Abstract: An object of the present invention is to synthesize a novel vitamin D3 derivative having a substituent at the 2?-position. The present invention provides vitamin D derivatives represented by-Formula (I): wherein R1 represents a saturated aliphatic C1-15hydrocarbon group optionally substituted with 1 to 3 hydroxy or protected hydroxy groups; and R2 represents a saturated aliphatic C1-10hydrocarbon group optionally substituted with one or more substituents, which may be the same or different and which are selected from the group consisting of a hydroxy group, a halogen atom, a cyano group, a lower alkoxy group, an amino group and an acylamino group, provided that when R2 represents a saturated aliphatic C1hydrocarbon group, R2 is substituted with at least one substituent.