Patents by Inventor Keith Lowe
Keith Lowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9926571Abstract: A variety of methods and compostions are provided, including methods and compositions for targeted modification of a specific target site in a cell or organism, methods for integrating polynucleotides of interest, methods to assess promoter activity, directly select transformed organisms, minimize or eliminate expression resulting from random integration into the genome of an organism, such as a plant, remove polynucleotides of interest, combine multiple transfer cassettes, invert or excize a polynucleotide, silence a gene, and identify and/or characterize transcriptional regulating regions. The methods involve the introduction of a cell proliferation factor and a double-strand break-inducing enzyme into an organism.Type: GrantFiled: March 17, 2014Date of Patent: March 27, 2018Assignee: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: William Gordon-Kamm, Keith Lowe, David J Peterson, Christopher Scelonge, Grace M St Clair, Bing-Bing Wang
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Patent number: 9803215Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: GrantFiled: November 17, 2014Date of Patent: October 31, 2017Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANYInventors: Marc Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe
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Patent number: 9574208Abstract: Methods of making a targeted modification in a male fertility gene in the genome of a plant are disclosed. The methods involve contacting a plant cell with an engineered double-strand-break-inducing agent capable of inducing a double-strand break in a target sequence in the male fertility gene and identifying a cell comprising an alteration in the target sequence. Also disclosed are plants, plant cells, plant parts, and seeds comprising a male fertility gene with an alteration in a male fertility gene. Nucleic acid molecules comprising male fertility genes with at least one targeted modification therein, optimized nucleic acid molecules encoding endonucleases that are engineered double-strand-break-inducing agents and expression cassettes, host cells, and plants comprising one or more of the nucleic acid molecules are further disclosed.Type: GrantFiled: June 19, 2012Date of Patent: February 21, 2017Assignees: EI DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL INCInventors: Dennis L. Bidney, Mark Cigan, Carl Falco, Huirong Gao, Derek Jantz, Mike Lassner, Keith Lowe, Leszek Aleksander Lyznik, James Jefferson Smith
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Patent number: 9499837Abstract: Methods of making a targeted modification in a male fertility gene in the genome of a plant are disclosed. The methods involve contacting a plant cell with an engineered double-strand-break-inducing agent capable of inducing a double-strand break in a target sequence in the male fertility gene and identifying a cell comprising an alteration in the target sequence. Also disclosed are plants, plant cells, plant parts, and seeds comprising a male fertility gene with an alteration in a male fertility gene. Nucleic acid molecules comprising male fertility genes with at least one targeted modification therein, optimized nucleic acid molecules encoding endonucleases that are engineered double-strand-break-inducing agents and expression cassettes, host cells, and plants comprising one or more of the nucleic acid molecules are further disclosed.Type: GrantFiled: June 19, 2012Date of Patent: November 22, 2016Assignees: E.I. du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.Inventors: Dennis Bidney, Andrew Mark Cigan, Saverio Carl Falco, Huirong Gao, Derek Jantz, Mike Lassner, Keith Lowe, Leszek A Lyznik, James Jefferson Smith
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Publication number: 20160264993Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: ApplicationFiled: November 17, 2014Publication date: September 15, 2016Inventors: Marc Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe
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Publication number: 20150184194Abstract: Methods of making a targeted modification in a male fertility gene in the genome of a plant are disclosed. The methods involve contacting a plant cell with an engineered double-strand-break-inducing agent capable of inducing a double-strand break in a target sequence in the male fertility gene and identifying a cell comprising an alteration in the target sequence. Also disclosed are plants, plant cells, plant parts, and seeds comprising a male fertility gene with an alteration in a male fertility gene. Nucleic acid molecules comprising male fertility genes with at least one targeted modification therein, optimized nucleic acid molecules encoding endonucleases that are engineered double-strand-break-inducing agents and expression cassettes, host cells, and plants comprising one or more of the nucleic acid molecules are further disclosed.Type: ApplicationFiled: June 19, 2012Publication date: July 2, 2015Applicants: E.I. DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Dennis L. Bidney, Mark Cigan, Carl Falco, Huirong Gao, Derek Jantz, Mike Lassner, Keith Lowe, Leszek Aleksander Lyznik, James Jefferson Smith
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Patent number: 8927805Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: GrantFiled: February 22, 2011Date of Patent: January 6, 2015Assignees: Pioneer Hi Bred International Inc, E I du Pont de Nemours and CompanyInventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe
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Publication number: 20140243203Abstract: Compositions and methods relating to the use of sulfonylurea-mediated control of gene expression are provided. Compositions include sulfonylurea responsive chemical switches wherein the gene expression is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to regulate expression of a polynucleotide of interest in a cell or organism, and methods to modify a genome, including in a plant or plant cell.Type: ApplicationFiled: February 27, 2014Publication date: August 28, 2014Applicants: PIONEER HI-BRED INTERNATIONAL INC, E I DU PONT DE NEMOURS AND COMPANYInventors: JIN FANG, William Gordon-Kamm, Keith Lowe, Kevin E. McBride, Brian McGonigle, Carl Simmons
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Publication number: 20140237681Abstract: A variety of methods and compostions are provided, including methods and compositions for targeted modification of a specific target site in a cell or organism, methods for integrating polynucleotides of interest, methods to assess promoter activity, directly select transformed organisms, minimize or eliminate expression resulting from random integration into the genome of an organism, such as a plant, remove polynucleotides of interest, combine multiple transfer cassettes, invert or excise a polynucleotide, silence a gene, and identify and/or characterize transcriptional regulating regions. The methods involve the introduction of a cell proliferation factor and a double-strand break-inducing enzyme into an organism.Type: ApplicationFiled: March 17, 2014Publication date: August 21, 2014Applicant: PIONEER HI BRED INTERNATIONAL INCInventors: William Gordon-Kamm, Keith Lowe, David J. Peterson, Christopher Scelonge, Grace M. St Clair, Bing-Bing Wang
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Patent number: 8648228Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: GrantFiled: February 7, 2011Date of Patent: February 11, 2014Assignees: Pioneer Hi Bred International Inc, E I du Pont de Nemours and CompanyInventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe, Bailin Li, Marianna Faller
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Publication number: 20140020131Abstract: Methods of making a targeted modification in a male fertility gene in the genome of a plant are disclosed. The methods involve contacting a plant cell with an engineered double-strand-break-inducing agent capable of inducing a double-strand break in a target sequence in the male fertility gene and identifying a cell comprising an alteration in the target sequence. Also disclosed are plants, plant cells, plant parts, and seeds comprising a male fertility gene with an alteration in a male fertility gene. Nucleic acid molecules comprising male fertility genes with at least one targeted modification therein, optimized nucleic acid molecules encoding endonucleases that are engineered double-strand-break-inducing agents and expression cassettes, host cells, and plants comprising one or more of the nucleic acid molecules are further disclosed.Type: ApplicationFiled: June 19, 2012Publication date: January 16, 2014Applicants: E.I. du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.Inventors: Dennis L. Bidney, Andrew Mark Cigan, Saverio Carl Falco, Huirong Gao, Derek Jantz, Mike Lassner, Keith Lowe, Leszek Aleksander Lyznik, James Jefferson Smith
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Publication number: 20130145492Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: ApplicationFiled: February 22, 2011Publication date: June 6, 2013Applicants: E.I. DUPONT DE NEMOURS & COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe, Bailin Li, Marianna Faller
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Publication number: 20110191878Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: ApplicationFiled: February 7, 2011Publication date: August 4, 2011Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E.I. DUPONT DE NEMOURS & COMPANYInventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe, Bailin Li, Marianna Faller
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Publication number: 20110173714Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: ApplicationFiled: February 23, 2011Publication date: July 14, 2011Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E.I. DUPONT DE NEMOURS & COMPANYInventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe, Bailin Li, Marianna Faller
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Patent number: 7919676Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: GrantFiled: August 3, 2007Date of Patent: April 5, 2011Assignees: Pioneer Hi-Bred International, Inc., E. I. du Pont de Nemours & CompanyInventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe, Bailin Li, Marianna Faller
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Patent number: 7915478Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: GrantFiled: August 3, 2007Date of Patent: March 29, 2011Assignees: Pioneer Hi-Bred International, Inc., E.I. Du Pont de Nemours and CompanyInventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe, Bailin Li, Marianna Faller
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Patent number: 7910802Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: GrantFiled: August 3, 2007Date of Patent: March 22, 2011Assignees: Pioneer Hi-Bred International, Inc., E.I. Du Pont de Nemours & CompanyInventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe, Bailin Li, Marianna Faller
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Publication number: 20090038028Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: ApplicationFiled: August 3, 2007Publication date: February 5, 2009Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E.I. DUPONT DE NEMOURS & COMPANYInventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe, Bailin Li, Marianna Faller
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Publication number: 20090038026Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: ApplicationFiled: August 3, 2007Publication date: February 5, 2009Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E.I. DUPONT DE NEMOURS & COMPANYInventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe, Bailin Li, Marianna Faller
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Publication number: 20090038027Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.Type: ApplicationFiled: August 3, 2007Publication date: February 5, 2009Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E.I. DUPONT DE NEMOURS & COMPANYInventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe, Bailin Li, Marianna Faller