Abstract: A pharmaceutical composition is disclosed, including: an interleukin-1 receptor antagonist, wherein the interleukin-1 receptor antagonist is a protein or a peptide; a buffer; and optionally one or more additional components each selected from the group consisting of a stabilizer and a tonicity modifier, wherein the pharmaceutical composition is adapted for administration via inhalation. Kits including the pharmaceutical composition of same and method of using same for treating an inflammatory disorder of lower airways in a human subject are also disclosed.

Abstract: A video poker system and method allow a player to play a primary game in a conventional fashion while seeking a bonus payout based on cards from the primary game poker hand and one or more secondary poker hands from separate decks of cards. Certain pre-established poker hands (e.g., 4s of a kind) formed using cards from the primary game poker hand and the one or more secondary poker hands provide bonus payouts. A bonus hand may comprise a royal flush hand made using one royal flush card from each of five secondary poker hands. The system and method increase player interest, player wagers and provide meaningful bonus payouts.

Abstract: Certain embodiments of the present invention relate to methods and products for use in the determination of treatment of rheumatoid arthritis (RA). Particularly, although not exclusively, embodiments of the present invention relate to predicting the likelihood of a patient suffering from rheumatoid arthritis maintaining remission following cessation of disease-modifying anti-rheumatic drugs (DMARDs). Certain embodiments of the present invention are based on the determination of certain biomarkers of drug-free remission in RA following cessation of DMARD therapy.

Abstract: Deep brain stimulation (DBS) can be used to treat many neurological conditions beyond traditional movement disorders. When patients do not suffer from traditional movement disorders, medical professionals cannot use traditional observation-based methods to configure the DBS system. A new method for selecting stimulation configurations can include recording internal data and external data as the patient performs (or attempts to perform) a motor task. The internal data is electrophysiology data recorded by a plurality of DBS electrodes, used to identify at least one of the plurality of electrodes closest to a neuronal population involved in control of the at least one motor task. The external data is electroencephalogram (EEG) data recorded by scalp electrodes, which is used to select at least one of the potential stimulation electrodes to deliver the DBS. When the electrode(s) delivering the DBS are selected, optimal parameters for the DBS are then chosen.

Abstract: A wagering game method includes dealing an initial poker hand, forming a final poker hand (optionally by discarding and replacing zero or more playing cards from the initial poker hand), and forming an augmented final poker hand by dealing additional cards to the final poker hand. Optionally, multiple augmented final poker hands may be formed from a single final poker hand by dealing additional cards from different decks to the same final poker hand. The augmented final poker hands are evaluated and a reward is issued based on the payout, if any, associated with the poker rank of each augmented final poker hand.

Abstract: A wagering game method includes dealing an initial poker hand, forming a final poker hand (optionally by discarding and replacing zero or more playing cards from the initial poker hand), and forming an augmented final poker hand by dealing additional cards to the final poker hand. Optionally, multiple augmented final poker hands may be fanned from a single final poker hand by dealing additional cards from different decks to the same final poker hand. The augmented final poker hands are evaluated and a reward is issued based on the payout, if any, associated with the poker rank of each augmented final poker hand.

Abstract: A wagering game method includes dealing an initial poker hand, forming a final poker hand (optionally by discarding and replacing zero or more playing cards from the initial poker hand), and forming an augmented final poker hand by dealing additional cards to the final poker hand. Optionally, multiple augmented final poker hands may be formed from a single final poker hand by dealing additional cards from different decks to the same final poker hand. The augmented final poker hands are evaluated and a reward is issued based on the payout, if any, associated with the poker rank of each augmented final poker hand.

Abstract: A method and device utilize a data processor and a player interface, display, and data storage device in communication with the data processor, A wager is received; optionally the wager includes a poker wager and a matrix wager. An initial hand is dealt and a poker hand is formed. Optionally, a poker hand consists of cards held from an initial hand plus replacements for cards discarded from an initial hand. The payout, if any, associated with the poker hand may be issued. A matrix is constructed by randomly placing value/suit combinations in matrix locations. Matrix locations containing value/suit combinations matching cards in the poker hand are marked. The payout, if any, associated with patterns formed in the matrix by marked matrix locations may be issued.

Abstract: A method and device utilize a data processor and a player interface, display, and data storage device in communication with the data processor, A wager is received; optionally the wager includes a poker wager and a matrix wager. An initial hand is dealt and a poker hand is formed. Optionally, a poker hand consists of cards held from an initial hand plus replacements for cards discarded from an initial hand. The payout, if any, associated with the poker hand may be issued. A matrix is constructed by randomly placing value/suit combinations in matrix locations. Matrix locations containing value/suit combinations matching cards in the poker hand are marked. The payout, if any, associated with patterns formed in the matrix by marked matrix locations may be issued.

Abstract: A nonwoven material includes a backing substrate and a functional layer affixed to the backing substrate, the functional layer including thermal-setting fibers. The functional layer can be a nonwoven web including thermal-setting fibers, where the nonwoven web is affixed to the backing substrate. The functional layer can also include thermal-setting fibers and a thermal-setting polymer disposed on the backing substrate. The thermal-setting fibers can be melamine. Thermal-setting fibers can be rigidly fixed within the functional layer. The functional layer can further include a polymer resin.

Abstract: The present invention is directed to a process for making Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

Abstract: A dispersible moist wipe generally comprises a nonwoven tissue web having regenerated fibers in an amount of about 10 to about 30 percent by weight and natural fibers in an amount of about 70 to about 90 percent by weight. The regenerated fibers and the natural fibers are hydroentangled such that the web has a geometric mean tensile strength of at least 250 grams per inch and a slosh-box break-up time of less than 155 minutes.

Abstract: The present disclosure is generally directed to a dispersible moist wipe comprising hydroentangled fibers and a binder composition. The moist wipe demonstrates high initial wet strength while maintaining effective dispersion in an aqueous environment. The moist wipe has potential application as a flushable surface cleaning product and/or a flushable cleansing cloth.

Abstract: The present invention is directed to a process for making Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

Abstract: A method for making a dispersible nonwoven sheet generally comprises dispersing natural fibers and regenerated fibers in a ratio of about 70 to about 90 percent by weight natural fibers and about 10 to about 30 percent by weight regenerated fibers in a liquid medium to form a liquid suspension. The liquid suspension is deposited over a foraminous forming wire to form a nonwoven tissue web. The nonwoven tissue web is sprayed with a first plurality of jets. Each jet of the first plurality of jets is spaced from an adjacent one of the first plurality of jets by a first distance. The nonwoven tissue web also is sprayed with a second plurality of jets. Each jet of the second plurality of jets is spaced from an adjacent one of the second plurality of jets by a second distance, and the second distance is less than the first distance. The nonwoven tissue web is dried to form the dispersible nonwoven sheet.

Abstract: The present disclosure is generally directed to a dispersible moist wipe comprising hydroentangled fibers and a binder composition. The moist wipe demonstrates high initial wet strength while maintaining effective dispersion in an aqueous environment. The moist wipe has potential application as a flushable surface cleaning product and/or a flushable cleansing cloth.

Abstract: The present disclosure is generally directed to a dispersible moist wipe comprising hydroentangled fibers and a binder composition. The moist wipe demonstrates high initial wet strength while maintaining effective dispersion in an aqueous environment. The moist wipe has potential application as a flushable surface cleaning product and/or a flushable cleansing cloth.

Abstract: The present disclosure is generally directed to a dispersible moist wipe comprising hydroentangled fibers and a binder composition. The moist wipe demonstrates high initial wet strength while maintaining effective dispersion in an aqueous environment. The moist wipe has potential application as a flushable surface cleaning product and/or a flushable cleansing cloth.

Abstract: A storage-style clipboard has a quick-access weapon holder assembly. When triggered, the assembly moves from a concealed position to an accessible position. The weapon holder assembly may be accessed through a side or end wall of the clipboard box. The movement of the weapon holder assembly is actuated without the need for the user to remove his hand from the normal case-carrying position. The disclosure provides a recess accessible through one of the sides of the clipboard box with a grip and a trigger for release of the weapon holder sheltered in the recess. The recess provides protection for the user's hand and further hides from view the user's actions in releasing the weapon.

Abstract: The present disclosure is generally directed to a dispersible moist wipe comprising hydroentangled fibers and a binder composition. The moist wipe demonstrates high initial wet strength while maintaining effective dispersion in an aqueous environment. The moist wipe has potential application as a flushable surface cleaning product and/or a flushable cleansing cloth.