Abstract: The present invention relates to the branches of Biotechnology and Medicine. It describes the use of therapeutic compositions comprising a compound that blocks epidermal growth factor and an antibody that blocks the PD-1/PD-1 ligand signaling pathway in the treatment of tumors of epithelial origin, particularly those that express the native form for human KRAS protein. In patients with cancer of epithelial origin expressing native KRAS treated with said therapeutic compositions, an increase in their survival was observed.

Abstract: A hair conditioner composition comprising: a) a fatty acid; b) a fatty alcohol; and c) an antimicrobial system comprising: i) glyceryl caprylate; and ii) one or more of 4-hydroxyacetophenone and pentylene glycol.

Abstract: Disclosed is a dissolvable solid article, comprising by weight of the article: from about 10% to about 50% of a water soluble polymer; from about 20% to about 80% of a surfactant; from about 0.5% to about 2% of diaminocarboxylic acid chelants and salts thereof having an average molecular weight in acid form of from about 250 to about 450 daltons and having a weighted log P value at pH 4 of from about ?12 to about ?7; from about 0.1% to about 6% of an aromatic carboxylic acid and salts thereof having an average molecular weight in acid form of from about 100 to about 400 daltons and having a weighted log P value at pH 4 of from about ?2 to about 4; from about 0.1% to about 18% of an non-aromatic organic alpha hydroxy acid and salts thereof; wherein the dissolvable solid article has a pH of from about 3 to about 5.1 when dissolved with 30 parts water to 1 part of the dissolvable solid article.

Abstract: The present invention is related to the fields of Biotechnology and Medicine. Particularly, it describes the use of epidermal growth factor (EGF) deprivation agents that contribute to lowering and/or depleting serum epidermal growth factor levels, which has implications in the treatment of the chronic obstructive pulmonary disease. These agents can be vaccine compositions comprising as active principle the conjugate between recombinant human EGF and a carrier protein.

Abstract: An example electronic security tag attachable to an item includes a tag body member, a connecting member having a pin portion releasably engageable with the tag body member, the pin portion extending along a first axis. The electronic security tag further includes a locking member to lock the connecting member to the tag body member. The locking member includes a clutch mechanism movable parallel to the first axis between a first position in contact with the pin portion and corresponding to a locked state and a second position corresponding to an unlocked state. The locking member further including a rotational drive member configured to rotate and interact with a plunger member of the clutch mechanism to move the clutch mechanism from the locked state to the unlocked state.

Abstract: A switched capacitor modulator (SCM) includes a RF power amplifier. The RF power amplifier receives a rectified voltage and a RF drive signal and modulates an input signal in accordance with the rectified voltage to generate a RF output signal to an output terminal. A reactance in parallel with the output terminal is configured to vary in response to a control signal to vary an equivalent reactance in parallel with the output terminal. A controller generates the control signal and a commanded phase. The commanded phase controls the RF drive signal. The reactance is at least one of a capacitance or an inductance, and the capacitance or the inductance varies in accordance with the control signal.

Abstract: A switched capacitor modulator (SCM) includes a RF power amplifier. The RF power amplifier receives a rectified voltage and a RF drive signal and modulates an input signal in accordance with the rectified voltage to generate a RF output signal to an output terminal. A reactance in parallel with the output terminal is configured to vary in response to a control signal to vary an equivalent reactance in parallel with the output terminal. A controller generates the control signal and a commanded phase. The commanded phase controls the RF drive signal. The reactance is at least one of a capacitance or an inductance, and the capacitance or the inductance varies in accordance with the control signal.

Abstract: A translucent hair care composition comprising a substituted 2-pyridinol-N-oxide material, a cationic surfactant, a fatty alcohol, a water-soluble polymer, water, and a monocarboxylic acid.

Abstract: A dissolvable solid article, comprising: water soluble polymer; a surfactant; at least one selected from diaminocarboxylic acid chelants and salts thereof; at least one selected from aromatic carboxylic acids and salts thereof; a phenolic derivative; at least one selected from ?, ?-unsaturated Aliphatic Carboxylic Acids, salts, and derivatives thereof; at least one selected from non-aromatic organic alpha hydroxy acids and salts thereof; wherein the dissolvable solid article has a pH of from about 3 to about 5.5 when dissolved with 20 parts water to 1 part of the dissolvable solid article. The present invention provides dissolvable solid articles which provide preservative efficacy even after dissolution of the articles, while controlling the concentrations of preservative ingredients in the solid articles.

Abstract: A switched capacitor modulator (SCM) includes a RF power amplifier. The RF power amplifier receives a rectified voltage and a RF drive signal and modulates an input signal in accordance with the rectified voltage to generate a RF output signal to an output terminal. A reactance in parallel with the output terminal is configured to vary in response to a control signal to vary an equivalent reactance in parallel with the output terminal. A controller generates the control signal and a commanded phase. The commanded phase controls the RF drive signal. The reactance is at least one of a capacitance or an inductance, and the capacitance or the inductance varies in accordance with the control signal.

Abstract: Disclosed is a dissolvable solid article, comprising by weight of the article: from about 10% to about 50% of a water soluble polymer; from about 20% to about 80% of a surfactant; from about 0.5% to about 2% of diaminocarboxylic acid chelants and salts thereof having an average molecular weight in acid form of from about 250 to about 450 daltons and having a weighted log P value at pH 4 of from about ?12 to about ?7; from about 0.1% to about 6% of an aromatic carboxylic acid and salts thereof having an average molecular weight in acid form of from about 100 to about 400 daltons and having a weighted log P value at pH 4 of from about ?2 to about 4; from about 0.1% to about 18% of an non-aromatic organic alpha hydroxy acid and salts thereof; wherein the dissolvable solid article has a pH of from about 3 to about 5.1 when dissolved with 30 parts water to 1 part of the dissolvable solid article.

Abstract: A hair conditioner composition comprising: a) a fatty acid; b) a fatty alcohol; and c) an antimicrobial system comprising: i) glyceryl caprylate; and ii) one or more of 4-hydroxyacetophenone and pentylene glycol.

Abstract: The present invention provides a recombinant eukaryotic cell expressing one or more heterologous double strand break (DSB) repair proteins in an amount effective for enhancing DSB repair in the cell. The recombinant eukaryotic cell may express a recombinant product of interest. Also provided are methods for enhancing double strand break (DSB) repair in eukaryotic cells, establishing host cells for production of a recombinant product of interest, producing a recombinant product of interest, improving production of a recombinant product of interest by eukaryotic cells, and/or investigating suitability of eukaryotic cells as host cells for producing a recombinant product of interest.

Abstract: This document describes a wedge apparatus for retail device display. The techniques described herein provide a seamless graphic panel on an attachment surface that can be used to present any one of a plurality of different hardware devices on a complex plastic-injection molded assembly. The attachment surface of the wedge apparatus includes a single surface with a plurality of hole patterns, each usable for mounting a different hardware device for retail display. The wedge apparatus provides connection points for attachment of an interchangeable graphic panel, which includes a single hole-pattern accommodating one of the plurality of devices to be displayed. The seamless joining of the various parts of the wedge apparatus enables the graphic panel to be wrapped around the wedge apparatus without a seam being visible through the material of the graphic panel.

Abstract: The present invention provides a recombinant eukaryotic cell expressing one or more heterologous double strand break (DSB) repair proteins in an amount effective for enhancing DSB repair in the cell. The recombinant eukaryotic cell may express a recombinant product of interest. Also provided are methods for enhancing double strand break (DSB) repair in eukaryotic cells, establishing host cells for production of a recombinant product of interest, producing a recombinant product of interest, improving production of a recombinant product of interest by eukaryotic cells, and/or investigating suitability of eukaryotic cells as host cells for producing a recombinant product of interest.