Patents by Inventor Keizo Ito

Keizo Ito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4816313
    Abstract: A soft resin product is described, which comprises a resin main body and a soft resin covering part, wherein said resin main body comprises polyolefin and said soft resin covering part comprises a styrene based thermoplastic elastomer composition having a hardness H.sub.s of 20 to 50.
    Type: Grant
    Filed: September 16, 1987
    Date of Patent: March 28, 1989
    Assignee: Toyoda Gosei Co., Ltd.
    Inventors: Takeshi Hosokawa, Shigeru Yabuya, Keizo Ito, Akiyoshi Nagano, Takaharu Yoshimi, Shoji Sakaida
  • Patent number: 4797400
    Abstract: Novel piperazine compounds of the formula: ##STR1## wherein either one of R.sup.1 and R.sup.2 is methoxy group and another is hydrogen atom, or a pharmaceutically acceptable acid addition salt thereof, which have excellent anti-peptic ulcer activities with potent activity for promoting the action of the defensive factor, and hence are useful as an anti-ulcer agent for the prophylaxis and treatment of peptic ulcers.
    Type: Grant
    Filed: June 16, 1987
    Date of Patent: January 10, 1989
    Assignee: Kanebo, Ltd.
    Inventors: Hiroshi Ohtaka, Kenji Yoshida, Kenji Suzuki, Koichi Shimohara, Sigeru Tajima, Keizo Ito
  • Patent number: 4742062
    Abstract: Novel benzylpiperazine compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, which has excellent hypolipidemic activity without undesirable side effect, and a pharmaceutical composition containing the compound as an active ingredient suitable for the prophylaxis and treatment of hyperlipidemia.
    Type: Grant
    Filed: July 8, 1986
    Date of Patent: May 3, 1988
    Assignee: Kanebo, Ltd.
    Inventors: Hiroshi Ohtaka, Yoichiro Hamada, Akira Yamashita, Keizo Ito, Goro Tsukamoto
  • Patent number: 4703048
    Abstract: A 1-benzhydryl-4-cinnamylpiperazine derivative represented by the following formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a methoxy group, and R.sup.2 represents a hydrogen or fluorine atom, or a pharmaceutically acceptable acid addition salt thereof. The compound (I) is prepared by selectively reducing the corresponding 1-benzhydryl-4-cinnamoylpiperazine derivative and optionally converting the product into its acid addition salt. The compound (I) is useful for treatment of cerebrovascular disease in a human.
    Type: Grant
    Filed: December 31, 1985
    Date of Patent: October 27, 1987
    Assignee: Kanebo Ltd.
    Inventors: Hiroshi Ohtaka, Toshiro Kanazawa, Keizo Ito, Goro Tsukamoto
  • Patent number: 4663325
    Abstract: A 1-benzyl-4-benzhydrylpiperazine derivative represented by the following general formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a methoxy group, andR.sup.2 represents a hydrogen or fluorine atom,or a pharmaceutically acceptable acid addition salt thereof.The 1-benzyl-4-benzhydrylpiperazine derivative or an acid addition salt thereof is prepared by reductively condensing a benzaldehyde derivative with a fluorobenzhydrylpiperazine, or condensing a benzyl halide derivative with a fluorobenzhydrylpiperazine optionally in the presence of an acid acceptor, or condensing a benzylpiperazine with a fluorobenzhydryl halide derivative and, optionally converting the product to its acid addition salt.The 1-benzyl-4-benzhydrylpiperazine derivative is useful for improving a cerebrovascular disease.
    Type: Grant
    Filed: March 25, 1985
    Date of Patent: May 5, 1987
    Assignee: Kanebo Ltd.
    Inventors: Hiroshi Ohtaka, Toshiro Kanazawa, Keizo Ito, Goro Tsukamoto
  • Patent number: 4659726
    Abstract: Novel 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)-thiazoles of the formula: ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, 2,2,2-trifluoroethyl, a group of the formula: --CH.sub.2 COOR.sup.2 R.sup.2 is C.sub.1-8 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, or phenyl-C.sub.1-2 alkyl), or a group of the formula: --(CH.sub.2).sub.n --A--R.sup.3 (A is oxygen or sulfur, R.sup.3 is C.sub.1-4 alkyl or C.sub.2-4 alkenyl, and n is 1, 2 or 3), a process for the preparation of the compounds, and a pharmaceutical composition useful as a platelet aggregation inhibitor which comprises as an active ingredient the above 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazole compound in admixture with a conventional pharmaceutically acceptable carrier or diluent.
    Type: Grant
    Filed: April 12, 1985
    Date of Patent: April 21, 1987
    Assignee: Kanebo, Ltd.
    Inventors: Koichiro Yoshino, Norihiko Seko, Koichi Yokota, Keizo Ito, Goro Tsukamoto
  • Patent number: 4653385
    Abstract: An air intake grille has an air flow guide member mounted on a housing in such a manner that the direction of air flow can be adjusted using a control member. The air flow guide member is constituted by a sheet assembly formed by laminating a multiplicity of perforated sheets. The sheet assembly is retained by retainers in such a manner that the sheets can slide so as to be stepwisely offset from each other. Further, the sheet assembly is mounted on the housing in such a manner as to be pivotal with respect to a fixed plane, which is the front surface of the housing, or a fixed plane parallel to the front surface. The air intake grille with the above arrangement enables the air flow guide member to be orientated to any desired direction in a single operation of the control member.
    Type: Grant
    Filed: September 19, 1985
    Date of Patent: March 31, 1987
    Assignee: Toyoda Gosei Co., Ltd.
    Inventors: Keizo Ito, Syoji Murota
  • Patent number: 4607031
    Abstract: An ethyl benzylphosphinate derivative represented by the general formula (I) ##STR1## wherein Y represents a hydrogen or fluorine atom, X represents a methylene group or an oxygen atom, and n is 2, 3 or 4.The said compounds can be produced by reacting a compound represented by the following formula (II) ##STR2## wherein Y is as defined above, with a compound represented by the following formula (III) ##STR3## wherein X and n are as defined, and M is an alkali metal atom, in an inert medium. These compounds are useful as a calcium antagonist.
    Type: Grant
    Filed: May 22, 1985
    Date of Patent: August 19, 1986
    Assignee: Kanebo Ltd.
    Inventors: Koichiro Yoshino, Tominori Morita, Masaru Moriyama, Keizo Ito, Goro Tsukamoto
  • Patent number: 4603130
    Abstract: Novel benzimidazole derivatives of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group, a lower alkenyl group or a lower alkynyl group, R.sup.2 is hydrogen atom, a lower alkyl group or a lower hydroxyalkyl group, and n is 2 or 3, or a pharmaceutically acceptable acid addition salt thereof, which have potent antihistaminic activity with less toxicity and hence are useful as an antihistaminics, and a process for the preparation of the compounds, and a pharmaceutical composition useful as antihistaminics containing the compound as an essential active ingredient.
    Type: Grant
    Filed: March 28, 1984
    Date of Patent: July 29, 1986
    Assignee: Kanebo, Ltd.
    Inventors: Ryuichi Iemura, Tsuneo Kawashima, Toshikazu Fukuda, Keizo Ito, Takashi Nose, Goro Tsukamoto
  • Patent number: 4561760
    Abstract: An electrophotographic copying machine including a cleaning device for cleaning at least a tip of a separation claw separating a copied paper from a photoreceptor. The separation claw is pivotally moved between a first position separating the copied paper and a second position of cleaning itself by the cleaning device. At least one solenoid is provided for pivotally moving the separation claw between the first position and the second position.
    Type: Grant
    Filed: August 29, 1984
    Date of Patent: December 31, 1985
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Tadaaki Kawano, Keizo Ito, Takashi Nishida
  • Patent number: 4434162
    Abstract: A phosphonic acid ester of the formula ##STR1## exhibits calcium-antagonistic, coronary vasodilating and hypotensive activities. Pharmaceutical compositions containing the same are useful for the prophylaxis and treatment of circulatory organ diseases such as angina pectoris, hypertension and the like.
    Type: Grant
    Filed: April 7, 1982
    Date of Patent: February 28, 1984
    Assignee: Kanebo, Ltd.
    Inventors: Goro Tsukamoto, Toshihiko Kohno, Koichiro Yoshino, Tominori Morita, Keizo Ito, Takashi Nose
  • Patent number: 4430343
    Abstract: Novel benzimidazole derivatives of the formula: ##STR1## wherein R.sup.1 is an alkyl group having 1 to 3 carbon atoms, allyl group, propargyl group, or phenyl group; R.sup.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; and n is 2 or 3, or pharmaceutically acceptable acid addition salts thereof, which have excellent antihistaminic activities and are useful as antiallergics for various allergic diseases, and a process for the preparation thereof, and an antihistaminic composition containing the compound as an active ingredient.
    Type: Grant
    Filed: October 22, 1982
    Date of Patent: February 7, 1984
    Assignee: Kanebo, Ltd.
    Inventors: Ryuichi Iemura, Tsuneo Kawashima, Toshikazu Fukuda, Keizo Ito, Takashi Nose, Goro Tsukamoto
  • Patent number: 4261151
    Abstract: Structure for combining an attaching member of integrally constituted engaging body to a receiving member having a rectangular attaching hole through a clip, wherein the device comprises said engaging body which includes a pair of supporting plates which project at both sides of an engaging hole with both surfaces of the supporting plates in the vertical direction, said engaging hole having one or two engaging pieces at one side or both sides at the inside of the engaging hole, said clip which can be inserted between the supporting plates and includes an elastic head of anchor-like shape, a pair of elastic wings which project from the base portion of the elastic head upward and downward and are curved towards the elastic head, and elastic arms which project from the base portion of the elastic head in the reverse direction to the elastic head, engaging stepped portion at the free end of the cantilever of the elastic head, a pawl at the top end of the elastic arm.
    Type: Grant
    Filed: March 28, 1979
    Date of Patent: April 14, 1981
    Assignee: Toyoda Gosei Co., Ltd.
    Inventor: Keizo Ito
  • Patent number: 4192880
    Abstract: 2-Substituted benzimidazole compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, lower alkyl or lower alkoxy, and R.sub.2 is hydrogen or lower alkyl with the proviso that R.sub.1 and R.sub.2 do not stand for hydrogen simultaneously and, when R.sub.1 is hydrogen, R.sub.2 cannot mean a methyl group at 6th position on the pyridin-2-yl group or methyl an isobutyl group on the phenyl group; are useful as anti-inflammatory agents and/or analgesics.
    Type: Grant
    Filed: October 10, 1978
    Date of Patent: March 11, 1980
    Assignee: Kanebo, Ltd.
    Inventors: Goro Tsukamoto, Koichiro Yoshino, Toshihiko Kohno, Masahiro Taguchi, Katsumi Dezawa, Hajime Kagaya, Keizo Ito, Takashi Nose
  • Patent number: 4114339
    Abstract: Structure for combining a to-be-attached member with an attaching member and sheeting through a clip comprising an annular elastic head and one or a pair of elastic arms projectingly elongated from the center base portion of the elastic head and an engaging body having a supporting plate on the base portion, which projectingly elongated from both right and left sides of the back side of an engaging hole, wherein a to-be-attached hole is arranged on the to-be-attached member, the elastic head being fitted into the to-be-attached hole unmovably to the front and rear, with the supporting plate fitted unmovably to ups and downs and the elastic arm fitted into said engaging hole unmovably to the front and rear, and in case of combining the attaching member the same is made to be integral with the engaging body and in case of combining with sheeting a combining hole is punched on sheeting and the elastic head and supporting plate being inserted into the combining hole and sheeting being held between the to-be-attac
    Type: Grant
    Filed: April 28, 1977
    Date of Patent: September 19, 1978
    Assignee: Toyoda Gosei Co., Ltd.
    Inventor: Keizo Ito