Patents by Inventor Kenneth E. Nichols

Kenneth E. Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11906521
    Abstract: The present invention is related to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising limulus amebocyte lysate (LAL) and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample; wherein the LAL is substantially free of coagulogen. The method also relates to compositions and kits comprising LAL substantially free of coagulogen, and methods of making such.
    Type: Grant
    Filed: September 23, 2021
    Date of Patent: February 20, 2024
    Assignee: LONZA WALKERSVILLE, INC.
    Inventors: Candice Stumbaugh, David S. Herbst, Kenneth E. Nichols, Jr.
  • Publication number: 20220074940
    Abstract: The present invention is related to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising limulus amebocyte lysate (LAL) and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample; wherein the LAL is substantially free of coagulogen. The method also relates to compositions and kits comprising LAL substantially free of coagulogen, and methods of making such.
    Type: Application
    Filed: September 23, 2021
    Publication date: March 10, 2022
    Inventors: Candice STUMBAUGH, David S. HERBST, Kenneth E. NICHOLS, JR.
  • Patent number: 11156614
    Abstract: The present invention is related to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising limulus amebocyte lysate (LAL) and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample; wherein the LAL is substantially free of coagulogen. The method also relates to compositions and kits comprising LAL substantially free of coagulogen, and methods of making such.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: October 26, 2021
    Assignee: Lonza Walkersville, Inc.
    Inventors: Candice Stumbaugh, David S. Herbst, Kenneth E. Nichols, Jr.
  • Publication number: 20180038864
    Abstract: The present invention is related to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising limulus amebocyte lysate (LAL) and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample; wherein the LAL is substantially free of coagulogen. The method also relates to compositions and kits comprising LAL substantially free of coagulogen, and methods of making such.
    Type: Application
    Filed: August 3, 2017
    Publication date: February 8, 2018
    Applicant: Lonza Walkersville, Inc.
    Inventors: Candice Stumbaugh, David S. HERBST, Kenneth E. NICHOLS, JR.
  • Publication number: 20040036774
    Abstract: A method for matching a photographic image with related identifying data, including the steps of creating a digital image that includes a datafile containing image time data, generating a signal when the digital image is created, and storing in a digital storage device identifying information relevant to the digital image. The identifying information also has information time data associated therewith. A signal is transmitted to the digital storage device and a time stamp is applied to the signal at the digital storage device. The image time data is stored in the digital storage device in time sequenced order. The image time data and the information time data are synchronized, and the digital image is associated with the identifying information by matching the synchronized image time data and the information time data.
    Type: Application
    Filed: February 28, 2003
    Publication date: February 26, 2004
    Inventors: James F. Nichols, Kenneth E. Nichols
  • Patent number: 6463738
    Abstract: A continuous power system provides a continuous supply of power to a load in the event that primary power fails or is degraded. The continuous power system includes an electrical machine, a turbine and a flywheel coupled to a shaft. When utility power is present, the machine operates as a motor to drive the shaft. During outages, the electrical machine operates as a generator to provide power to the load. Kinetic energy stored in the flywheel drives the shaft during initial power interruptions. During further short-term interruptions, a thermal energy supply (or thermal storage device) is used to provide vaporized liquid to the turbine so that the turbine drives the shaft. If the power loss or failure is extended, the turbine is driven by vapor produced by an evaporator heated from an external fuel supply. Numerous methods and apparatus are also described for reducing system losses and improving overall performance.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: October 15, 2002
    Assignee: Active Power, Inc.
    Inventors: Joseph F. Pinkerton, David B. Clifton, Kenneth E. Nichols, Michael D. Forsha, James E. Dillard, William D. Batton
  • Patent number: 5597103
    Abstract: A tool and material restraining platform for pickup trucks, which utilizes steel extruded into convoluted channels as the bed of the platform. Self-locking hardware devices are inserted therein, to provide a secure base from where chain link is placed under tension to restrain tools and materials of simple or complex and difficult shapes. This results in more reliable restraining methods than strapping, stretch cords, and ropes and the like. Furthermore, the hardware devices, adapt easy to use add-on and take-off options such as a rigid conduit container. In addition, the sides of the platform are made of aluminum for displaying unique patterns, logos, and custom designs, to achieve an enhanced appearance for the truck, as custom wheels do. Also in addition, for models equipped for use with truck bed caps, tool and material cradles are installed in the interior of the cap, to the mounting bolts of the platform, to utilize normally wasted space directly adjacent to the ceiling of the cargo cap.
    Type: Grant
    Filed: May 11, 1994
    Date of Patent: January 28, 1997
    Inventor: Kenneth E. Nichols
  • Patent number: 3961866
    Abstract: A geothermal energy transfer and utilization system extracts thermal energy stored in hot solute-bearing well water to generate super-heated steam from an injected flow of clean water; the super-heated steam is then used for driving a turbine-driven pump at the well bottom for pumping the hot solute-bearing water at high pressure and always in liquid state to the earth's surface, where it is used by transfer of its heat content to a closed-loop vapor generator-turbine-alternator combination for the generation of electrical or other power. Cooled, clean water is regenerated by the surface-located system for re-injection into the deep well and the residual concentrated solute-bearing water is pumped back into the earth. The invention features heat exchanger apparatus located adjacent the turbine-driven pump for permitting steam exhausted by the turbine to cool that part of the re-injected water used as a hydraulic bearing lubricant.
    Type: Grant
    Filed: August 14, 1974
    Date of Patent: June 8, 1976
    Assignee: Sperry Rand Corporation
    Inventor: Kenneth E. Nichols