Patents by Inventor Kelly M. Aubart

Kelly M. Aubart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide deformylase inhibitors
    Patent number: 8901119
    Abstract: The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: December 2, 2014
    Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
    Inventors: Kelly M. Aubart, Andrew B. Benowitz, Yuhong Fang, James Hoffman, Joseph M. Karpinski, Andrew Nicholson Knox, Xiangmin Liao, Donghui Qin, Dongchuan Shi, Jared T. Spletstoser
  • PEPTIDE DEFORMYLASE INHIBITORS
    Publication number: 20130345120
    Abstract: The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
    Type: Application
    Filed: March 9, 2012
    Publication date: December 26, 2013
    Applicant: Glaxosmithkline LLC
    Inventors: Kelly M. Aubart, Andrew B. Benowitz, Yuhong Fang, James Hoffman, Joseph M. Karpinski, Andrew Nicholson Knox, Xiangmin Liao, Donghui Qin, Dongchuan Shi, Jared T. Spletstoser
  • PEPTIDE DEFORMYLASE INHIBITORS
    Publication number: 20130045962
    Abstract: The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined below and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.
    Type: Application
    Filed: November 6, 2008
    Publication date: February 21, 2013
    Inventors: Donghui Qin, Beth Norton, Xiangmin Liao, Andrew Nicholson Knox, Jinhwa Lee, Yuhong Fang, Jason Christopher Dreabit, Siegfried Benjamin Christensen, IV, Andrew B. Benowitz, Kelly M. Aubart
  • Peptide deformylase inhibitors
    Patent number: 7919528
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: April 5, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Kelly M. Aubart, Andrew B. Benowitz, Siegfried B. Christensen, IV, Joseph M. Karpinski, Jinhwa Lee, Domingos J. Silva
  • Peptide deformylase inhibitors
    Patent number: 7893056
    Abstract: The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: February 22, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Donghui Qin, Beth Norton, Andrew Nicholas Knox, Siegfried B. Christensen, Kelly M. Aubart
  • Peptide deformylase inhibitors
    Patent number: 7745637
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: June 29, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: Kelly M. Aubart, Ajita Bhat, Sigfried B. Christensen, IV, Jack D. Leber, Xiangmin Liao
  • PEPTIDE DEFORMYLASE INHIBITORS
    Publication number: 20090306066
    Abstract: The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.
    Type: Application
    Filed: November 6, 2008
    Publication date: December 10, 2009
    Inventors: Donghui Qin, Beth Norton, Andrew Nicholas Knox, Siegfried B. Christensen, Kelly M. Aubart
  • Peptide deformylase inhibitors
    Patent number: 7507726
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: March 24, 2009
    Assignee: SmithKlineBeecham Corporation
    Inventors: Kelly M. Aubart, Andrew B. Benowitz, Siegfried B. Christensen, IV, Jinhwa Lee, Domingos J. Silva
  • Peptide deformylase inhibitors
    Patent number: 7456211
    Abstract: The present invention involves novel anti-bacterial compounds represented by Formula (I), pharmaceutical compositions thereof, their use as PDF inhibitors, and their use in the treatment of bacterial infections.
    Type: Grant
    Filed: March 7, 2007
    Date of Patent: November 25, 2008
    Assignee: SmithKline Beecham Corp
    Inventors: Kelly M. Aubart, Jia-Ning Xiang, Siegfried B. Christensen, IV, Xiangmin Liao, Maxwell D. Cummings
  • Peptide Deformylase Inhibitors
    Publication number: 20080167302
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: August 12, 2004
    Publication date: July 10, 2008
    Inventors: Kelly M. Aubart, Andrew B. Benowitz, Siegfried B. Christensen IV, Jinhwa Lee, Domingos J. Silva
  • Peptide deformylase inhibitors
    Patent number: 7332485
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: February 19, 2008
    Assignee: SmithKline Beecham Corp
    Inventors: Kelly M. Aubart, Siegfried Benjamin Christensen, IV, Chaya Duraiswami, Joseph M. Karpinski
  • Peptide deformylase inhibitors
    Patent number: 7166624
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: January 23, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Jack Dale Leber, Mei Li, Jinhwa Lee, Kelly M. Aubart, Siegfried B. Christensen, IV
  • Peptide deformylase inhibitors
    Patent number: 7115605
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: April 5, 2004
    Date of Patent: October 3, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Kelly M. Aubart, Siegfried B. Christensen, IV, Jacques Briand, Maxwell David Cummings
  • Peptide deformylase inhibitors
    Patent number: 6806369
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: October 19, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Kelly M. Aubart, Siegfried B. Christensen, IV, Jacques Briand, Maxwell David Cummings
  • Peptide deformylase inhibitors
    Publication number: 20040192719
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: April 5, 2004
    Publication date: September 30, 2004
    Applicant: SmithKline Beecham Corporation
    Inventors: Kelly M. Aubart, Siegfried B. Christensen, Jacques Briand, Maxwell David Cummings
  • Peptide deformylase inhibitors
    Publication number: 20040097732
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: August 28, 2003
    Publication date: May 20, 2004
    Inventors: Kelly M Aubart, Jia-Ning Xiang, Siegfried B Christensen, XIangmin Liao, Maxwell D Cummings
  • Peptide deformylase inhibtors
    Publication number: 20040053932
    Abstract: The present invention involves novel anti-bacterial compounds represented by Formula (I) hereinbelow and their use as PDF inhibitors.
    Type: Application
    Filed: November 5, 2002
    Publication date: March 18, 2004
    Inventors: Kelly M. Aubart, Siegfried B. Christensen IV, Jacques Briand, Maxwell David Cummings
  • AXOR35, a G-protein coupled receptor
    Publication number: 20040043393
    Abstract: AXOR35 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR35 polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: January 21, 2003
    Publication date: March 4, 2004
    Inventors: Kelly M. Aubart, Derk J. Bergsma, Laura Fitzgerald, Todd L. Graybill, Xiaotong Li, David Michalovich, Dwight M. Morrow, Yuan Zhu
  • Peptide deformylase inhibitors
    Publication number: 20040034024
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: November 5, 2002
    Publication date: February 19, 2004
    Inventors: Kelly M Aubart, Siegfried B Christensen, Jacques Briand, Maxwell David Cummings
  • Compounds and their use as PDE inhibitors
    Patent number: 6617357
    Abstract: This invention relates to certain benzenesulfonamides and their use as PDE7 inhibitors.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: September 9, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Kelly M. Aubart, Siegfried B. Christensen, IV, Jack D. Leber