Abstract: The present invention relates to a carrier for bio-related molecule immobilization, which comprises a resin substrate, an amino group-containing compound layer that is formed on the resin substrate, and a polyvalent carboxylic acid layer that is formed on the amino group-containing compound layer. The carboxyl groups in the polyvalent carboxylic acid layer are actively esterified; and the (COO peak intensity)/(C—C peak intensity) ratio of the C1s spectrum is from 0.064 to 0.12 (inclusive) if the carrier surface before the active esterification is measured by X-ray photoelectron spectroscopy.

Abstract: The present invention relates to a carrier for bio-related molecule immobilization comprising: a resin substrate; an amino group-containing compound layer formed on the resin substrate; and a polyvalent carboxylic acid layer formed on the amino group-containing compound layer, wherein a carboxyl group of the polyvalent carboxylic acid layer is subjected to active esterification, wherein the resin substrate contains an inorganic pigment, and wherein the resin substrate has a centerline surface average roughness Ra of 60 nm or less.

Abstract: A cell culture apparatus including cell culture units U and a measurement part (5). The measurement part (5) is provided with an imaging part (51) and is disposed so as to be capable of moving up and down between a back panel part (21) of a casing (2) and a culture container accommodating shelf (32). When the measurement unit (5) reaches a measurement position of each cell culture unit U which is a measurement subject, the culture container accommodating shelf (32) slides toward the measurement unit (5) so that portions to be measured of culture containers U20, U30 in each cell culture unit U come in an imaging range of the imaging part (51).

Abstract: Provided is a mass culture method for cells, which uses a culture vessel having flexibility, can form cell aggregates as needed, and is reduced in contamination risk. A pressure is applied onto a culture vessel, which has flexibility, is filled with cells and a culture fluid, and is placed on a placement surface having one or more depressions. With recessed and projected portions, which conform to the depressions, being formed on and in an outer surface of the culture fluid vessel under the application of the pressure, the cells in the culture vessel are cultured.

Abstract: The present invention relates to a carrier for bio-related molecule immobilization, which comprises a resin substrate, an amino group-containing compound layer that is formed on the resin substrate, and a polyvalent carboxylic acid layer that is formed on the amino group-containing compound layer. The carboxyl groups in the polyvalent carboxylic acid layer are actively esterified; and the (COO peak intensity)/(C—C peak intensity) ratio of the C1s spectrum is from 0.064 to 0.12 (inclusive) if the carrier surface before the active esterification is measured by X-ray photoelectron spectroscopy.

Abstract: A cell culture apparatus in which on an abutting surface (2a) around an opening part of a thermostatic chamber (3) and a cold storage chamber (4) that abuts against packing elements (3b, 4b) when front doors (3a, 4a) are closed, a communication groove (5) is provided that intercommunicates the inside and outside of the thermostatic chamber (3) by a communication groove (51) when a transfer tube (U40) is removed. The shut-off mechanism (5) is formed of: a guide hole (52) that opens on the abutting surface (2a) across the communication groove (51) and is deeper than the communication groove (51); a shutter member (53) which is inserted into the guide hole (52) and moves between the blocking position blocking the communication groove (51) and the opening position opening the communication groove (51); and a spring member (54) energizing the shutter member (53) to the blocking position.

Abstract: A cell culture apparatus including cell culture units U and a measurement part (5). The measurement part (5) is provided with an imaging part (51) and is disposed so as to be capable of moving up and down between a back panel part (21) of a casing (2) and a culture container accommodating shelf (32). When the measurement unit (5) reaches a measurement position of each cell culture unit U which is a measurement subject, the culture container accommodating shelf (32) slides toward the measurement unit (5) so that portions to be measured of culture containers U20, U30 in each cell culture unit U come in an imaging range of the imaging part (51).

Abstract: A cell culture system includes a culture medium container to supply a culture medium to a culture container, two culture containers for cell culture, and a transfer tube to connect these containers, whereby liquid delivery is performed by one pump. The containers are connected to the transfer tube; the one pump is attached to the transfer tube; the second culture container is connected to the transfer tube on both sides of the pump to connect the second culture container and the transfer tube, to inject cells into the first culture container; the culture medium is transferred from the culture medium container to the first culture container by the pump; after the cell culture in the first culture container, a cell suspension is transferred from the first culture container to the second culture container; and the culture medium is transferred from the culture medium container to the second culture container.