Abstract: The present invention provides a modified atrial natriuretic peptide that exhibits prolonged duration in blood and maintains cGMP elevating activity. The present invention provides a modified peptide in which at least one sugar substance is linked directly through a glycosidic bond or via a linker structure to at least one hANP peptide, or a pharmaceutically acceptable salt thereof, a medicament comprising the modified peptide or the salt thereof as an active ingredient, etc.

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: A: e.g., Benzene, E: e.g., —CH2—, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R1, R2, R3: e.g., a halogen atom, R4: e.g., a C1-C6 alkyl group, R5: e.g., a hydrogen atom, R6a, R6b, R6c, R6d: e.g., a hydrogen atom, R7: e.g., a hydrogen atom, R8: e.g., a hydrogen atom, n1, n2, n3: e.g., 1.

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

Abstract: The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem.

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

Abstract: An electronic-device-sealing resin composition and an organic EL element, having, as a crosslinkable organometallic desiccant, a metal complex compound having crosslinkable alkoxide represented by formula (1) as a ligand: M(ORx)n??Formula (1) wherein, in formula (1), M designates Al, B, Ti or Zr; Rx in the ligand designates an alkyl group, an alkenyl group, an aryl group, a cycloalkyl group, a heterocyclic group, an acyl group, or a group represented by formula (a); at least one of Rx's has a crosslinkable group; and n designates a valence of M. wherein, in formula (a), O* designates O of ORx in formula (1); R1 designates an alkyl group, an alkenyl group or an acyl group; R2 designates a hydrogen atom or an alkyl group; and R3 designates an alkyl group or an alkoxy group.

Abstract: A damper includes a cylinder that seals a magneto-rheological fluid, a piston slidably disposed in the cylinder, and a piston rod coupled to the piston. The piston includes a piston core, a flux ring, a plate, and a fixing nut. The piston core is mounted on the piston rod. The piston core has an outer periphery on which a coil is disposed. The flux ring forms a flow passage for the magneto-rheological fluid with the piston core. The plate is disposed on an outer periphery of the piston rod, has an outer peripheral surface housed in a one-end of the flux ring, and is bonded on the flux ring by brazing. The fixing nut sandwiches the plate with the piston core.

Abstract: Provided are a resin composition for element encapsulation for organic electronic devices which is transparent, has excellent flexibility, water vapor barrier properties, and adhesive force, and can suppress the generation of dark spots, a resin sheet for element encapsulation for organic electronic devices, an organic electroluminescent element, and an image display device. This adhesive resin composition for element encapsulation for organic electronic devices is used to seal an element for organic electronic devices, and is characterized by containing a diene polymer and a softening agent, in which the content of the softening agent is from 5% by mass to 30% by mass of the total mass.

Abstract: An electronic-device-sealing resin composition and an organic EL element, having, as a crosslinkable organometallic desiccant, a metal complex compound having crosslinkable alkoxide represented by formula (1) as a ligand: M(ORx)n??Formula (1) wherein, in formula (1), M designates Al, B, Ti or Zr; Rx in the ligand designates an alkyl group, an alkenyl group, an aryl group, a cycloalkyl group, a heterocyclic group, an acyl group, or a group represented by formula (a); at least one of Rx's has a crosslinkable group; and n designates a valence of M. wherein, in formula (a), O* designates O of ORx in formula (1); R1 designates an alkyl group, an alkenyl group or an acyl group; R2 designates a hydrogen atom or an alkyl group; and R3 designates an alkyl group or an alkoxy group.

Abstract: A piston of a magnetorheological fluid shock absorber is provided with a piston core having a small diameter portion mounted on an end portion of the piston rod, an enlarged diameter portion formed continuously in an axial direction with a diameter larger than the small diameter portion and forming a stepped portion, and a large diameter portion formed continuously in the axial direction with a diameter larger than the enlarged diameter portion and having a coil; a ring body surrounding the outer periphery of the piston core and forming a flow passage of the magnetorheological fluid between itself and the large diameter portion; a plate formed annularly and arranged on the outer periphery of the small diameter portion and mounted on one end of the ring body; and a stopper mounted on the small diameter portion and sandwiching the plate between the stopper and the stepped portion.

Abstract: A suspension device interposed between a vehicle body and a wheel, including a magnetic viscous fluid shock absorber in which a magnetic viscous fluid is sealed, a tube member composed of an outer tube connected to the vehicle body side and an inner tube connected to the wheel side and going into/out of the outer tube and accommodating the magnetic viscous fluid shock absorber, a lubricant liquid stored in the tube member, and a seal member closing a space between the inner tube and the magnetic viscous fluid shock absorber and preventing intrusion of the lubricant liquid to the wheel side.

Abstract: A transparent resin composition for sealing an organic EL element and other things having a sufficient effect of blocking moisture and excellent flexibility is provided. As essential components, a thermoplastic resin, tackifying resin and organometallic compound represented by the following chemical formula are included, having a light transmittance of 85% or more, and having a relationship of AM/Y<162, A: the acid value excluding the organometallic compound M: the weight average molecular weight of the organometallic compound Y: the weight ratio of the organometallic compound with respect to 100 parts by weight of resin components wherein the thermoplastic resin contains a hydride of a styrene-based A-B-A type triblock, wherein R1 to R4 represent organic groups including an alkyl group, aryl group, alkoxy group, cycloalkyl group and acyl group, each having a carbon number of 1 or more and 8 or less, M represents a metal atom having 3 valency.

Abstract: The entire length of a piston (20) of a magnetorheological fluid shock absorber (100) is reduced. The piston (20) includes a piston core (30) mounted on an end portion of a piston rod (21) and having a coil (33) provided on an outer periphery, a flux ring (35) surrounding the outer periphery of the piston core (30) and forming a flow passage for a magnetorheological fluid, a plate (40) formed annularly, arranged on an outer periphery of the piston rod, and joined to one end of the flux ring (35) through brazing, and a stopper containing a fixing nut (50). The flux ring (35) and the plate (40) are joined by a metal layer.

Abstract: A front fork includes a pair of dampers standing on both sides of a wheel. One of the pair of dampers is a magnetic viscous fluid damper configured to use a magnetic viscous fluid whose viscosity is changed by an action of a magnetic field as a working fluid, while the other of the pair of dampers is a liquid-pressure damper configured to use a liquid such as oil, water, an aqueous solution and the like as the working fluid.

Abstract: A piston of a magnetic rheological fluid shock absorber comprises a piston core that is formed from a magnetic material and is provided with a coil on the outer periphery thereof, and a ring body that is formed from a magnetic material, surrounds the outer periphery of the piston core. A flow path of the magnetic rheological fluid is formed between the ring body and the piston core. The flow path of the magnetic rheological fluid comprises a first flow path part having a predetermined cross-sectional flow area, and a second flow path part having a larger cross-sectional flow area than the predetermined cross-sectional flow area and a longer axial length than the coil to cover the outer periphery of the coil.

Abstract: A shock absorber mounting device joins a shock absorber provided between an axle and a vehicle body to the vehicle body. The shock absorber mounting device includes a magnetic rubber mount having magnetic particles thereinside and being provided between the shock absorber and the vehicle body, an electromagnetic coil configured to apply a magnetic field to the magnetic particles, and a controller configured to supply an excitation current to the electromagnetic coil.

Abstract: A piston of a magnetorheological fluid shock absorber is provided with a piston core having a small diameter portion mounted on an end portion of the piston rod, an enlarged diameter portion formed continuously in an axial direction with a diameter larger than the small diameter portion and forming a stepped portion, and a large diameter portion formed continuously in the axial direction with a diameter larger than the enlarged diameter portion and having a coil; a ring body surrounding the outer periphery of the piston core and forming a flow passage of the magnetorheological fluid between itself and the large diameter portion; a plate formed annularly and arranged on the outer periphery of the small diameter portion and mounted on one end of the ring body; and a stopper mounted on the small diameter portion and sandwiching the plate between the stopper and the stepped portion.