Abstract: An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and radially movable relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are engaged with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.

Abstract: A method of manufacturing a plate suitable for use as a bipolar plate 500 in a bipolar battery 1 is disclosed. The method comprises the steps of extruding a first polymer containing conductive particles to form a conductive polymer plate 505, cutting a conductive polymer core 512 from the conductive polymer plate 505, and overmoulding the conductive polymer core 512 with a second polymer to provide a non-conductive polymer surround 516. A bipolar battery 1 is also disclosed, as well as a method of making a bipolar battery 1.

Abstract: The present invention relates to the method of treating heavy menstrual bleeding in a subject with or without uterine fibroids and in need of treatment by administering an effective amount of 4-((R)-2-[5-(2-fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethylamino)-butyric acid or a pharmaceutically acceptable salt thereof, in combination with estrogens and progestogens.

Abstract: The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using such compositions. The disclosure also relates to methods of facilitating release of a GnRH antagonist from a pharmaceutical composition.

Abstract: A bipolar battery (1) comprising a stack of multiple bipolar plates (9) sandwiched between two monopolar plates (6, 8) is disclosed. The bipolar plates (9) each comprise a conductive polymer core (22) and an integrally formed non-conductive polymer surround (4), a layer of cathode material (16) on a first side of the bipolar plate (9), and a layer of anode material (28) on a second, opposite side of the bipolar plate (9). The integrally formed non-conductive polymer surround (4) extends from the conductive polymer core (22) further on one side than the other, such that on one side a first recess (19) is defined for accommodating electrolyte material of the battery (1). The layers of anode material (28) and cathode material (16) are contained within a casing formed at least in part by the integrally formed non-conductive polymer surrounds (4) of all of the bipolar plates (9).

Abstract: The present invention relates to the method of treating heavy menstrual bleeding in a subject with or without uterine fibroids and in need of treatment by administering an effective amount of 4-((R)-2-[5-(2-fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethylamino)-butyric acid or a pharmaceutically acceptable salt thereof, in combination with estrogens and progestogens.

Abstract: A hairnet is formed of a knitted fabric with parallel lines of stitches connected by transverse threads. The density of threads in the parallel lines of stitches is greater than the density of the transverse threads.

Abstract: The invention relates to a surgical shield, wherein the shield includes one or more walls including at least one substantially smooth surface, the one or more walls individually or collectively forming a single substantially elongate member; and at least one attachment means directly or indirectly attached to the one or more walls for securing the shield in position during a surgery.

Abstract: The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using such compositions. The disclosure also relates to methods of facilitating release of a GnRH antagonist from a pharmaceutical composition.

Abstract: The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using such compositions. The disclosure also relates to methods of facilitating release of a GnRH antagonist from a pharmaceutical composition.

Abstract: The invention relates to a surgical shield, wherein the shield includes one or more walls including at least one substantially smooth surface, the one or more walls individually or collectively forming a single substantially elongate member; and at least one attachment means directly or indirectly attached to the one or more walls for securing the shield in position during a surgery.

Abstract: Provided is a hat formed from a single piece of fabric. The single piece of fabric comprises parallel regions of fabric including first and second headband regions and at least one intermediate region. The headband regions are joined at their ends to form a headband and the intermediate region forms the crown of the hat. The headband regions and the at least one intermediate region are of differing stiffness and/or thickness.

Abstract: A post-operative assistive sitting device configured to prevent pressure being applied to a post-operative patient's recovery area thereby allowing a patient to sit and conduct normal daily activities after a medical procedure. The post-operative assistive sitting device includes a chair that defines an opening and a series of cushions and paddings surrounding the opening to alleviate the pressure and discomfort from the recovery area without disturbing the buttocks as the patient sits or lies in a natural position.

Abstract: A method and kit are provided for identifying non-healing or healing chronic mammalian wound tissue or for determining the prognosis of chronic mammalian wound tissue based upon the identification of at least one key set of molecular markers or genes whose expression pattern is indicative of a given wound type and so representative of a given prognosis.

Abstract: The invention relates to a method and kit for identifying chronic or acute mammalian wound tissue or for determining the prognosis of mammalian wound tissue based upon the identification of at least one key set of molecular markers or genes whose expression pattern is indicative of a given wound type and so representative of a given prognosis.

Abstract: A hair retention bonnet comprises a unitary piece of knitted fabric, the bonnet having elasticated edges and at least one cinch point and being adapted to conform closely to a wearer's head, wherein the knitted fabric comprises both non-textured and textured yarns. Hair retention articles are selected from a beard cover, a neck shield, an arm cover and a hair retention cap. There is also provided a plurality of connected bonnets. The bonnets may stretch to an appropriate size and shape to snugly fit the user's head, enabling a single size of bonnet to be worn by all users, allowing a uniform expansion or contraction of the bonnet, having a relatively large surface contact area to the user's hair regardless of head size or hairstyle and effectively gripping and holding any protruding hairs to prevent shedding.

Abstract: A hairnet is formed of a knitted fabric with parallel lines of stitches connected by transverse threads. The density of threads in the parallel lines of stitches is greater than the density of the transverse threads.

Abstract: A system maintains online functionality during an outage. The system includes a processing device configured for receiving a request for online interaction via a network from a client system and identifying a primary interaction system configured to respond to the request. The processing device is also configured for determining the primary interaction system is incapable of providing the online interaction associated with the request, identifying an alternative interaction system configured to respond to the request, and initiating an online interaction between the client system and the alternative interactive system. In some embodiments, the primary interaction system is incapable of providing website content, and the processing device initiates an exchange of alternative website content.