Abstract: A meter for measuring the flow rate of fuel in a fuel dispenser comprises a housing with an axial bore extending therethrough and defining an inlet and an outlet. A flow indicating mechanism comprising one or more rotatable components are mounted in the axial bore of the housing and configured to rotate as fuel flows from the inlet to the outlet, wherein each rotation indicates fuel flow. A pulse generating device senses rotation of the rotatable components and generates an output signal indicative of the fuel flow. Finally, a vapor generating device is configured to generate vapor bubbles that flow through the flow indicating mechanism.

Abstract: A drum tuning key includes a body having a longitudinal axis, a first end and a second end, the first end including a keyed interface configured to releaseably engage an element of a tuning assembly of a drum for cooperative rotation therewith and the second end including a radially-extending portion configured to be manipulated by a user to apply a torque in relation to the longitudinal axis to operate the tuning assembly, and a magnet carried by the body and having a first end, a second end, and an axis of magnetization extending between the first end and the second end, wherein at least one of the first end or the second end of the magnet is located at or adjacent an outer surface of the body.

Abstract: Systems and methods for automated aggregated content commenting are disclosed herein. Such a system can include a memory including a content database; an evaluation criteria database; and a comment database. The system can include at least one server. The at least one server can: receive a content identifier; receive a user identifier; provide a representation of the piece of content to the user; receive a comment from the user identifying a portion of the piece of content; generate a portion of the comment database linked to the user and the content; generate an entry in the portion of the comment database linked to the user and the content; and store the comment in the entry in the portion of the comment database.

Abstract: Techniques are disclosed for forming a package substrate with integrated stiffener. A panel of package substrates are provided. An adhesion layer is then formed on each package substrate of the panel of package substrates. A panel of stiffeners are then attached to the panel of package substrates by the adhesion layer, each stiffener corresponding to a respective package substrate. The panel of package substrates is then singulated into individual package substrates with integrated stiffeners. The stiffeners on the singulated package substrates include tabs that extend to the edges of the package substrates.

Abstract: The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Abstract: The invention provides inhibitors of hypoxia-inducible factors (HIF), and their use in the prevention or inhibition of diseases characterised by abnormal HIF activity or levels, such as tumour progression, and the treatment of cancer. The invention encompasses pharmaceutical compositions with a mechanism of action for blocking elevated HIF activity in diseases, such as cancer.

Abstract: The invention relates to a method of coating an aged coating layer on a substrate and a coating composition which can be used in this method. The coating composition, is typically a fouling release coating composition, and comprises a curable or crosslinkable organosiloxane polymer, an organobismuth compound and a silane coupling agent.

Abstract: The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts, hydrates and solvates thereof for use in the treatment of cancer:

Abstract: The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Abstract: A meter for measuring the flow rate of fuel in a fuel dispenser comprises a housing with an axial bore extending therethrough and defining an inlet and an outlet. A flow indicating mechanism comprising one or more rotatable components are mounted in the axial bore of the housing and configured to rotate as fuel flows from the inlet to the outlet, wherein each rotation indicates fuel flow. A pulse generating device senses rotation of the rotatable components and generates an output signal indicative of the fuel flow. Finally, a vapor generating device is configured to generate vapor bubbles that flow through the flow indicating mechanism.

Abstract: A first state of an interconnect protocol is entered. A particular signal is sent according to the protocol to a device over a link. During the first state, it is detected that a response to the particular signal is received in the first state. It is determined that the device supports a configuration mode outside the protocol based on the received response. The configuration mode is entered based on the response. One or more in-band configuration messages are sent within the configuration mode.

Abstract: Techniques are disclosed for forming a package substrate with integrated stiffener. A panel of package substrates are provided. An adhesion layer is then formed on each package substrate of the panel of package substrates. A panel of stiffeners are then attached to the panel of package substrates by the adhesion layer, each stiffener corresponding to a respective package substrate. The panel of package substrates is then singulated into individual package substrates with integrated stiffeners. The stiffeners on the singulated package substrates include tabs that extend to the edges of the package substrates.

Abstract: An adaptor for coupling to a drum having a drum head, shell, and rim, the rim having an outer diameter and configured to interface with a ring coupled to the drum head to hold the drum head in place on the shell, includes a monolithic body having a clip portion and an interface, the clip portion configured to extend around an outer section of the rim between a top surface of the drum head and a bottom portion of the rim, the clip portion having a clip end and the ring having an outer diameter, wherein the clip end is configured to extend to a position that is inward of the outer diameter of the ring when the clip portion is coupled to the drum; and wherein a substantial portion of the interface is configured to extend radially from the rim when the clip portion is coupled to the drum.

Abstract: Described herein are inventions directed to methods of treating a diastolic cardiac dysfunction and the symptoms thereof in a subject that includes administering an amount of a TRPV2 receptor agonist effective to treat the diastolic cardiac dysfunction. The TRPV2 receptor agonist may be administered in at least one of an injection, orally, or transdermally. The amount of TRPV2 receptor agonist is sufficient to result in an improved performance on quantitative diagnostic criteria. In an embodiment, the TRPV2 receptor agonist is administered over a period of about 8 hours to about 24 hours. The TRPV2 receptor agonist may be used for short term treatments, i.e., less than a week, or it may be administered in a long term manner, i.e., over a period of weeks, months, or even years. Exemplary TRPV2 receptor agonists include probenecid, 2-aminoethoxydiphenyl borate, cannabinol, cannabidiol, and combinations thereof.

Abstract: Acoustic transducers may, in certain aspects, include a curved diaphragm and an actuator coupled to the curved diaphragm to cause movement of the curved diaphragm. In certain embodiments, the curved diaphragm has at least one free edge. The left and right edges of the curved diaphragm may be associated with auxiliary supports. The acoustic transducer can be a multi-pole loudspeaker wherein a curved diaphragm radiates the sound energy in a modified dipole pattern. The curvature of the radiating surface of the transducer reduces sound cancellation from sound energy reflected by nearby surfaces.

Abstract: Methods of inhibiting ischemia-related and ischemia-reperfusion-related injury are provided. Remote administration of a C-fiber activator or TRPV1 agonist or remote electrical stimulation and activation of TRPV1 reduces ischemia-related tissue damage in subjects at risk for ischemia-related tissue damage. In aspects of the invention, remote application of a TRPV1 agonist inhibits ischemia-related cardiac tissue damage. Methods of inhibiting cardiac tissue damage by topically administering the TRPV1 agonist, capsaicin are provided.

Abstract: Fire hydrants each have a band of lamps strapped around them, the lamps powered by a solar collector battery circuit. An RF signal is transmitted to a receiver in the circuit by a remote responder causing the lamps to light up with a coded color related to the water flow rating of each of the hydrants and with a blink rate related to the water pressure of each of the hydrants. Upon arriving at the fire scene responders are able to select an appropriate hydrant for the location and size of the fire. The circuit is able to transmit flow and pressure information to the responders which information is presented on a display screen for early reconnaissance of the water resources at the fire scene.