Patents by Inventor Kenjiro Hanaoka
Kenjiro Hanaoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11560365Abstract: A novel non-fluorescent rhodamine dye forms a twisted intramolecular charge transfer state. A substituent that causes steric hindrance is introduced at an ortho position of a dimethylamino group on the xanthene ring of tetramethylrhodamine, which is a general rhodamine that exhibits strong fluorescence, and a certain amount of twist is imparted in a ground state. As a result, the formation of the twisted intramolecular charge transfer state is promoted in the excited state and non-fluorescence is exhibited.Type: GrantFiled: March 4, 2019Date of Patent: January 24, 2023Assignee: THE UNIVERSITY OF TOKYOInventors: Kenjiro Hanaoka, Yasuteru Urano, Takayuki Ikeno
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Publication number: 20210087160Abstract: A novel non-fluorescent rhodamine dye forms a twisted intramolecular charge transfer state. A substituent that causes steric hindrance is introduced at an ortho position of a dimethylamino group on the xanthene ring of tetramethylrhodamine, which is a general rhodamine that exhibits strong fluorescence, and a certain amount of twist is imparted in a ground state. As a result, the formation of the twisted intramolecular charge transfer state is promoted in the excited state and non-fluorescence is exhibited.Type: ApplicationFiled: March 4, 2019Publication date: March 25, 2021Inventors: Kenjiro HANAOKA, Yasuteru URANO, Takayuki IKENO
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Patent number: 10815379Abstract: Fluorescent probes and their salts have high fluorescence quantum yield and high resistance to photobleaching suitable for visualizing various pH environments within cells such as weakly basic, neutral, and weakly acidic environments.Type: GrantFiled: January 15, 2016Date of Patent: October 27, 2020Assignee: THE UNIVERSITY OF TOKYOInventors: Kenjiro Hanaoka, Yu Kagami, Tetsuo Nagano, Yasuteru Urano
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Publication number: 20200087326Abstract: A near-infrared fluorescent probe has fluorescence in the near-infrared region. Like CaSiR-1, the probe has rhodamines as the fluorescent mother nucleus and accumulates in the cytoplasm. The probe makes it possible to visualize concentration fluctuations in metal ions, such as calcium ions, within the body.Type: ApplicationFiled: December 1, 2017Publication date: March 19, 2020Inventors: Kenjiro HANAOKA, Yasuteru URANO, Koji NUMASAWA, Takayuki IKENO, Yuki HOSHINO
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Patent number: 10004815Abstract: [Problem] To provide a novel near-infrared quencher. [Solution] A compound represented by general formula (I) or a salt thereof.Type: GrantFiled: December 4, 2014Date of Patent: June 26, 2018Assignee: THE UNIVERSITY OF TOKYOInventors: Kenjiro Hanaoka, Takuya Myochin, Tetsuo Nagano, Yasuteru Urano
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Publication number: 20180118943Abstract: Fluorescent probes and their salts have high fluorescence quantum yield and high resistance to photobleaching suitable for visualizing various pH environments within cells such as weakly basic, neutral, and weakly acidic environments.Type: ApplicationFiled: January 15, 2016Publication date: May 3, 2018Inventors: Kenjiro HANAOKA, Yu KAGAMI, Tetsuo NAGANO, Yasuteru URANO
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Publication number: 20180052105Abstract: Fluorescent probes and their salts show sufficient solubility in water and detect sulfane sulfur in vivo.Type: ApplicationFiled: January 21, 2016Publication date: February 22, 2018Inventors: Kenjiro HANAOKA, Kazuhito SHIMAMOTO, Yasuteru URANO, Yoko TAKANO
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Patent number: 9714260Abstract: [Problem] To provide: a compound resulting from substituting with a silicon atom the oxygen atom at position 10 of a xanthene ring site of a rhodamine of which amino groups at position 3 and position 6 have an asymmetrical structure; a method for producing the compound; and a fluorescent probe that uses the compound. [Solution] The compound represented by general formula (I) or a salt thereof.Type: GrantFiled: January 7, 2014Date of Patent: July 25, 2017Assignee: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Kenjiro Hanaoka, Takahiro Egawa, Yu Kushida, Koji Numasawa, Takuya Myochin, Wen Piao
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Patent number: 9688857Abstract: A compound represented by the formula (I) (R1 represents hydrogen atom or a monovalent substituent; R2 and R3 represent hydrogen atom, an alkyl group, or a halogen atom; R4 and R5 represent an alkyl group or an aryl group; R6 and R7 represent hydrogen atom, an alkyl group, or a halogen atom; R8 represent hydroxy group or a dialkoxyboranetriyl group; and X represents silicon atom, germanium atom, or tin atom), which is a novel fluorophore usable as a mother nucleus of an off/on type fluorescent probe not utilizing the intramolecular photoinduced electron transfer.Type: GrantFiled: October 13, 2016Date of Patent: June 27, 2017Assignee: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Kenjiro Hanaoka, Yuichiro Koide, Takahiro Egawa, Kazuhisa Hirabayashi
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Publication number: 20170096561Abstract: A compound represented by the formula (I) (R1 represents hydrogen atom or a monovalent substituent; R2 and R3 represent hydrogen atom, an alkyl group, or a halogen atom; R4 and R5 represent an alkyl group or an aryl group; R6 and R7 represent hydrogen atom, an alkyl group, or a halogen atom; R8 represent hydroxy group or a dialkoxyboranetriyl group; and X represents silicon atom, germanium atom, or tin atom), which is a novel fluorophore usable as a mother nucleus of an off/on type fluorescent probe not utilizing the intramolecular photoinduced electron transfer.Type: ApplicationFiled: October 13, 2016Publication date: April 6, 2017Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo NAGANO, Kenjiro HANAOKA, Yuichiro KOIDE, Takahiro EGAWA, Kazuhisa HIRABAYASHI
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Publication number: 20160368895Abstract: [Problem] The present invention addresses the problem of providing a compound that is useful for preventing or treating diseases associated with malfunctioning of PGI2 receptors, in particular, pulmonary hypertension. [Solution] A positive allosteric regulator of a PGI2 receptor which comprises a compound represented by formula (1) or a pharmaceutically acceptable salt, hydrate or solvate thereof. (1) (In the formula, R1 is a branched chain or cyclic alkyl or alkenyl having 3 to 10 carbon atoms which may be substituted, R2 is a hydrogen atom or an alkyl having 1 to 6 carbon atoms which may be substituted, R3 is 1 to 4 substituents which are the same or different independently selected from the group consisting of a hydrogen atom, a halogen atom, an alkyl having 1 to 6 carbon atoms which may be substituted, and an alkoxy having 1 to 6 carbon atoms which may be substituted, and A is an aryl which may be substituted or a heteroaryl which may be substituted.Type: ApplicationFiled: November 27, 2014Publication date: December 22, 2016Applicants: THE UNIVERSITY OF TOKYO, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITYInventors: Tetsuo NAGANO, Takayoshi OKABE, Hirotatsu KOJIMA, Toshifumi SUZUKI, Kenjiro HANAOKA, Manabu SHIMONISHI, Shinichiro EGASHIRA, Hirofumi NAKANO, Kazuo KUMAGAI, Hiroyuki MIYACHI, Kenji MATSUNO, Minoru WAKI
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Publication number: 20160296639Abstract: [Problem] To provide a novel near-infrared quencher. [Solution] A compound represented by general formula (I) or a salt thereof.Type: ApplicationFiled: December 4, 2014Publication date: October 13, 2016Applicant: THE UNIVERSITY OF TOKYOInventors: Kenjiro HANAOKA, Takuya MYOCHIN, Tetsuo NAGANO, Yasuteru URANO
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Patent number: 9329184Abstract: A compound represented by the formula (I) (R1 represents a substituent on the benzene ring; R2 represents a monovalent substituent; R3 and R4 represent hydrogen atom, or an alkyl group; R5 and R6 represent an alkyl group, or an aryl group; R7 and R8 represent hydrogen atom, or an alkyl group; R9 and R10 represent hydrogen atom, or a monovalent substituent; and X represents silicon atom, germanium atom, or tin atom), or a salt thereof.Type: GrantFiled: February 17, 2012Date of Patent: May 3, 2016Assignee: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Kenjiro Hanaoka, Yuichiro Koide, Takahiro Egawa, Yu Kushida
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Publication number: 20160102336Abstract: [Problem] To provide a novel fluorescent probe for detecting the activity of calpain. [Solution] A compound represented by general formula (I) or a salt thereof.Type: ApplicationFiled: March 4, 2014Publication date: April 14, 2016Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo NAGANO, Kenjiro HANAOKA, Yu KUSHIDA
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Publication number: 20160047748Abstract: [Problem] To provide a fluorescent probe having a novel fluorophore. [Solution] A compound represented by general formula (I), or a salt thereof.Type: ApplicationFiled: March 4, 2014Publication date: February 18, 2016Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo NAGANO, Kenjiro HANAOKA, Kazuhisa HIRABAYASHI
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Patent number: 9250232Abstract: A compound represented by the formula (I) [R1 represents hydrogen atom or a substituent; R2, R3, R6, and R7 represent hydrogen atom, an alkyl group, a halogen atom, or a hydrophilic substituent; R4 and R5 represent an alkyl group or an aryl group; R8 and R9 represent a group cleaved by contact with an object substance for measurement; and X represents silicon atom, germanium atom, or tin atom] or a salt thereof, which is useful as a fluorescent probe that emits red fluorescence by contact with an object substance for measurement.Type: GrantFiled: February 15, 2013Date of Patent: February 2, 2016Assignee: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Kenjiro Hanaoka, Kazuhisa Hirabayashi, Yuko Toki
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Publication number: 20160023988Abstract: A compound represented by the formula (I) (R1 represents hydrogen atom or a monovalent substituent; R2 and R3 represent hydrogen atom, an alkyl group, or a halogen atom; R4 and R5 represent an alkyl group or an aryl group; R6 and R7 represent hydrogen atom, an alkyl group, or a halogen atom; R8 represent hydroxy group or a dialkoxyboranetriyl group; and X represents silicon atom, germanium atom, or tin atom), which is a novel fluorophore usable as a mother nucleus of an off/on type fluorescent probe not utilizing the intramolecular photoinduced electron transfer.Type: ApplicationFiled: September 15, 2015Publication date: January 28, 2016Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo NAGANO, Kenjiro HANAOKA, Yuichiro KOIDE, Takahiro EGAWA, Kazuhisa HIRABAYASHI
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Publication number: 20150353585Abstract: [Problem] To provide: a compound resulting from substituting with a silicon atom the oxygen atom at position 10 of a xanthene ring site of a rhodamine of which amino groups at position 3 and position 6 have an asymmetrical structure; a method for producing the compound; and a fluorescent probe that uses the compound. [Solution] The compound represented by general formula (I) or a salt thereof.Type: ApplicationFiled: January 7, 2014Publication date: December 10, 2015Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo NAGANO, Kenjiro HANAOKA, Takahiro EGAWA, Yu KUSHIDA, Koji NUMASAWA, Takuya MYOCHIN, Wen PIAO
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Patent number: 9187499Abstract: A compound represented by the formula (I) (R1 represents hydrogen atom or a monovalent substituent; R2 and R3 represent hydrogen atom, an alkyl group, or a halogen atom; R4 and R5 represent an alkyl group or an aryl group; R6 and R7 represent hydrogen atom, an alkyl group, or a halogen atom; R8 represent hydroxy group or a dialkoxyboranetriyl group; and X represents silicon atom, germanium atom, or tin atom), which is a novel fluorophore usable as a mother nucleus of an off/on type fluorescent probe not utilizing the intramolecular photoinduced electron transfer.Type: GrantFiled: January 19, 2012Date of Patent: November 17, 2015Assignee: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Kenjiro Hanaoka, Yuichiro Koide, Takahiro Egawa, Kazuhisa Hirabayashi
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Patent number: 9170266Abstract: A compound represented by the formula (I) (one of substituents represented by R1 is a trapping group for an object substance for measurement; R2 and R3 represent hydrogen, alkyl, or halogen; R4 and R5 represent alkyl or aryl; R6 and R7 represent hydrogen, alkyl, or halogen; R8 represents hydrogen, alkylcarbonyl, or alkylcarbonyloxymethyl, and X represents silicon, germanium, or tin, which can be used as a fluorescent probe that enables red color bioimaging using intramolecular photoinduced electron transfer.Type: GrantFiled: February 17, 2012Date of Patent: October 27, 2015Assignee: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Kenjiro Hanaoka, Yuichiro Koide, Takahiro Egawa