Patents by Inventor Kenneth C. Cundy

Kenneth C. Cundy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
    Patent number: 7645797
    Abstract: Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.
    Type: Grant
    Filed: May 28, 2008
    Date of Patent: January 12, 2010
    Assignee: XenoPort, Inc.
    Inventors: Mark Gallop, Kenneth C. Cundy, Randall A. Scheuerman, Ronald W. Barrett, Noa Zerangue
  • Levodopa Prodrugs, and Compositions and Uses Thereof
    Publication number: 20100004332
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Application
    Filed: September 14, 2009
    Publication date: January 7, 2010
    Applicant: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy
  • Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
    Patent number: 7608602
    Abstract: The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions of using gemcitabine prodrugs to treat or prevent diseases or disorders such as cancer or viral infections.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: October 27, 2009
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Ge Peng, Thomas F. Woiwode, Kenneth C. Cundy
  • Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration
    Patent number: 7601708
    Abstract: This invention is directed to methods for providing sustained systemic concentrations of therapeutic or prophylactic agents such as GABA analogs following oral administration to animals. This invention is also directed to compounds and pharmaceutical compositions that are used in such methods.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: October 13, 2009
    Assignee: XenoPort, Inc.
    Inventors: Kenneth C. Cundy, Mark A. Gallop, Cindy X. Zhou
  • Bile-acid conjugates providing for sustained systemic concentration of drugs
    Patent number: 7601706
    Abstract: This invention is directed to compounds that provide for sustained systemic concentrations of therapeutic or prophylactic agents following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: October 13, 2009
    Assignee: XenoPort, Inc.
    Inventors: Kenneth C. Cundy, Mark A. Gallop, Cindy X. Zhou
  • Bile-acid conjugates for providing sustained systemic concentrations of drugs
    Patent number: 7598235
    Abstract: This invention is directed to compounds that provide for sustained systemic concentrations of therapeutic or prophylactic agents following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
    Type: Grant
    Filed: September 6, 2005
    Date of Patent: October 6, 2009
    Assignee: XenoPort, Inc.
    Inventors: Kenneth C. Cundy, Mark A. Gallop
  • SUBSTRATES AND SCREENING METHODS FOR TRANSPORT PROTEINS
    Publication number: 20090221442
    Abstract: A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
    Type: Application
    Filed: July 14, 2008
    Publication date: September 3, 2009
    Applicant: XenoPort, Inc.
    Inventors: William J. Dower, Mark Gallop, Ronald W. Barrett, Kenneth C. Cundy, Tania Chernov-Rogan
  • Sustained Release Particulate Oral Dosage Forms of (R) Baclofen and Methods of Treatment
    Publication number: 20090197958
    Abstract: Sustained release particulate oral dosage forms of (R)-baclofen prodrugs and methods of treating a disease comprising orally administering such dosage forms are disclosed.
    Type: Application
    Filed: February 1, 2008
    Publication date: August 6, 2009
    Applicant: XenoPort, Inc.
    Inventors: Srikonsda SASTRY, Kenneth C. Cundy, Manshiu Leung
  • NUCLEOTIDE ANALOGS
    Publication number: 20090149648
    Abstract: Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
    Type: Application
    Filed: September 16, 2008
    Publication date: June 11, 2009
    Applicant: Gilead Sciences, Inc.
    Inventors: Norbert W. Bischofberger, Robert J. Jones, Murty N. Armilli, Kuei-Ying Lin, Michael S. Louie, Lawrence R. McGee, Ernest J. Prisbe, William A. Lee, Kenneth C. Cundy
  • LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF
    Publication number: 20090137834
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Application
    Filed: February 2, 2009
    Publication date: May 28, 2009
    Applicant: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy, Nelson L. Jumbe
  • Levodopa prodrugs, and compositions and uses thereof
    Patent number: 7534813
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: May 19, 2009
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy, Nelson L. Jumbe
  • USE OF PRODRUGS OF GABA ANALOGS, ANTISPASTICITY AGENTS, AND PRODRUGS OF GABA B RECEPTOR AGONISTS FOR TREATING SPASTICITY
    Publication number: 20090041806
    Abstract: Methods of treating spasticity by administering a colonically absorbable prodrug of a GABA analog having antispastic activity that is not directly mediated by the GABAB receptor, optionally in combination with an antispasticity agent or a colonically absorbable prodrug of a GABAB receptor agonist are disclosed. In particular, methods of treating spasticity by administering a colonically absorbable prodrug of gabapentin or a colonically absorbable prodrug of pregabalin, in combination with a colonically absorbable prodrug of R-baclofen are disclosed.
    Type: Application
    Filed: June 13, 2008
    Publication date: February 12, 2009
    Applicant: XenoPort, Inc.
    Inventor: Kenneth C. CUNDY
  • USE OF PROPOFOL PRODRUGS FOR TREATING ALCOHOL WITHDRAWAL, CENTRAL PAIN, ANXIETY OR PRURITUS
    Publication number: 20090005444
    Abstract: Methods of treating alcohol withdrawal, central pain, anxiety, or pruritus in a patient comprising orally administering a therapeutically effective amount of a propofol prodrug having high oral bioavailability are disclosed.
    Type: Application
    Filed: June 18, 2008
    Publication date: January 1, 2009
    Applicant: XenoPort, Inc.
    Inventors: Kenneth C. Cundy, Peter A. Virsik
  • Nucleotide analogs
    Patent number: 7439350
    Abstract: Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: October 21, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Norbert W. Bischofberger, Robert J. Jones, Murty N. Arimilli, Kuei-Ying Lin, Michael S. Louie, Lawrence R. McGee, Ernest J. Prisbe, William A. Lee, Kenneth C. Cundy
  • COMPOUNDS FOR SUSTAINED RELEASE OF ORALLY DELIVERED DRUGS
    Publication number: 20080255073
    Abstract: Disclosed are methods for providing sustained systemic blood concentrations of orally delivered drugs. Still further, disclosed are compounds and pharmaceutical compositions that are used in such methods.
    Type: Application
    Filed: May 28, 2008
    Publication date: October 16, 2008
    Applicant: XONOPORT, INC.
    Inventors: Mark A. GALLOP, Kenneth C. Cundy
  • AMINO ACID CONJUGATES PROVIDING FOR SUSTAINED SYSTEMIC CONCENTRATION OF GABA ANALOGUES
    Publication number: 20080226716
    Abstract: Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.
    Type: Application
    Filed: May 28, 2008
    Publication date: September 18, 2008
    Applicant: XenoPort
    Inventors: Mark Gallop, Kenneth C. Cundy, Randall A. Scheuerman, Ronald W. Barrett, Noa Zerangue
  • Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
    Patent number: 7420002
    Abstract: Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: September 2, 2008
    Assignee: Xenoport
    Inventors: Mark Gallop, Kenneth C. Cundy, Randall A. Scheuerman, Ronald W. Barrett, Noa Zerangue
  • SUSTAINED RELEASE ORAL DOSAGE FORMS OF A PRODRUG OF R-BACLOFEN AND METHODS OF TREATMENT
    Publication number: 20080206332
    Abstract: Sustained release oral dosage forms of R-baclofen and methods of treating diseases comprising orally administering such dosage forms are disclosed.
    Type: Application
    Filed: January 10, 2008
    Publication date: August 28, 2008
    Inventors: David J. Kidney, Kenneth C. Cundy, Srikonda Sastry, Manshiu Leung
  • Substrates and screening methods for transport proteins
    Patent number: 7413536
    Abstract: A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: August 19, 2008
    Assignee: XenoPort, Inc.
    Inventors: William J. Dower, Mark A. Gallop, Ronald W. Barrett, Kenneth C. Cundy, Tania Chernov-Rogan
  • Use of prodrugs of GABA analogs for treating disease
    Publication number: 20080161393
    Abstract: Methods of using prodrugs of GABA analogs and pharmaceutical compositions thereof to treat migraine, fibromyalgia, amyotrophic lateral sclerosis, irritable bowel syndrome, social phobia, Parkinson's disease, asthma, cough, or chronic obstructive pulmonary disease, and pharmaceutical compositions of prodrugs of GABA analogs useful in treating migraine, fibromyalgia, amyotrophic lateral sclerosis, irritable bowel syndrome, social phobia, Parkinson's disease, asthma, cough, or chronic obstructive pulmonary disease are disclosed.
    Type: Application
    Filed: December 6, 2007
    Publication date: July 3, 2008
    Inventors: Ronald W. Barrett, Kenneth C. Cundy