Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

Abstract: A method includes inserting an irradiated, cross-linked thermoplastic polymer into a pressure chamber of a pressure molding machine, positioning an oral model on a molding platform of the pressure molding machine, applying heat using a heat element to soften the thermoplastic polymer, and applying pressure to form the thermoplastic polymer over the oral model to produce a tray. The method also includes scanning the tray to produce a scanned surface and milling a frame based on the scanned surface. The frame includes a channel that fits the tray. The method further includes inserting the tray into the channel of the frame and coupling the tray to the frame.

Abstract: An oral appliance includes an upper arch and a seal. The upper arch may be positioned proximate a maxillary dentition of a user. The upper arch includes a first tab and a second tab positioned on opposite sides of a plane substantially bisecting the upper arch. The seal defines a first receptacle and a second receptacle that may receive the first and second tabs to couple the seal to the upper arch and to inhibit breathing through a mouth of the user.

Abstract: An oral appliance includes an upper arched frame, an upper moldable tray coupled to the upper arched frame, a lower arched frame, and a lower moldable tray coupled to the lower arched frame. The upper arched frame includes a first tab and a second tab being positioned, with respect to each other, on opposite sides of a plane substantially bisecting the upper arched frame. The lower arched frame includes a third tab extending from the lower arched frame.

Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

Abstract: An oral appliance includes an upper arched frame, an upper moldable tray coupled to the upper arched frame, a lower arched frame, and a lower moldable tray coupled to the lower arched frame. The upper arched frame includes a first tab and a second tab being positioned, with respect to each other, on opposite sides of a plane substantially bisecting the upper arched frame. The lower arched frame includes a third tab extending from the lower arched frame.

Abstract: An oral appliance includes an upper arch, a lower arch, and an electronic device. The upper arch is configured to be positioned within a user's mouth proximate the user's maxillary dentition when the upper arch is positioned in the user's mouth. The lower arch is configured to be positioned proximate the user's mandibular dentition when the lower arch is positioned in the user's mouth. The electronic device is coupled to one or more of the upper arch and the lower arch, the electronic device configured to monitor a feature of the environment proximate one or more of the upper arch and the lower arch.

Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

Abstract: According to one embodiment, an apparatus for improved breathing is provided. The apparatus may include an improved oral appliance, an improved mask, an improved coupler to couple an oral appliance to a mask, and/or a combination of these improvements.

Abstract: According to one embodiment, an apparatus for improved breathing is provided. The apparatus may include an improved oral appliance, an improved mask, an improved coupler to couple an oral appliance to a mask, and/or a combination of these improvements.

Abstract: According to one embodiment, an apparatus for improved breathing is provided. The apparatus may include an improved oral appliance, an improved mask, an improved coupler to couple an oral appliance to a mask, and/or a combination of these improvements.

Abstract: According to one embodiment, an apparatus for improved breathing is provided. The apparatus may include an improved oral appliance, an improved mask, an improved coupler to couple an oral appliance to a mask, and/or a combination of these improvements.

Abstract: Systems and methods for inflating a tire are described herein. The systems and methods use a centrifugal force acting on a piston or the inertia of the piston to compress air to inflate the tire. Compressed air is ported into the tire, maintaining the pressure of the tire.

Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

Abstract: An oral appliance includes an upper arch, a lower arch, and an electronic device. The upper arch is configured to be positioned within a user's mouth proximate the user's maxillary dentition when the upper arch is positioned in the user's mouth. The lower arch is configured to be positioned proximate the user's mandibular dentition when the lower arch is positioned in the user's mouth. The electronic device is coupled to one or more of the upper arch and the lower arch, the electronic device configured to monitor a feature of the environment proximate one or more of the upper arch and the lower arch.

Abstract: An oral appliance includes an upper arch, a lower arch, and an electronic device. The upper arch is configured to be positioned within a user's mouth proximate the user's maxillary dentition when the upper arch is positioned in the user's mouth. The lower arch is configured to be positioned proximate the user's mandibular dentition when the lower arch is positioned in the user's mouth. The electronic device is coupled to one or more of the upper arch and the lower arch, the electronic device configured to monitor a feature of the environment proximate one or more of the upper arch and the lower arch.

Abstract: In some embodiments, a system for improving a user's breathing includes a mask configured to be positioned on a user's face to deliver gas to the user, a first oral appliance arch configured to be worn in the user's mouth on the user's mandibular dentition, a first tension element coupled to the first oral appliance arch, an adjustment device coupled to the mask, and a control system. The adjustment device is configured to receive the first tension element and to adjust the position of the first tension element to adjust the forward position of the first oral appliance arch, such that the when the mask is positioned on the user's face and the first oral appliance arch is worn on a user's mandibular dentition, the forward position of the user's mandible is adjusted.

Abstract: Nucleic acids sequences that can be used for nucleic acid amplification, for example quantitative nucleic acid amplification, are provided herein.

Abstract: An oral appliance includes an upper arch, a lower arch, and an electronic device. The upper arch is configured to be positioned within a user's mouth proximate the user's maxillary dentition when the upper arch is positioned in the user's mouth. The lower arch is configured to be positioned proximate the user's mandibular dentition when the lower arch is positioned in the user's mouth. The electronic device is coupled to one or more of the upper arch and the lower arch, the electronic device configured to monitor a feature of the environment proximate one or more of the upper arch and the lower arch.

Abstract: An apparatus for improved breathing is provided. The apparatus may include an improved oral appliance, an improved mask, an improved coupler to couple an oral appliance to a mask, and/or a combination of these improvements.