Abstract: A platform may receive configuration information of individual user authorizations for outbound messaging through specification of one or more authorized vendors. The platform maintains a list of the vendors and, for each vendor, a DKIM public key associated with the vendor, without publishing the public keys to a DNS, and publishes a customized SPF policy comprising a macro mechanism for identifying a particular user that transmitted a message to the DNS. The platform logs received SPF customized queries, extracts data populated by the macro mechanism from the logged queries, and analyzes the extracted data to determine a particular user associated with the query, to determine whether the user is authorized to utilize a vendor associated with the domain based on the configuration information. Responsive to the determination that the individual is authorized to utilize the vendor, the platform publishes the DKIM public key associated with the vendor to the DNS.

Abstract: Sender Policy Framework (SPF) is one of the most widely used methods of distinguishing electronic mail that is authorized by the purported sending domain from unauthorized mail. SPF policies are published into a domain's DNS and then looked up and evaluated by mail receivers. Due to the complexity and limitations of the SPF specification, implementation mistakes are widespread. This problem is compounded by the common practice of nesting SPF policies which introduces hidden risks, particularly exceeding DNS lookup limits. To address these issues, inline service provider designation may be configured to capture the benefits of existing techniques without their associated costs. Additionally, the domain owner may enjoy simplified SPF service provider onboarding and policy failover redundancy to protect against SPF service provider disruptions, thus improving policy availability uptime.

Abstract: A sliding subsea foundation comprises a polymeric shoe layer on the underside of a mudmat or subsea structure. The shoe layer defines a soil-engaging face that comprises an array of parallel grooves. The grooves are shallower than the thickness of the shoe layer such that each groove has a closed top, defined by and integral with the shoe layer, that spans the groove. Where a subsea structure is supported on the foundation with a subsea pipeline attached to the structure, the grooves are substantially parallel to a longitudinal axis of the pipeline.

Abstract: The present invention relates to a tank piston with an improved seal having a cap, a body attached to the periphery of the cap, a circumferential channel adjacent to the periphery of the cap and an annular seal held within the channel by an annular sheet. In one aspect of the invention the annular sheet secures the seal within the channel and is attached to the piston by a ring proximate to the periphery of the cap and a ring proximate to the back side of the circumferential channel. In another aspect of the invention the annular sheet is made from a friction reducing material and enables the piston to more easily move within the tank and subsequently extends the lifespan of the seal. Additionally, the annular sheet is fitted to the seal and attached above the front sidewall of the channel.

Abstract: A method of treating an ocular surface disorder in a subject in need of such treatment is provided. The method includes exposing conjunctival tissue of the subject to an effective amount of a vasopermeability agent that increases conjunctival vascular permeability. In some embodiments, the agent is a nitric oxide donor, which may be in a sustained release form. A method of screening a substance for treating an ocular surface disorder is also provided.

Abstract: The present invention addresses the treatment of age-related macular degeneration using regulation of pathogenic mechanisms similar to atherosclerosis. In further specific embodiments, compositions that increase reverse cholesterol transport are utilized as therapeutic targets for age-related macular degeneration. In a specific embodiment, the lipid content of the retinal pigment epithelium, and/or Bruch's membrane is reduced by delivering Apolipoprotein A1, particularly a mimetic peptide.

Abstract: The present invention addresses the treatment of age-related macular degeneration using regulation of pathogenic mechanisms similar to atherosclerosis. In further specific embodiments, reverse cholesterol transport components, such as transporters and HDL fractions, are utilized as diagnostic and therapeutic targets for age-related macular degeneration. In a specific embodiment, the lipid content of the retinal pigment epithelium, and/or Bruch's membrane is reduced.