Patents by Inventor Kenneth A. Watts
Kenneth A. Watts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11981892Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.Type: GrantFiled: April 15, 2019Date of Patent: May 14, 2024Assignee: UNIVERSITY OF MASSACHUSETTSInventors: Craig Cameron Mello, Krishna Sumanth Ghanta, Gregoriy Dokshin, Aamir Mir, Hassan Gneid, Jonathan Kenneth Watts, Erik Joseph Sontheimer
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Patent number: 11976487Abstract: Elements of drop-stitch material are formed into different structures. In a platform, two legs support a horizontal platform. All are of drop-stitch material, which can be inflated to sufficient pressure for it to be rigid. Valves between the legs and platform allow air to flow between the legs and the platform. Another design is a luggage or cargo carrier for vehicles with a base, top and front walls formed of interconnected drop-stitch material. When the drop-stitch material is inflated, the material forms a cavity which receives luggage or other items. Sidewalls create an enclosed space. elements of the drop-stitch material can form other structures such as a truck shell with openings through the material to acts as windows or a door.Type: GrantFiled: September 22, 2021Date of Patent: May 7, 2024Assignee: FLATED LLCInventors: Daniel Watts, Kenneth Tenhoeve, Ryan Guay
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Publication number: 20240124870Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.Type: ApplicationFiled: June 9, 2023Publication date: April 18, 2024Inventors: Craig Cameron Mello, Krishna Sumanth Ghanta, Gregoriy Dokshin, Aamir Mir, Hassan Gneid, Jonathan Kenneth Watts, Erik Joseph Sontheimer
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Publication number: 20230407295Abstract: Protecting oligonucleotides are provided. Protecting oligonucleotides with 5? and/or 3? conjugated moieties are provided. Protecting oligonucleotides with chemical modifications are provided. Methods of using the protecting oligonucleotides for genome editing with a CRISPR nuclease and kits for performing the same are also provided.Type: ApplicationFiled: April 28, 2023Publication date: December 21, 2023Inventors: Han Zhang, Erik Joseph Sontheimer, Jonathan Kenneth Watts, Anastasia Khvorova
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Publication number: 20230183687Abstract: Chemically modified Neisseria meningitidis (Nme) crRNAs, tracrRNAs, and sgRNAs are provided. Methods of using the Nme crRNAs, tracrRNAs, and sgRNAs for genome editing with a Nme CRISPR nuclease and kits for performing the same are also provided.Type: ApplicationFiled: October 12, 2022Publication date: June 15, 2023Inventors: Erik Joseph Sontheimer, Jonathan Kenneth Watts, Anastasia Khvorova, Nathan Bamidele
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Publication number: 20210388348Abstract: Chemically modified crRNAs and tracrRNAs are provided. crRNAs and tracrRNAs with 5? and/or 3? conjugated moieties are provided. crRNAs and tracrRNAs with modifications in the repeat region of the crRNA or the anti-repeat region of the tracrRNA are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided.Type: ApplicationFiled: May 12, 2021Publication date: December 16, 2021Inventors: Erik Joseph Sontheimer, Anastasia Khvorova, Jonathan Kenneth Watts, Nadia Amrani, Zexiang Chen, Matthew Hassler, Dimas Echeverria Moreno, Julia Frances Alterman, Scot Wolfe, Ken Yamada, Gitali Devi, Han Zhang
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Publication number: 20210363518Abstract: Chemically modified crRNAs and tracrRNAs are provided. crRNAs and tracrRNAs with 5? and/or 3? conjugated moieties are provided. crRNAs and tracrRNAs with modifications in the repeat region of the crRNA or the anti-repeat region of the tracrRNA are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided.Type: ApplicationFiled: March 18, 2019Publication date: November 25, 2021Inventors: Erik Joseph SONTHEIMER, Anastasia KHVOROVA, Jonathan Kenneth WATTS, Aamir MIR, Julia Frances ALTERMAN, Matthew Ryan HASSLER, Michael Harry BRODSKY, Alexandre Jean-Marie DEBACKER
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Publication number: 20190345479Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.Type: ApplicationFiled: April 15, 2019Publication date: November 14, 2019Inventors: Craig Cameron Mello, Krishna Sumanth Ghanta, Gregoriy Dokshin, Aamir Mir, Hassan Gneid, Jonathan Kenneth Watts, Erik Joseph Sontheimer
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Publication number: 20090099046Abstract: Drilling fluids, drilling fluid additives and methods for oil well drilling feature quaternary ammonium salts and act to reduce accretion of bituminous material on metal surfaces of drilling equipment.Type: ApplicationFiled: September 15, 2008Publication date: April 16, 2009Inventors: Danny E. Procter, Kenneth Watts
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Publication number: 20060261108Abstract: A wearable sports wallet comprises a lightweight washable band which may be worn around a wrist or ankle during recreational and athletic activities. The band comprises a compartment for receiving and storing small personal items therein and closure means for securing items within the compartment.Type: ApplicationFiled: July 21, 2005Publication date: November 23, 2006Inventor: Kenneth Watts
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Patent number: 6279964Abstract: A removable connector for use between angled, immovable high pressure lines is disclosed. One embodiment of the connector utilizes a tubular elbow portion having a mating flange on each end and an adapter which mates with one of the elbow flanges. The remaining elbow flange mates with a flange at the end of one of the high pressure lines and the free end of the adapter mates with a flange at the end of the other high pressure line. The mating flange surfaces are frusto-conical in shape and corresponding frusto-conical seal rings are placed between the mating surfaces. The elbow and adapter are adapted to have their respective ends placed at the pipe flanges and their bodies rotated toward each other until their opposite ends mate with each other. The flanges are then bolted together and tightened to ensure sealing engagement and bring the elbow and adapter into alignment with the pipes.Type: GrantFiled: December 15, 1997Date of Patent: August 28, 2001Assignee: Specialty Piping Components, Inc.Inventor: Kenneth A. Watts
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Patent number: 6252413Abstract: A method and apparatus for testing through the connector of a circuit card. The apparatus includes a block, which may be tapered, to offset the force applied when engaging the connector. The block is adjustably mounted to accommodate testing of different-sized circuit cards.Type: GrantFiled: December 2, 1999Date of Patent: June 26, 2001Assignee: International Business Machines CorporationInventor: Rondell Kenneth Watts
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Patent number: 6051983Abstract: A method and apparatus for testing through the connector of a circuit card. The apparatus includes a block, which may be tapered, to offset the force applied when engaging the connector. The block is adjustably mounted to accommodate testing of different-sized circuit cards.Type: GrantFiled: November 3, 1997Date of Patent: April 18, 2000Assignee: International Business Machines CorporationInventor: Rondell Kenneth Watts
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Patent number: 5845386Abstract: A removable connector for use between angled, immovable high pressure lines is disclosed. The connector utilizes a tubular elbow portion having a mating flange on each end and an adapter which mates with one of the elbow flanges. The remaining elbow flange mates with a flange at the end of one of the high pressure lines and the free end of the adapter mates with a flange at the end of the other high pressure line. The mating flange surfaces are frusto-conical in shape and corresponding frusto-conical seal rings are placed between the mating surfaces. The elbow and adapter are adapted to have their respective ends placed at the pipe flanges and their bodies rotated toward each other until their opposite ends mate with each other. The flanges are then bolted together and tightened to ensure sealing engagement and bring the elbow and adapter into alignment with the pipes.Type: GrantFiled: August 30, 1996Date of Patent: December 8, 1998Assignee: Taper-Lok CorporationInventor: Kenneth A. Watts
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Patent number: 5791934Abstract: A tester having as an interconnect structure a pair of resilient, elastomeric, vise-like interconnect grips having conductive tracings thereon. This interconnect structure provides electrical conduction between the conductive tabs of an adapter card under test and the tester.Type: GrantFiled: May 31, 1996Date of Patent: August 11, 1998Assignee: International Business Machines CorporationInventors: Jeffrey Alan Hatley, Jerry Thomas Paradise, David Timothy Zimmerman, Rondell Kenneth Watts
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Patent number: 5120309Abstract: The protective shield for a hypodermic syringe includes a tubular body which overlies the needle of the syringe when the shield is in the forward position. The protective shield has an opening therein to permit exposure of the needle when the shield is in the retracted position. A detent engages the syringe and the shield to limit relative motion therebetween and to releasably lock the shield in its end positions.Type: GrantFiled: June 9, 1989Date of Patent: June 9, 1992Inventor: Kenneth A. Watts
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Patent number: 4002852Abstract: An electronic telephone network suitable for use with a two-wire telephone line includes a low-output dynamic microphone coupled to a preamplifier. The output signal of the preamplifier is coupled through a first equalization network which is responsive to an equalization signal which is related to the DC line current to equalize the frequency and amplitude spectrum of the transmitted signal irrespective of the telephone line length or loss. The output of the equalization network is applied to a line-driver amplifier, and as a first input to an electronic signal separator or hybrid. The output of the line-driver is coupled to the two-wire line, and as a second input through the separator by way of an attenuator. The output of the separator is coupled to a receive amplifier by way of a second equalization network which is also responsive to the equalization signal to equalize the frequency spectrum of the receive signal as a function of line length.Type: GrantFiled: July 8, 1975Date of Patent: January 11, 1977Assignee: International Telephone and Telegraph CorporationInventor: Kenneth Watt Martin