1) with an alcohol in the presence of an acid; and a process for preparing tetrahydropyran-4-carboxylic acid amide which comprises reacting the tetrahydropyran-4-carboxylic acid represented by the above-mentioned formula (1) with a halogenating agent to prepare tetrahydropyran-4-carboxylic acid halide, and then, reacting an amine compound to the resulting compound.Type: ApplicationFiled: November 18, 2005Publication date: December 11, 2008Applicant: UBE INDUSTRIES, LTD.Inventors: Shigeyoshi Nishino, Kenji Hirotsu, Hidetaka Shima, Takashi Harada, Taku Nakamura, Keiji Iwamoto
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Patent number: 7365215Abstract: The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (1): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (2): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, a noble metal catalyst and a metal oxide, and a synthetic intermediate thereof and a process for preparing the same.Type: GrantFiled: July 14, 2004Date of Patent: April 29, 2008Assignee: Ube Industries, Ltd.Inventors: Shigeyoshi Nishino, Kenji Hirotsu, Hidetaka Shima, Keiji Iwamoto, Takashi Harada, Shinobu Suzuki
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Patent number: 7300953Abstract: The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2): wherein R represents a cyano group, a carboxyl group or an ester group, R1 and R2 each represent a group which does not participate in the reaction, which may have a substituent, and R1 and R2 may be combined to each other to form a ring, which comprises subjecting an acetic acid compound represented by the formula (1): wherein R, R1 and R2 have the same meanings as defined above, to decarboxylation in the presence of a metal catalyst.Type: GrantFiled: September 17, 2004Date of Patent: November 27, 2007Assignee: Ube Industries, LtdInventors: Shigeyoshi Nishino, Kenji Hirotsu, Hidetaka Shima, Keiji Iwamoto, Takashi Harada