Patents by Inventor Kelvin Lam
Kelvin Lam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160264939Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.Type: ApplicationFiled: October 13, 2015Publication date: September 15, 2016Inventors: Shuibing C. Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo Fox, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin
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Patent number: 9157062Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.Type: GrantFiled: May 20, 2014Date of Patent: October 13, 2015Assignee: President and Fellows of Harvard CollegeInventors: Shuibing C. Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo Fox, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L Rubin
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Publication number: 20140335611Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.Type: ApplicationFiled: May 20, 2014Publication date: November 13, 2014Applicants: President and Fellows of Harvard College, The General Hospital CorporationInventors: Shuibing C. Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin
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Patent number: 8728812Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.Type: GrantFiled: April 22, 2009Date of Patent: May 20, 2014Assignees: President and Fellows of Harvard College, The General Hospital CorporationInventors: Shuibing Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin
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Publication number: 20130259842Abstract: The present invention relates to a stable pluripotent reprogrammed cells, and compositions and methods of isolation and uses thereof, wherein the stable pluripotent reprogrammed cells is derived from a somatic cell and has undergone incomplete remodeling of the epigenome. In some embodiments, the stable reprogrammed cell is a human stable reprogrammed cell. In some embodiments, the stable reprogrammed cell has a statistically significant lower level of expression of one or any combination of Nanog, Dnmt3b, Lefty2 as compared to an induced pluripotent stem cell. In some embodiments, the stable reprogrammed cell has a statistically significant higher level of expression of one or any combination of Tdgf1, Tert or endogenous Sox2 as compared to a somatic cell from which it was derived. In some embodiments, the stable reprogrammed cell has a statistically significant faster rate of doubling as compared to an induced pluripotent stem cell (iPSC) or an embryonic stem (ES) cell.Type: ApplicationFiled: May 18, 2011Publication date: October 3, 2013Inventors: Lee Rubin, Joel Blanchard, Kelvin Lam
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Patent number: 8219541Abstract: A system and method for automatically detecting, reporting, and tracking conflicts in a change management system is provided. In particular, the system and method described herein may be used to identify potential conflicts associated with resources and schedules involved in a proposed change to an information technology infrastructure. A conflict analysis engine may analyze a change order that includes planned changes to an information technology infrastructure to identify potential conflicts associated with the change order that includes the planned changes to the information technology infrastructure. The potential conflicts may then be added to a conflicts list for the change order and a workflow may be created to manage resolving the potential conflicts. Thus, in response to resolving the potential conflicts, the planned changes may be deployed within the information technology infrastructure.Type: GrantFiled: October 28, 2009Date of Patent: July 10, 2012Assignee: CA, Inc.Inventors: Richard Kevin Magnuson, Stephen J. Siwek, Kelvin Lam, Rashmi Rekha Sahoo, A. V. S. S. N. S. Sudhakar, David Andrew Tootill
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Publication number: 20120021519Abstract: The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-?-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof.Type: ApplicationFiled: September 21, 2009Publication date: January 26, 2012Applicant: PRESIDENTS AND FELLOWS OF HARVARD COLLEGEInventors: Justin Ichida, Joel Blanchard, Lee Rubin, Kevin Eggan, Kelvin Lam
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Publication number: 20110099158Abstract: A system and method for automatically detecting, reporting, and tracking conflicts in a change management system is provided. In particular, the system and method described herein may be used to identify potential conflicts associated with resources and schedules involved in a proposed change to an information technology infrastructure. A conflict analysis engine may analyze a change order that includes planned changes to an information technology infrastructure to identify potential conflicts associated with the change order that includes the planned changes to the information technology infrastructure. The potential conflicts may then be added to a conflicts list for the change order and a workflow may be created to manage resolving the potential conflicts. Thus, in response to resolving the potential conflicts, the planned changes may be deployed within the information technology infrastructure.Type: ApplicationFiled: October 28, 2009Publication date: April 28, 2011Applicant: Computer Associates Think, Inc.Inventors: Richard Kevin Magnuson, Stephen J. Siwek, Kelvin Lam, Rashmi Rekha Sahoo, A.V.S.S.N.S. Sudhakar, David Andrew Tootill
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Publication number: 20110070645Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.Type: ApplicationFiled: April 22, 2009Publication date: March 24, 2011Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATIONInventors: Shuibing Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin
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Patent number: 7418695Abstract: Methods, systems, apparatus and computer-readable media are disclosed for providing cross-platform software dependency information. A first exemplary method is disclosed that includes receiving a request for software dependency information relating to a number of platforms. The method also includes identifying a set of applications, each application corresponding to a one of the set of platforms. The method further includes transmitting to each of the identified applications a platform-specific software dependency query. A response to each platform-specific software dependency query is received from each of the identified applications, and the are combined into a combined query result. The method still further includes transmitting the combined query result containing the software dependency information in response to the initial query. Other methods, apparatus, systems and computer readable media are disclosed for presenting cross-platform software dependency information.Type: GrantFiled: July 9, 2004Date of Patent: August 26, 2008Assignee: Computer Associates Think, Inc.Inventors: Kelvin Lam, Susan Cohan, Melissa A. Borza
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Publication number: 20070135457Abstract: The invention provides compounds of formula (I) prodrugs thereof, and the pharmaceutically acceptable salts of the compounds or prodrugs, wherein n, X, and Y are as defined herein; pharmaceutical compositions thereof; combinations thereof; and uses thereof.Type: ApplicationFiled: December 6, 2004Publication date: June 14, 2007Inventors: Thomas Beyer, Robert Chambers, Kelvin Lam, Mei Li, Andrew Morrell, David Thompson
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Publication number: 20050138151Abstract: Methods, systems, apparatus and computer-readable media are disclosed for providing cross-platform software dependency information. A first exemplary method is disclosed that includes receiving a request for software dependency information relating to a number of platforms. The method also includes identifying a set of applications, each application corresponding to a one of the set of platforms. The method further includes transmitting to each of the identified applications a platform-specific software dependency query. A response to each platform-specific software dependency query is received from each of the identified applications, and the are combined into a combined query result. The method still further includes transmitting the combined query result containing the software dependency information in response to the initial query. Other methods, apparatus, systems and computer readable media are disclosed for presenting cross-platform software dependency information.Type: ApplicationFiled: July 9, 2004Publication date: June 23, 2005Inventors: Kelvin Lam, Susan Cohan, Melissa Borza
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Patent number: 6274596Abstract: Disclosed are pharmaceutical compositions and formulations comprising benzoquinoline derivatives having the formula (I) to (V), wherein formula (I) is: X is selected from the group consisting of O, S, CH2, CH2-CH2, C═O or NRB; Y is C or N; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, linear or branched chain lower alky, alkenyl, alkynyl, alkoxy or acyl; X-RA and R3, or R3 and R4, are optionally linked together to form a C3-C4 alkylene bridge, where X is CH2 or C═O; provided that: when X is NRB, then (a) RB is hydrogen, and RA is a linear or branched chain lower alkyl, aryl, heteroaryl, cycloalkyl or cycloalkenyl optionally interrupted by at least one heteroatom, said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or cycloalkenyl being optionally substituted singly or plurally by at least one of a linear or branched chain lower alkyl, alkenyl, alkynyl, acyl, alkoxy, or cycloalkyl optionally interrupted by at least one heterType: GrantFiled: October 6, 1999Date of Patent: August 14, 2001Assignee: Anadys Pharmaceuticals, Inc.Inventors: Kelvin Lam, Vincent Boyd, Yi Bin Xiang
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Patent number: 6194399Abstract: Disclosed are pharmaceutical compositions and formulations comprising the compound: wherein: (a) R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, or optionally substituted alkyl, aryl, vinyl, alkyl(aryl), vinyl(aryl), amine, amide; or at least one of R1 and R2, together, and R3 and R4, together, form an optionally substituted ring system, wherein the ring system is optionally interrupted by at least one heteroatom; (b) X is hydrogen, NO2, CN, halogen, OH, SO2, alkyl, alkoxy, or vinyl; and (c) wherein when R1, R2, R3, and R4 are alkyl, aryl, vinyl, alkyl(aryl), vinyl(aryl), amine or amide, R1, R2, R3, and R4 are optionally interrupted with at least one heteroatom, or a salt thereof; and a pharmaceutically acceptable carrier or diluent. Also disclosed are methods of inhibiting microbial replication and treating microbial infections, comprising administration of a pharmaceutical composition or formulation of the invention.Type: GrantFiled: October 6, 1999Date of Patent: February 27, 2001Assignee: Scriptgen Pharmaceuticals, Inc.Inventors: Kelvin Lam, Yi Bin Xiang