Patents by Inventor Kelly Byrnes-Blake

Kelly Byrnes-Blake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230257428
    Abstract: Compositions, formulations, and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes or conjugated to cytotoxic agents. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are provided.
    Type: Application
    Filed: January 27, 2023
    Publication date: August 17, 2023
    Inventors: Dennis M. Miller, Kelly Byrnes-Blake
  • Publication number: 20230211000
    Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
    Type: Application
    Filed: August 15, 2022
    Publication date: July 6, 2023
    Inventors: Stacey J. Hansen, Claudia Jochheim, Dennis M. Miller, Natalie Winblade Nairn, Julia E. Novak, Mark R. Stroud, Valorie R. Wiss, Kelly Byrnes-Blake, Scott Presnell
  • Patent number: 11559580
    Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
    Type: Grant
    Filed: August 23, 2021
    Date of Patent: January 24, 2023
    Assignee: BLAZE BIOSCIENCE, INC.
    Inventors: Stacey J. Hansen, Claudia Jochheim, Dennis M. Miller, Natalie Winblade Nairn, Julia E. Novak, Mark R. Stroud, Valorie R. Wiss, Kelly Byrnes-Blake, Scott Presnell
  • Publication number: 20200188536
    Abstract: Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are also provided.
    Type: Application
    Filed: December 5, 2019
    Publication date: June 18, 2020
    Inventors: Stacey J. Hansen, Claudia Jochheim, Dennis M. Miller, Natalie Nairn, Julia E. Novak, Mark Stroud, Valorie R. Wiss, Kelly Byrnes-Blake
  • Publication number: 20190161523
    Abstract: Compositions, formulations, and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes or conjugated to cytotoxic agents. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are provided.
    Type: Application
    Filed: April 12, 2017
    Publication date: May 30, 2019
    Inventors: Dennis M. Miller, Kelly Byrnes-Blake
  • Publication number: 20160096869
    Abstract: Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are also provided.
    Type: Application
    Filed: September 15, 2015
    Publication date: April 7, 2016
    Inventors: Stacey J. Hansen, Claudia Jochheim, Dennis M. Miller, Natalie Nairn, Julia E. Novak, Mark Stroud, Valorie R. Wiss, Kelly Byrnes-Blake
  • Publication number: 20100092465
    Abstract: Methods for treating graft-versus-host disease, methods for reducing symptoms of graft-versus-host disease, and methods of reducing the severity of graft-versus-host disease in a patient are disclosed. The methods comprise administering to the patient a therapeutically effective amount of an IL-27 antagonist in combination with a pharmaceutically acceptable vehicle. IL-27 antagonists include soluble IL-27RA proteins and antagonists that comprise an antigen-binding site of an antibody.
    Type: Application
    Filed: August 27, 2007
    Publication date: April 15, 2010
    Inventors: Nancy Hosken, Kelly Byrnes-Blake, Ty Brender, Monica Huber, Margaret Moore, Shirley Rene, Mark Rixon, Sara Underwood, Kimberly Waggie
  • Publication number: 20100008917
    Abstract: Methods of treating aplastic anemia in a patient and of increasing blood cell production in a patient having aplastic anemia are disclosed. The methods comprise administering to the patient a therapeutically effective amount of an IL-27 antagonist in combination with a pharmaceutically acceptable vehicle. IL-27 antagonists include soluble IL-27RA proteins and antagonists that comprise an antigen-binding site of an antibody.
    Type: Application
    Filed: August 27, 2007
    Publication date: January 14, 2010
    Inventors: Nancy Hosken, Kelly Byrnes-Blake, Ty Brender, Monica J. Huber, Margaret D. Moore, Shirley Rene, Mark W. Rixon, Sara Underwood