Abstract: The invention relates to a kinase which is activated by transforming growth factor-.beta. (TGF-.beta.) and funstions in the TGF-.beta. family signal tranduction system. The invention further relates to a process of producing said kinase and to a gene encoding said kinase.

Abstract: A method and apparatus to avoid wrong detection when detecting signals including CAS (Call Alert Signal) formed by specific frequencies in the audio range, wherein frequency components forming a specific signal are detected from an input signal, and it is judged whether any signal component other than that of specified frequency range is included or not in entered audio range signal by comparing the energy level of the entered audio range signal with the energy level of only the specified frequency components extracted from the input signal. If any signal component other than that of the specified frequency range is judged to be included as a result of the energy level comparison, the signal is judged not to be the CAS signal.

Abstract: A signal detection circuit includes band pass filters for detecting frequency components of a Call Alert signal (CAS) signal, a tone detection circuit for detecting whether or not a signal component is present in the output signals of the band pass filters, and two types of guard time setting circuits that have different guard times. When the CAS signal component is present, a transmitting speech signal is muted. Thereafter, with the guard time setting circuit having the normal guard time, it is determined whether or not the signal component lasts for a predetermined time period. Since the CAS signal is detected with two types of guard times, even if the transmitting speech signal contains a frequency component of the CAS signal, the transmitting speech signal is not mis-detected as the CAS signal.

Abstract: An improved telephone answering machine having a codec circuit 31 for converting an audio signal input/output from/to a telephone line 3 from analog to digital or digital to analog, a DSP 32 and a memory 33 for storing the supplied digital audio signal. The DSP 32 is adapted to compress data of the digital audio signal, to expand the compressed data of the digital audio signal and to correct the supplied digital audio signal so that the level of an analog audio signal after conversion from digital to analog becomes constant. When recording, the analog audio signal is recorded in the memory 33 via the codec circuit 31 and the DSP 32. When reproducing it, the audio signal recorded in the memory 33 is taken out via the DSP 32 and the codec circuit 31. Because the level of the digital audio signal is controlled in the DSP 32, the sound quality of an OGM or ICM is substantially improved in the telephone answering machine.

Abstract: Quinazoline compounds represented by general formula (1) or (2) possess an activity of significantly inhibiting the production or secretion of a tumor necrosis factor and are useful as drugs for the treatment of diseases wherein a tumor necrosis factor is considered to be involved in causing those diseases: ##STR1## wherein R.sup.1 through R.sup.

Abstract: A human monoclonal antibody, which has prophylactic and therapeutic effect to infectious diseases caused by Pseudomonas aeruginosa of serotypes A and H classified under the Japanese Committee's Classification, and the epitope of which is located at the common structure in the O-antigen of Pseudomonas aeruginosa of serotypes A and H. A hybridoma producing said human monoclonal antibody, and processes for preparing said hybridoma and antibody are also provided.

Abstract: A metal-made ornamental article, such as watch cases and the like, is provided with a bilayered coating layer composed of an undercoating layer of a specified thickness formed from an aqueous colloidal solution of sodium silicate and silica sol in a specified proportion and a top-coating layer of a specified thickness formed by coating with a solution of a partial hydrolysis-condensation product of an organic silicate ester compound, such as ethyl silicate, followed by baking to effect curing of the coating layer.

Abstract: In this invention a water pistol is eliminated the necessity of the application of strong power at the time the water is shot by utilizing the restoring power of a bowstring which is strung to a bow-shaped structure and used to push the rod. Moreover, this invention provides a means to increase the pressure on the water in a pressure compartment stably so that it is possible to stabilized the trajectory of the water forced from a nozzle of the water pistol.

Abstract: A magnetic holder has a movable body made of a material upon which a magnet can function. The movable body is attached at its center to the center of the upper surface of the magnet. The lower surface of the magnet can be attached to any surface upon which a magnet can function. The surface of the movable body which faces the magnet is divided into sections radially centering on the center point of that surface. When the movable body is caused to move so that one of its sections is attached to the magnet by magnetic force the other sections are separated from the upper surface of the magnet. Paper is held to the surface upon which the magnetic holder is placed by the clipping part on the end of the section of the movable body which is attached to the magnet.This magnetic holder allows papers to be held to and removed from the appropriate surface easily and without danger of the magnetic holder being dropped from said surface during operation.

Abstract: The invention provides a means for solving the difficult problem of the deposition of stain in the recesses to cause loss of beautiful appearance on the matted surface of an article for personal ornament made of titanium, zirconium or an alloy thereof formed by honing or barrel finishing. The method comprises the steps of (a) forming a first matted surface with microscopically fine protrusions and recesses on the article by honing or barrel finishing, (b) forming a hardened layer on the matted surface by nitriding, carbonizing, boriding or oxidizing, (c) partially removing the hardened layer covering the protrusions on the matted surface by a first electrolytic or chemical polishing, (d) forming a second matted surface on the article by honing or barrel finishing, and (e) partially removing the surface layer at the protrusions by a second electrolytic or chemical polishing to smoothen the surface leaving a sandy appearance.

Abstract: The polyhedral body of aluminum such as a watch case obtained by the inventive method is colored in two different colors on different polyhedral faces demarcated by the ridgeline therebetween with remarkable decisiveness not obtained in the prior art methods. The inventive method utilizes anodization and coloring by dyeing in two steps. A part of the polyhedral faces anodized and colored in a dark color in the first step is ground to expose the bare surface of aluminum, which is then activated by dipping in an aqueous acid solution and again anodized by applying an unconventionally high voltage in an electrolyte bath of a specific composition followed by coloring in a light color decoratively distinguishable from the dark color imparted in the first step coloring.

Abstract: The polyhedral body of aluminum such as a watch case obtained by the inventive method is colored in two different colors on different polyhedral faces demarcated by the ridgeline therebetween with remarkable decisiveness not obtained in the prior art methods. The inventive method utilizes anodization and coloring by dyeing in two steps. A part of the polyhedral faces anodized and colored in a dark color in the first step is ground to expose the bare surface of aluminum, which is then activated by dipping in an aqueous acid solution and again anodized by applying an unconventionally high voltage in an electrolyte bath of a specific composition followed by coloring in a light color decoratively distinguishable from the dark color imparted in the first step coloring.

Abstract: A cephalosporin derivative of the formula (I), ##STR1## wherein A is a mono- or polycyclic heteroaromatic ring, which contains at least one nitrogen atom as a hetero atom and which may be substituted with one or more substituents; R is a phenyl group substituted with at least one substituent selected from the group consisting of an amino group, a hydroxy group, a ureido group and a hydroxymethyl group; and X is an --OCOCH.sub.

Abstract: A cephalosporin derivative of the formula (I), ##STR1## wherein A is a mono- or polycyclic heteroaromatic ring, which contains at least one nitrogen atom as a hetero atom and which may be substituted with one or more substituents; R is a phenyl group substituted with at least one substituent selected from the group consisting of an amino group, a hydroxy group, a ureido group and a hydroxymethyl group; and X is an --OCOCH.sub.

Abstract: A cephalosporin derivative of formula (I): ##STR1## wherein X is an --OCOCH.sub.3 group or an --S--Het group in which Het is a 5- or 6-membered heterocyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms, which may be substituted with one or more substituents, and the non-toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial material and which are prepared by the reaction of a compound of formula (II): ##STR2## or a reactive derivative thereof, with a compound of formula (III): ##STR3## wherein X is as defined above, or a derivative thereof.

Abstract: A cephalosporin derivative of formula (I): ##STR1## wherein X is an --OCOCH.sub.3 group or an -S-Het group in which Het is a 5- or 6-membered heterocyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms, which may be substituted with one or more substituents, and the non-toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial material and which are prepared by the reaction of a compound of formula (II): ##STR2## or a reactive derivative thereof, with a compound of formula (III): ##STR3## wherein X is as defined above, or a derivative thereof.

Abstract: A penicillin of the formula: ##STR1## (i.e. 6-[D-2-(3-hydroxypyridazine-4-carbonamido)-2-(p-hydroxyphenyl)acetamido]pe nicillanic acid), which is valuable as an antibacterial agent, a nutritional supplement in animal feeds and a therapeutic agent in poultry and mammals including man and is especially useful in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.