Abstract: 1,2,3 Triazines according to formula (I): and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering.

Abstract: The present invention relates to nitrogen-containing heterocyclic compounds represented by formula (I): wherein W represents 1,4-piperazinediyl, etc.; U represents NR1R2 (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, etc.; and R2 represents a hydrogen atom, etc. ), OR4, or SR5; V represents an oxygen atom, a sulfur atom, N—R6, or CR7R8, at least one of X, Y and Z represents a nitrogen atom, and the others are the same or different, and each represents a nitrogen atom or C—RA; and D1, D2, D3 and D4 each independently represent C—RB, a nitrogen atom, an oxygen atom, a sulfur atom, etc., optional adjoining two among D1 to D4 are combined to represent a nitrogen atom, N—R2A, an oxygen atom, a sulfur atom, etc.

Abstract: The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of PDGF receptor to hinder abnormal cell growth and cell wandering and thus are useful for the prevention or treatment of cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

Abstract: 1,3 Diazines according to formula (I): and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering. The compounds may be used to treat or prevent cell-proliferative disorders such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

Abstract: 1,3 Diazines and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering. The compounds may be used to treat or prevent cell-proliferative disorders such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

Abstract: The present invention is directed to methods for the expansion of non-terminally differentiated cells ("precursor cells") using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.

Abstract: A container obtained by biaxially stretch-blow-molding a resin. Except the mouth-and-neck portion, vicinities thereof and the center of the bottom portion, the container as a whole is reduced in thickness under a highly drawing condition without accompanied by whitening, and a portion constituting the bottom valley portions has an yielding load of not smaller than 25 kg/cm at 70.degree. C. The container exhibits excellent heat resistance, pressure resistance, shock resistance as well as self-standing ability.

Abstract: A container is obtained by biaxially stretch-blow-molding a resin. Except the mouth-and-neck portion, vicinities thereof and the center of the bottom portion, the container as a whole is reduced in thickness under a highly drawing condition without being accompanied by whitening, and a portion constituting the bottom valley portions has an yielding load of not smaller than 25 kg/cm at 70.degree. C. The container exhibits excellent heat resistance, pressure resistance, shock resistance as well as self-standing ability.

Abstract: The present invention is directed to methods for the expansion of non-terminally differentiated cells ("precursor cells") using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.

Abstract: The present invention relates to amino acid sequences of the encoded deltex protein. The invention further relates to fragments and other derivatives, and analogs, of deltex proteins. In specific embodiments, the invention relates to deltex protein derivatives and analogs of the invention which are functionally active, or which comprise one or more domains of a deltex protein, including but not limited to the Gln-rich clusters, SH3 binding domains, domains which mediate binding to Notch or to a Notch derivative containing Notch cdc10/SW16/ankyrin ("ANK") repeats, domains which mediate binding to a second deltex protein, or any combination of the foregoing. The present invention also relates to compositions based on deltex proteins.

Abstract: In a biaxially-stretch-blow-molded container there is a method of producing the same. Redraw ratio at the bottom portion is small in the secondary blow molding without employing a complex heating system but in which a secondary article obtained by subjecting a preform article to the primary blow molding is preferentially shrunk at its bottom portion, and a tertiary article or a quaternally article before being subjected to the secondary blow molding is obtained having a bottom of a flat shape or in which the central portion is recessed inwardly of the container and the periphery thereof is flattened. The bottle obtained by this method has a thickness and crystallinity in the bottom portion which are nearly the same as those of the center of the barrel and are highly oriented. The heat-resistant bottle exhibits excellent strength in the bottom portion and symmetrical panel-sinking stability in the vacuum pressure.

Abstract: The present invention relates to imidazoquinazoline derivatives represented by the general formula (I): ##STR1## or pharmacologically acceptable salts thereof. The compounds of the present invention have strong and selective cGMP-specific PDE inhibitory activity and are useful for treating or ameliorating cardiovascular diseases such as thrombosis, angina pectoris, hypertension, arterial sclerosis and the like, as well as asthma and the like.

Abstract: A process for producing biaxially drawn plastic bottles having excellent heat resistance and an apparatus therefor. The process comprises a step of biaxially drawing and free blow-molding the preformed article to obtain a secondary molded article thereof, a step of heating the secondary molded article by inserting it for 0.3 to 5 seconds in the infrared rays emitted from an infrared-ray radiation member that has a substantially planar radiation surface having a height larger than that of the secondary molded article in the direction of height and having a surface temperature of from 350.degree. C. to 1000.degree. C., in order to obtain a tertiary product thereof that is shrunk, and a step for blow-molding the tertiary product that is in a heated state in a metal mold to obtain a final molded article. A single metal mold is used for blow-molding to shorten the time occupied by the metal mold and to produce the bottles having excellent heat resistance maintaining high productivity.

Abstract: A biaxially-stretch-blow-molded container and a method of producing the same. Redraw ratio at the bottom portion is small in the secondary blow molding without employing a complex heating system but in which a secondary article obtained by subjecting a preform article to the primary blow molding is preferentially shrunk at its bottom portion, and a tertiary article or a quaternally article before being subjected to the secondary blow molding is obtained having a bottom of a flat shape or in which the central portion is recessed inwardly of the container and the periphery thereof is flattened. The bottle obtained by this method has a thickness and crystallinity in the bottom portion which are nearly the same as those of the center of the barrel and are highly oriented. The heat-resistant bottle exhibits excellent strength in the bottom portion and symmetrical panel-sinking stability in the vacuum pressure.

Abstract: Two thin plate members preferably made of metallic sheets are prepared and one end surface of at least one of the members is formed so as to have an inwardly curved recess which constitutes a gap when the end surfaces of the members are linearly butted together. A laser beam is irradiated along the butted portion of the members. The gap may have various forms having a predetermined width. The two members to be butt-welded may be substituted by two end portions of a single metallic sheet having a rectangular configuration in the case where a shell portion of a can is formed by the butt-welding operation.

Abstract: A process for manufacturing the butt-welded cans comprises the steps of applying a 0.5 to 3.5 .mu.m thick organic resin film for preventing the adhesion of melted metal particles to at least a 1-mm-wide region from the butt-weld portion edge of at least the inner surface of a steel plate can blank, and butt-welding the edges of the can blank by the use of a laser, or alternatively applying a 0.5 to 7.0.mu.m thick organic resin film, butting the edges of the can blank, and laser-welding the butted edges while a cooling device is brought into contact with the butted edges from the inner side of each can. In this case, it is preferred that the coating material having high thermal decomposition resistance is applied to the whole outer surface of each can, and the weld portion is then butt-welded by means of a CO.sub.2 laser.

Abstract: There is here provided butt-welded cans made of steel plates having a carbon concentration of 0.02 to 0.09% by weight, the aforesaid butt-welded cans being characterized in that a coating film for preventing the adhesion of melted metal particles is applied to at least the inner surface of the weld portion and its vicinity of each can, and a carbon concentration index I of the weld portion satisfies the formula (1)I=(Iw/Ic).times.10.sup.3 .ltoreq.15 (1)wherein Iw is a K.alpha. X ray intensity, of carbon in the weld portion, measured by the EPMA method, andIc is a K.alpha. X ray intensity, of carbon in graphite, measured by the EPMA method.

Abstract: A method and apparatus for guiding the opposed edges of sheet material into substantially abutting edge-to-edge relationship with one another and thereafter welding said edges by a high energy welding source to form a seam. The invention enables the continuous high speed butt welding of the sheet material to form cylindrical bodies. The apparatus includes three elements, a mandrel, a mandrel holder and tube holders. Sheet material is fed to around said mandrel and advanced by a tube holder with an edge of two opposite edges of said sheet material being in intimate contact with a basis plane of said mandrel holder. Another edges is slided into contact with above mentioned edge of sheet material making abutting relationship after passing through the basis plane of said mandrel holder. These abutting edges pass a high energy zone of a welder and butt welded to make a tube.

Abstract: Disclosed is a welded can having at least the inner face side of a weld seam covered with a composite film of a thermoplastic resin, wherein the thermoplastic resin composite film comprises (I) an innermost layer, located on the inner face side of the can, of a thermoplastic polyester having a molecularly oriented crystal and comprising a dibasic acid component content of at least 90 mole % of terephthalic acid and a diol component containing at least 90 mole % of ethylene glycol, said innermost layer (I) overlayer (II) a seam-contacting layer, located on the seam side, of a thermoplastic copolyester containing in the chain molecule a dibasic acid component containing 40 to 95 mole % of terephthalic acid and 0 to 40 mole % of isophthalic acid and a diol component containing ethylene glycol and butane diol in a total amount of 65 to 100 mole % at a molar ratio of from 5/95 and 80/20 or a blend of such copolyesters, and the composite film comprising the layers (I) and (II) has an elasticity modulus of 5 to 220

Abstract: A can body of surface treated steel plate, such as TFS, having adjacent longitudinally extending edges of tubular shaped member welded by irradiation of laser beam and provided with inside surface of welded seam having reliable paint retaining characteristic and free from projections, such as upset. For the purpose, welding is carried out such that inside and outside width of molten-solidified zone and structure changed zone will be maintained within a predetermined range and that metallic wire or elongated backing strip is located oppositely to lower surface of both edges being butt-welded.