Patents by Inventor Kenichiro Tamaki
Kenichiro Tamaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230125992Abstract: A microneedle array unit including a microneedle array having a plurality of needle-like protrusions arranged on one surface thereof, a gripping portion provided on a side opposite to the plurality of needle-like protrusions of the microneedle array, and a container configured to accommodate the microneedle array. The container includes an accommodation portion having an opening, a deformable portion disposed on a side opposite to the opening, and a binding portion provided in the accommodation portion of the deformable portion and bound to the gripping portion of the microneedle array. The deformable portion is deformed by receiving an external force in a direction of the opening and presses the microneedle array through the gripping portion, and the microneedle array is pushed out of the accommodation portion by being pressed, and the deformable portion maintains a deformed state and presses the microneedle array.Type: ApplicationFiled: December 27, 2022Publication date: April 27, 2023Applicant: FUJIFILM CorporationInventors: Yuka KOBAYASHI, Yoshiki Sakazaki, Kenichiro Tamaki
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Microneedle array, support member, method of producing microneedle array, and microneedle array unit
Patent number: 11565099Abstract: The present invention provides a microneedle array, a support member, a method of producing a microneedle array, and a microneedle array unit which enable reduction of a drying time during production and prevention of breakage during drying. Provided are a microneedle array 120 including a sheet portion 41, a plurality of needle-like protrusions 44, and a support member 50 formed of a gripping portion 52 and a beam portion 54 having one end that is connected to the gripping portion 52, in which the sheet portion 41 is an integrally molded body which is integrally molded with the support member 50, in which at least a part of the beam portion 54 is buried under the other surface 43 of the sheet portion 41, opposite to the one surface where the needle-like protrusions 44 are provided, the gripping portion 52 is provided on the other surface 43 of the sheet portion 41, and the beam portion 54 is deformable toward a center of the sheet portion 41.Type: GrantFiled: September 14, 2020Date of Patent: January 31, 2023Assignee: FUJIFILM CorporationInventors: Yuka Kobayashi, Yoshiki Sakazaki, Kenichiro Tamaki -
Publication number: 20220324141Abstract: Provided is a method for manufacturing a microneedle array, which enables efficient and stable manufacturing of a microneedle array including a needle-shaped protrusion having a constricted shape.Type: ApplicationFiled: June 24, 2022Publication date: October 13, 2022Applicant: FUJIFILM CorporationInventors: Toshihiro Usa, Yasuhiro Sekizawa, Kenichiro Tamaki, Satoshi Chai, Kozue Ikeda
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Patent number: 11452854Abstract: Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.Type: GrantFiled: April 23, 2019Date of Patent: September 27, 2022Assignee: FUJIFILM CorporationInventors: Yoshiki Sakazaki, Ikuo Takano, Satoshi Wakamatsu, Keio Okano, Kenichiro Tamaki
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Patent number: 11197984Abstract: Provided are a microneedle array capable of improving the visibility of an appearance inspection, and a manufacturing method of the same. A microneedle array is a microneedle array including: a sheet portion having a first surface and a second surface which oppose each other; and a plurality of needle portions arranged on the first surface of the sheet portion, in which the second surface of the sheet portion is configured by a rough surface having peak portions and valley portions, and an average transmittance of the sheet portion in a wavelength range of 300 nm to 740 nm is 75% or less.Type: GrantFiled: January 31, 2020Date of Patent: December 14, 2021Assignee: FUJIFILM CorporationInventor: Kenichiro Tamaki
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Patent number: 11198234Abstract: Provided are a mold case that prevents deformation of a microneedle array, and a manufacturing method of a microneedle array. The problems are solved by the manufacturing method of a microneedle array including: a filling step of filling needle-like recessed portions of a mold having flexibility and having a plurality of the needle-like recessed portions on a front surface, with a liquid material; and a drying step of drying the liquid material in a state where the mold filled with the liquid material is stored in the mold case which causes an edge portion of the mold to be sandwiched between the lid and the pedestal.Type: GrantFiled: April 23, 2019Date of Patent: December 14, 2021Assignee: FUJIFILM CorporationInventors: Yoshiki Sakazaki, Kenichiro Tamaki, Toshihiro Usa, Ikuo Takano
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Patent number: 11160965Abstract: Provided is a method for manufacturing a transdermal absorption sheet which makes it possible to manufacture a transdermal absorption sheet with a stable shape. The method for manufacturing a transdermal absorption sheet includes a step of forming a drug layer (110) on needle-like recess portions (42) of a mold (50) having the needle-like recess portions (42), a step of supplying a polymer layer forming solution (112) to the inside of a step portion (52) of the mold (50), a step of drying the polymer layer forming solution (112) so as to form a polymer layer (114) and a transdermal absorption sheet (120), and a step of peeling off the transdermal absorption sheet (120) from the mold (50).Type: GrantFiled: March 16, 2021Date of Patent: November 2, 2021Assignee: FUJIFILM CorporationInventor: Kenichiro Tamaki
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Patent number: 11141887Abstract: Provided are a production method of a mold having a recessed pattern, and a manufacturing method of a pattern sheet having good accuracy and excellent productivity. The production method of a mold includes: a step of preparing an electroform having a protruding pattern and a mold having a first mold and a second mold forming a cavity; a step of fixing the electroform excluding an end portion of the electroform to the first mold; a clamping step of clamping the electroform excluding the end portion of the electroform and a region of the protruding pattern between the first mold and the second mold to form the cavity; and an injection step of filling the cavity with a resin.Type: GrantFiled: October 31, 2018Date of Patent: October 12, 2021Assignee: FUJIFILM CorporationInventors: Shotaro Ogawa, Toshihiro Usa, Kenichiro Tamaki
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Patent number: 11065427Abstract: Provided is a method for manufacturing a transdermal absorption sheet which suppresses the cost of manufacturing equipment and prevents deterioration of a pharmaceutical preparation or a raw material thereof, and an intermediate. A mold filled with a first polymer solution is stored in a drying container in an aseptic environment, and the first polymer solution in the mold stored in the drying container is dried outside an aseptic environment. In a case where a surface of the drying container in which the mold is stored is irradiated with an electron beam from an electron beam source, a shield that shields an electron beam is arranged at a position on a straight line connecting the electron beam source and the needle-like recessed portions.Type: GrantFiled: August 28, 2020Date of Patent: July 20, 2021Assignee: FUJIFILM CorporationInventors: Kenichiro Tamaki, Satoshi Wakamatsu
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Publication number: 20210196938Abstract: Provided is a method for manufacturing a transdermal absorption sheet which makes it possible to manufacture a transdermal absorption sheet with a stable shape. The method for manufacturing a transdermal absorption sheet includes a step of forming a drug layer (110) on needle-like recess portions (42) of a mold (50) having the needle-like recess portions (42), a step of supplying a polymer layer forming solution (112) to the inside of a step portion (52) of the mold (50), a step of drying the polymer layer forming solution (112) so as to form a polymer layer (114) and a transdermal absorption sheet (120), and a step of peeling off the transdermal absorption sheet (120) from the mold (50).Type: ApplicationFiled: March 16, 2021Publication date: July 1, 2021Applicant: FUJIFILM CorporationInventor: Kenichiro TAMAKI
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MICRONEEDLE ARRAY, SUPPORT MEMBER, METHOD OF PRODUCING MICRONEEDLE ARRAY, AND MICRONEEDLE ARRAY UNIT
Publication number: 20210085943Abstract: The present invention provides a microneedle array, a support member, a method of producing a microneedle array, and a microneedle array unit which enable reduction of a drying time during production and prevention of breakage during drying. Provided are a microneedle array 120 including a sheet portion 41, a plurality of needle-like protrusions 44, and a support member 50 formed of a gripping portion 52 and a beam portion 54 having one end that is connected to the gripping portion 52, in which the sheet portion 41 is an integrally molded body which is integrally molded with the support member 50, in which at least a part of the beam portion 54 is buried under the other surface 43 of the sheet portion 41, opposite to the one surface where the needle-like protrusions 44 are provided, the gripping portion 52 is provided on the other surface 43 of the sheet portion 41, and the beam portion 54 is deformable toward a center of the sheet portion 41.Type: ApplicationFiled: September 14, 2020Publication date: March 25, 2021Applicant: FUJIFILM CorporationInventors: Yuka KOBAYASHI, Yoshiki SAKAZAKI, Kenichiro TAMAKI -
Publication number: 20210023355Abstract: The present invention provides a method of producing a microneedle array with excellent mountability on a container and excellent handleability such as puncture or disposal, a microneedle array, and a microneedle array unit. Provided are a method of producing a microneedle array including a step of placing a support member which includes a disk portion having a through-hole and a columnar portion formed on a first surface of the disk portion, on a pattern surface of a mold having needle-like depressions, a step of supplying a base material liquid from a side of the first surface of the disk portion and filling the needle-like depressions with the base material liquid, and a drying step of drying the base material liquid to integrally mold a base material layer and the support member; the produced microneedle array; and a microneedle array unit including the microneedle array and a container.Type: ApplicationFiled: June 24, 2020Publication date: January 28, 2021Applicant: FUJIFILM CorporationInventor: Kenichiro TAMAKI
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Publication number: 20200391017Abstract: Provided is a method for manufacturing a transdermal absorption sheet which suppresses the cost of manufacturing equipment and prevents deterioration of a pharmaceutical preparation or a raw material thereof, and an intermediate. A mold filled with a first polymer solution is stored in a drying container in an aseptic environment, and the first polymer solution in the mold stored in the drying container is dried outside an aseptic environment. In a case where a surface of the drying container in which the mold is stored is irradiated with an electron beam from an electron beam source, a shield that shields an electron beam is arranged at a position on a straight line connecting the electron beam source and the needle-like recessed portions.Type: ApplicationFiled: August 28, 2020Publication date: December 17, 2020Applicant: FUJIFILM CorporationInventors: Kenichiro TAMAKI, Satoshi WAKAMATSU
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Patent number: 10814527Abstract: Provided is a method of producing a transdermal absorption sheet using an electroforming mold. A method of manufacturing an electroforming mold includes preparing a mold which is a matrix having a recessed pattern, immersing the mold in a degassed pretreatment liquid stored in a pretreatment liquid tank, then applying ultrasound waves generated from an ultrasound oscillator to the recessed pattern of the mold, and filling recessed portions constituting the recessed pattern with the pretreatment liquid. By immersing the mold in an electroforming tank and performing an electroforming treatment, an electroforming mold is manufactured. A mold having a recessed pattern is manufactured from the electroforming mold and a transdermal absorption sheet is produced using the mold.Type: GrantFiled: March 30, 2018Date of Patent: October 27, 2020Assignee: FUJIFILM CorporationInventors: Shotaro Ogawa, Kenichiro Tamaki
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Publication number: 20200246602Abstract: Provided are a microneedle array capable of improving the visibility of an appearance inspection, and a manufacturing method of the same. A microneedle array is a microneedle array including: a sheet portion having a first surface and a second surface which oppose each other; and a plurality of needle portions arranged on the first surface of the sheet portion, in which the second surface of the sheet portion is configured by a rough surface having peak portions and valley portions, and an average transmittance of the sheet portion in a wavelength range of 300 nm to 740 nm is 75% or less.Type: ApplicationFiled: January 31, 2020Publication date: August 6, 2020Applicant: FUJIFILM CorporationInventor: Kenichiro TAMAKI
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Publication number: 20190351204Abstract: Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.Type: ApplicationFiled: April 23, 2019Publication date: November 21, 2019Applicant: FUJIFILM CorporationInventors: Yoshiki SAKAZAKI, Ikuo TAKANO, Satoshi WAKAMATSU, Keio OKANO, Kenichiro TAMAKI
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Publication number: 20190351588Abstract: Provided are a mold case that prevents deformation of a microneedle array, and a manufacturing method of a microneedle array. The problems are solved by the manufacturing method of a microneedle array including: a filling step of filling needle-like recessed portions of a mold having flexibility and having a plurality of the needle-like recessed portions on a front surface, with a liquid material; and a drying step of drying the liquid material in a state where the mold filled with the liquid material is stored in the mold case which causes an edge portion of the mold to be sandwiched between the lid and the pedestal.Type: ApplicationFiled: April 23, 2019Publication date: November 21, 2019Applicant: FUJIFILM CorporationInventors: Yoshiki SAKAZAKI, Kenichiro TAMAKI, Toshihiro USA, Ikuo TAKANO
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Publication number: 20190070754Abstract: Provided are a production method of a mold having a recessed pattern, and a manufacturing method of a pattern sheet having good accuracy and excellent productivity. The production method of a mold includes: a step of preparing an electroform having a protruding pattern and a mold having a first mold and a second mold forming a cavity; a step of fixing the electroform excluding an end portion of the electroform to the first mold; a clamping step of clamping the electroform excluding the end portion of the electroform and a region of the protruding pattern between the first mold and the second mold to form the cavity; and an injection step of filling the cavity with a resin.Type: ApplicationFiled: October 31, 2018Publication date: March 7, 2019Applicant: FUJIFILM CorporationInventors: Shotaro OGAWA, Toshihiro USA, Kenichiro TAMAKI
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Publication number: 20180222088Abstract: Provided is a method of producing a transdermal absorption sheet using an electroforming mold. A method of manufacturing an electroforming mold includes preparing a mold which is a matrix having a recessed pattern, immersing the mold in a degassed pretreatment liquid stored in a pretreatment liquid tank, then applying ultrasound waves generated from an ultrasound oscillator to the recessed pattern of the mold, and filling recessed portions constituting the recessed pattern with the pretreatment liquid. By immersing the mold in an electroforming tank and performing an electroforming treatment, an electroforming mold is manufactured. A mold having a recessed pattern is manufactured from the electroforming mold and a transdermal absorption sheet is produced using the mold.Type: ApplicationFiled: March 30, 2018Publication date: August 9, 2018Applicant: FUJIFILM CorporationInventors: Shotaro OGAWA, Kenichiro TAMAKI
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Patent number: 8257868Abstract: A molten salt composition is disclosed containing two or more types of molten salt MTFSI whose anion is an imide anion TFSI and whose cation is an alkali metal M exhibits a lower electrolyte melting point and a wider operating temperature range than a simple salt does. This brings about various advantages such as a wider range of materials that are chosen for use in batteries and the like.Type: GrantFiled: March 22, 2006Date of Patent: September 4, 2012Assignee: Kyoto UniversityInventors: Rika Hagiwara, Kazuhiko Matsumoto, Kenichiro Tamaki, Toshiyuki Nohira, Takuya Goto