Abstract: The invention provides genetic constructs and recombinant vectors comprising such constructs. The constructs and vectors can be used in gene therapy methods for treating a range of disorders, including glaucoma and deafness, or for promoting nerve regeneration and/or survival.

Abstract: An automatic transmission multi-mode clutch module (10, 100) may include either two concentric (30B, 30A) or two axially (130B, 130A) spaced sets of pawls (30B, 130B, 30A, 130A) nested between a pair of inner (20, 120) and outer races (12, 112). A first set of pawls (30B, 130B) is secured to the outer race (12, 112), and may be selectively released from a normally spring-biased default engagement with the inner race (20, 120) by an actuator cam ring (16, 116) rotatable between two angular limits. A second set of pawls (30A, 130A) is secured to the inner race (20, 120), and is released from a normally spring-biased default engagement with the outer race (12, 112) whenever the inner race (20, 120) reaches a threshold rotational speed, at which centrifugal forces acting on the inner set of pawls (30A, 130A) overcome the default spring bias to disengage the pawls (30A, 130A) from the outer race (12, 112).

Abstract: A clutch for selectively preventing rotation of a rotating component may include a first and second pawls pivotable between engagement and disengagement with the rotating component to selectively prevent or allow rotation of the rotating component in one or both directions. An armature moveable between a first and second armature positions may have a common member pivotally connected thereto and engaging the first and second pawls, with a torque spring biasing the common member to rotate toward the first pawl and away from the second pawl. In an intermediate armature position, the common member may disengage the first pawl from the rotating component while engaging the second pawl to allow rotation in one direction while preventing rotation in the opposite direction. In embodiments, a clutch may include a cam actuator rotating to selectively control engagement of the pawls with the rotating component and locking in one or both directions.

Abstract: A flame resistant textile fabric includes a coating having an expandable graphite, or a combination of an expandable graphite and a nanoclay, disposed on one or both of its first and second surfaces. The flame resistant textile fabrics may be used to make one or more components of a mattress, such as a filler cloth, or fabric fire barrier.

Abstract: The present invention provides a composition which comprises the following Thyroid Stimulating Hormone Recept or (TSHR) peptides: (i) all or part of the amino acid sequence KKKKYVSIDVTLQQLESHKKK (SEQ ID NO: 1), or a part thereof, or a sequence having at least 60% sequence identity to SEQ ID NO:1; and (ii) all or part of the amino acid sequence GLKMFPDLTKVYSTD (SEQ ID NO: 2), or a part thereof, or a sequence having at least 60% sequence identity to SEQ ID NO:2. The present invention also relates to the use of such a composition for the prevention or suppression of activating autoantibody formation in Graves' disease.

Abstract: Various embodiments describe systems and processes for capturing and generating multi-view interactive digital media representations (MIDMRs). In one aspect, a method for automatically generating a MIDMR comprises obtaining a first MIDMR and a second MIDMR. The first MIDMR includes a convex or concave motion capture using a recording device and is a general object MIDMR. The second MIDMR is a specific feature MIDMR. The first and second MIDMRs may be obtained using different capture motions. A third MIDMR is generated from the first and second MIDMRs, and is a combined embedded MIDMR. The combined embedded MIDMR may comprise the second MIDMR being embedded in the first MIDMR, forming an embedded second MIDMR. The third MIDMR may include a general view in which the first MIDMR is displayed for interactive viewing by a user on a user device. The embedded second MIDMR may not be viewable in the general view.

Abstract: A multi-mode clutch module includes first and second races, and a plurality of race engagement mechanisms situated between the races. The module incorporates an actuator sleeve having an axially acting actuator cam finger. The cam finger is configured with variable radial thicknesses to provide a plurality of predetermined fixed positions for contacting the race engagement mechanisms to cause the engagement mechanisms to selectively interact with the races. The actuator sleeve is thus adapted to control axial movement of the actuator cam finger between at least two axially spaced positions in one embodiment. In other embodiments within the scope of this disclosure, the actuator cam finger may be adapted to move axially among any number of predetermined positions to operatively permit or prevent transmittal of torque between the first and second races, irrespective of the relative rotational direction of the races.

Abstract: Submerged combustion glass manufacturing systems include a melter having a floor, a roof, a wall structure connecting the floor and roof, and an exhaust passage through the roof. One or more submerged combustion burners are mounted in the floor and/or wall structure discharging combustion products under a level of material being melted in the melter and create turbulent conditions in the material. The melter exhausts through an exhaust structure connecting the exhaust passage with an exhaust stack. The exhaust structure includes a barrier defining an exhaust chamber having an interior surface, the exhaust chamber having a cross-sectional area greater than that of the exhaust stack but less than the melter. The barrier maintains temperature and pressure in the exhaust structure at values sufficient to substantially prevent condensation of exhaust material on the interior surface.

Abstract: An actuator device (22) for a multi-mode clutch module (8) may be configured to interact with a bellcrank (40) to selectively control movements of a plurality of pawls (18) situated between a driving member (16) and a driven member (12) of the multi-mode clutch module (8). The bellcrank (40) may pivot about a pivot point (42) of the driven member (12). The actuator device (22) may engage the bellcrank (40) for moving the actuator ring (20) between a plurality of angular positions and selectively control the plurality of pawls (18) to allow multiple modes of engagement such that the driving member (16) and the driven member (12) are configured to allow multiple modes of operation of the multi-mode clutch module (8).

Abstract: An alert source issues security alerts to an identity provider, which acts as a gatekeeper to a secure resource. Each security alert is associated with an alert user identity and a security threat. When a user identity requests access to the secure resource, the identity provider may look up security alerts associated with the user identity, such as by matching up the user identity with the alert user identity associated with each alert. Based on any discovered security alerts that correspond to the user identity and a pre-defined security policy, the identity provider may perform various security actions on the user identity. The identity provider may provide access to the secure resource without containing the user identity if there are no discovered security alerts associated with the user identity, or if the discovered security alerts pose a minor threat.

Abstract: Submerged combustion glass manufacturing systems include a melter having a floor, a roof, a wall structure connecting the floor and roof, and an exhaust passage through the roof. One or more submerged combustion burners are mounted in the floor and/or wall structure discharging combustion products under a level of material being melted in the melter and create turbulent conditions in the material. The melter exhausts through an exhaust structure connecting the exhaust passage with an exhaust stack. The exhaust structure includes a barrier defining an exhaust chamber having an interior surface, the exhaust chamber having a cross-sectional area greater than that of the exhaust stack but less than the melter. The barrier maintains temperature and pressure in the exhaust structure at values sufficient to substantially prevent condensation of exhaust material on the interior surface.

Abstract: An alert source issues security alerts to an identity provider, which acts as a gatekeeper to a secure resource. Each security alert is associated with an alert user identity and a security threat. When a user identity requests access to the secure resource, the identity provider may look up security alerts associated with the user identity, such as my matching up the user identity with the alert user identity associated with each alert. Based on any discovered security alerts that correspond to the user identity and a pre-defined security policy, the identity provider may perform various security actions on the user identity. For example, the identity provider may contain a user identity associated with high-risk and/or high fidelity security alerts. The identity provider may deny the user identity access to the secure resource, or the identity provider may request additional authentication factors associated with the user identity before access to the secure resource is provided.

Abstract: An alert source issues security alerts to an identity provider, which acts as a gatekeeper to a secure resource. Each security alert is associated with an alert user identity and a security threat. When a user identity requests access to the secure resource, the identity provider may look up security alerts associated with the user identity, such as my matching up the user identity with the alert user identity associated with each alert. Based on any discovered security alerts that correspond to the user identity and a pre-defined security policy, the identity provider may perform various security actions on the user identity. For example, the identity provider may contain a user identity associated with high-risk and/or high fidelity security alerts. The identity provider may deny the user identity access to the secure resource, or the identity provider may request additional authentication factors associated with the user identity before access to the secure resource is provided.

Abstract: A clutch for selectively preventing rotation of a rotating component may include a first and second pawls pivotable between engagement and disengagement with the rotating component to selectively prevent or allow rotation of the rotating component in one or both directions. An armature moveable between a first and second armature positions may have a common member pivotally connected thereto and engaging the first and second pawls, with a torque spring biasing the common member to rotate toward the first pawl and away from the second pawl. In an intermediate armature position, the common member may disengage the first pawl from the rotating component while engaging the second pawl to allow rotation in one direction while preventing rotation in the opposite direction. In embodiments, a clutch may include a cam actuator rotating to selectively control engagement of the pawls with the rotating component and locking in one or both directions.

Abstract: A flexplate assembly (26) for use in a starting system (31) for translating rotational torque between an engine and a transmission includes a drive assembly (28) adapted to be attached to the engine and the transmission for translating rotational torque therebetween. The flexplate assembly (26) also includes a ring assembly (30) having a ring gear (32) adapted to permanently engage a pinion gear (24) of a starter motor (22) of the starting system (31). The ring assembly (30) rotates with the drive assembly (28) in response to rotational torque generated by the pinion gear (24) of the starter motor (22). The drive assembly (28) disengages from the ring assembly (30) in response to rotational torque generated by the engine.

Abstract: A latching solenoid assembly is provided which includes a solenoid actuator. A housing is also provided which has an axial passage. An intermediate piston is moved by the solenoid actuator. A reaction member is also placed within the housing axial passage spring biased by a transfer spring from the intermediate piston. The housing has a latching port allowing pressure to latch the intermediate piston in position to set the force which is transmitted to the reaction member.

Abstract: A system and method are disclosed that enable an email service provider to implement an email forwarding service without losing associated page views. In one embodiment, rather than forwarding the entire email message, the email forwarding service generates a summary email message, and sends this summary email message to the forwarding email address pre-specified by the subscriber. This summary email message includes a link that is selectable by the user to view the original email message on a web site of the email service provider. Thus, even if the forwarding email address is hosted externally, the subscriber still views the full email message on a web site of the provider of the email forwarding service.

Abstract: A multi-mode clutch module includes first and second races, and a plurality of race engagement mechanisms situated between the races. The module incorporates an actuator sleeve having an axially acting actuator cam finger. The cam finger is configured with variable radial thicknesses to provide a plurality of predetermined fixed positions for contacting the race engagement mechanisms to cause the engagement mechanisms to selectively interact with the races. The actuator sleeve is thus adapted to control axial movement of the actuator cam finger between at least two axially spaced positions in one embodiment. In other embodiments within the scope of this disclosure, the actuator cam finger may be adapted to move axially among any number of predetermined positions to operatively permit or prevent transmittal of torque between the first and second races, irrespective of the relative rotational direction of the races.

Abstract: Controlling foam in apparatus downstream of a melter by adjustment of alkali oxide content in the melter. One method includes feeding a feedstock into a submerged combustion melter (SCM) apparatus having an internal space containing a flowing or non-flowing molten mass of foamed glass comprising molten glass and bubbles entrained therein, the molten mass having glass foam comprising glass foam bubbles on at least a portion of a top surface of the molten mass. The molten mass from the SCM is routed to a downstream apparatus, stability of the glass foam in the downstream apparatus is observed, and alkali oxide percentage fed to the SCM apparatus is adjusted based on the observation to positively or negatively affect the foam stability. Systems for carrying out the methods, and the products of the methods are also considered novel and inventive.

Abstract: Channel apparatus for use with submerged combustion systems and methods of use to produce glass. One channel apparatus includes a flow channel defined by a floor, a roof, and a wall structure connecting the floor and roof, the flow channel divided into sections by a series of skimmers. Channel apparatus include both high and low momentum combustion burners, with one or more high momentum combustion burners positioned immediately upstream of each skimmer in either the roof or sidewall structure, or both, and one or more low momentum combustion burners positioned immediately downstream of each skimmer in either the roof, the sidewall structure, or both, and positioned to transfer heat to the molten mass of glass without substantial interference from foamed material. Certain embodiments include increased height of glass-contact refractory, in particular immediately upstream of the skimmers.