Patents by Inventor Kenichi Tomioka
Kenichi Tomioka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5177215Abstract: Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis (SRS-A).Type: GrantFiled: February 28, 1990Date of Patent: January 5, 1993Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kiyoshi Murase, Toshiyasu Mase, Hiromu Hara, Kenichi Tomioka
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Patent number: 5140046Abstract: Novel phenylene derivatives shown by the general formula ##STR1## where A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R.sub.1 represents a hydrogen atom or a lower alkoxy group, X.sub.1 represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CONH--, B represents ##STR2## wherein R.sub.2 represents a hydrogen atom, a halogen atom, a nitro group, etc.), ##STR3## (wherein R.sub.3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X.sub.2 represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or ##STR4## which are useful as drugs, particularly SRS-A(slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.Type: GrantFiled: August 13, 1990Date of Patent: August 18, 1992Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Toshiyasu Mase, Kiyoshi Murase, Hiromu Hara, Kenichi Tomioka
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Patent number: 5116853Abstract: Novel phenylene derivatives shown by the general formula ##STR1## wherein A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R.sub.1 represents a hydrogen atom or a lower alkoxy group, X.sub.1 represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CONH--, B represents ##STR2## (wherein R.sub.2 represents a hydrogen atom, a halogen, atom, a nitro group, etc.), ##STR3## (wherein R.sub.3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X.sub.2 represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or ##STR4## which are useful as drugs, particularly SRS-A (slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.Type: GrantFiled: September 27, 1989Date of Patent: May 26, 1992Inventors: Toshiyasu Mase, Kiyoshi Murase, Hiromu Hara, Kenichi Tomioka
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Patent number: 4994479Abstract: Novel phenylene derivatives shown by the general formula ##STR1## wherein A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R.sub.1 represents a hydrogen atom or a lower alkoxy group, X.sub.1 represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CONH--, .circle.B represents ##STR2## (wherein R.sub.2 represents a hydrogen atom, a halogen atom, a nitro group, etc.), ##STR3## (wherein R.sub.3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X.sub.2 represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or ##STR4## which are useful as drugs, particularly SRS-A (slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.Type: GrantFiled: August 15, 1986Date of Patent: February 19, 1991Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Toshiyasu Mase, Kiyoshi Murase, Hiromu Hara, Kenichi Tomioka
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Patent number: 4987132Abstract: A saturated heterocyclic carboxamide derivative of the following general formula (I) and salts thereof which have platelet activating factor (PAF) antagonizing activity.Type: GrantFiled: August 16, 1988Date of Patent: January 22, 1991Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Toshiyasu Mase, Hiromu Hara, Hitoshi Nagaoka, Takumi Takahashi, Takeshi Suzuki, Kenichi Tomioka, Toshimitsu Yamada
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Patent number: 4933348Abstract: This invention relates to novel heterocyclic compounds structurally characterized by containing a specific heterocyclic group and by the presence of --CH.sub.2 --S-- directly bound to the specific heterocyclic group. These heterocyclic compounds are useful as medicines, particularly as antagonists of SRS-A (slow reacting substance of anaphylaxis).Type: GrantFiled: August 4, 1988Date of Patent: June 12, 1990Inventors: Toshiyasu Mase, Ryuji Tsuzuki, Hiromu Hara, Kiyoshi Murase, Kenichi Tomioka
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Patent number: 4908368Abstract: Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis(SRS-A).Type: GrantFiled: June 7, 1989Date of Patent: March 13, 1990Inventors: Kiyoshi Murase, Toshiyasu Mase, Hiromu Hara, Kenichi Tomioka
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Patent number: 4855310Abstract: Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis (SRS-A).Type: GrantFiled: March 25, 1988Date of Patent: August 8, 1989Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kiyoshi Murase, Toshiyasu Mase, Hiromu Hara, Kenichi Tomioka
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Patent number: 4803211Abstract: This invention relates to novel heterocyclic compounds structurally characterized by containing a specific heterocyclic group and by the presence of --CH.sub.2 --S-- directly bound to the specific heterocyclic group. These heterocyclic compounds are useful as medicines, particularly as antagonists of SRS-A (slow reacting substance of anaphylaxis).Type: GrantFiled: July 14, 1986Date of Patent: February 7, 1989Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Toshiyasu Mase, Ryuji Tsuzuki, Hiromu Hara, Kiyoshi Murase, Kenichi Tomioka
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Patent number: 4618627Abstract: A catechol derivative represented by the formula ##STR1## The compounds of this invention are useful for the prophylaxis and treatment for various allergic diseases, ischemic heart diseases and inflammations caused by slow reacting substance of anaphylaxis (SRS-A), since the compounds inhibit very potently the formation and release of SRS-A.Type: GrantFiled: May 11, 1984Date of Patent: October 21, 1986Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kiyoshi Murase, Toshiyasu Mase, Hideki Arima, Kenichi Tomioka
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Patent number: 4497817Abstract: A novel 2-phenylimidazo[2,1-b]benzothiazole derivative shown by the following formula ##STR1## or a salt thereof which possesses an immunoregulatory action and is useful as an antiallergic agent, an antiasthmatic, and a suppressant of rejection at tissue transplantation and skin graft.Type: GrantFiled: April 26, 1983Date of Patent: February 5, 1985Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kiyoshi Murase, Toshiyasu Mase, Kenichi Tomioka
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Patent number: 4464384Abstract: Novel 2-phenylimidazo[2,1-b]benzothiazole compounds shown by general formula I ##STR1## and the salts thereof, a process of producing the compounds, and pharmaceutical compositions containing the compounds.The compounds of this invention act on immune response, in particular, suppress a delayed type hypersensitivity reaction, and are useful as antiallergic agents, antirheumatics, therapeutic agents for autoimmune diseases, and suppressants of rejection at tissue transplantation and skin graft.Type: GrantFiled: December 14, 1982Date of Patent: August 7, 1984Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kiyoshi Murase, Toshiyasu Mase, Hideki Arima, Kunihiro Niigata, Kenichi Tomioka, Shinichiro Kobayashi
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Patent number: 4457872Abstract: A novel 2-hydroxyoxanilic acid derivative shown by the following formula ##STR1## or a salt thereof. This compound possesses an immunoregulatory action and is useful as an antiallergic agent, an antiasthmatic, an antirheumatic, a carcinostatic agent, a therapeutic agent for autoimmune disease, and a suppressant of rejection at the tissue transplantation and skin graft.Type: GrantFiled: September 9, 1982Date of Patent: July 3, 1984Assignee: Yamanouchi Pharmaceutical Co.Inventors: Kiyoshi Murase, Toshiyasu Mase, Hideki Arima, Kenichi Tomioka, Yoso Numasaki
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Patent number: 4246280Abstract: There are disclosed 20-alkoxy-16-alkyl-prostadienoic acid derivatives of the formula: ##STR1## wherein A represents ##STR2## R and R.sup.5, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group, and the pharmaceutically acceptable non-toxic salts thereof. These compounds have excellent pharmacological effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.alpha..Type: GrantFiled: February 28, 1979Date of Patent: January 20, 1981Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Noriyoshi Inukai, Masuo Murakami, Hidenori Iwamoto, Isao Yanagisawa, Toshinari Tamura, Yoshio Ishii, Kenichi Tomioka, Tetsuya Shiozaki, deceased
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Patent number: 4153727Abstract: A pharmaceutical composition for rectal administration containing 11.alpha.,15(S)-dihydroxy-20-methoxy-16(S)-methyl-9-oxo-5(cis,13(trans)-pr ostadienoic acid or a water-soluble salt thereof dissolved or dispersed in a lipophilic or hydrophilic base in the presence or absence of a buffer solution or an aqueous organic amine solution.Type: GrantFiled: January 9, 1978Date of Patent: May 8, 1979Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Hidefumi Matsui, Kenichi Tomioka, Hiroitsu Kawada, Hiroo Maeno
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Patent number: 4058665Abstract: 3,15-Dilower alkyl prostaglandin E.sub.2 derivatives and 3,15-dilower alkyl prostaglandin D.sub.2 derivatives are disclosed. These compounds have antigastric ulcer activity without undesirable side effects to intestinal organs.Type: GrantFiled: November 6, 1975Date of Patent: November 15, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Noriyoshi Inukai, Masuo Murakami, Hidenori Iwamoto, Isao Yanagisawa, Toshinari Tamura, Yoshio Ishii, Tetsuya Shizaoki, Kenichi Tomioka, Tokuichi Takagi
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Patent number: 4055589Abstract: A 20-alkoxy-16-alkyl-prostadienoic acid derivative shown by the formula ##STR1## wherein A represents ##STR2## R and R.sup.5, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group,And the pharmacologically acceptable nontoxic salts thereof.The compounds have excellent effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.alpha..Type: GrantFiled: December 15, 1975Date of Patent: October 25, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Noriyoshi Inukai, Masuo Murakami, Hidenori Iwamoto, Isao Yanagisawa, Toshinari Tamura, Yoshio Ishii, Kenichi Tomioka, Tetsuya Shiozaki, deceased
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Patent number: 4026927Abstract: Novel prostaglandin derivatives are provided having the formula: ##STR1## wherein A represents ##STR2## one of R.sub.3 and R.sub.4 represents a hydrogen atom and the other of them represents a lower alkyl group; one of R.sub.5 and R.sub.6 represents a hydrogen atom and the other of them represents a hydroxyl group; and one of R.sub.7 and R.sub.8 represents a hydrogen atom and the other of them represents a lower alkyl group.The compounds of this invention have excellent effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.sub..alpha..Type: GrantFiled: September 23, 1974Date of Patent: May 31, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Noriyoshi Inukai, Hidenori Iwamoto, Toshinari Tamura, Isao Yanagisawa, Osamu Hasegawa, Yoshio Ishii, Hideya Matsuda, Tetsuya Shiozaki, Kenichi Tomioka