Abstract: Pipette tip grids with holes for holding pipette tips and packages for the grids are provided. A pipette tip grid package comprises a grid, a base for supporting the grid, and a lock mechanism coupled to the grid and configured to externally engage with a sidewall of the base. The sidewall of the base also supports the grid. The package also can have a detachable cover for the grid, and, the lock mechanism can be external to the cover as well as the base. In some embodiments, the grids are stackable and the cover engages the topmost grid of the stack. Together, the cover, the base, and the sidewalls of the one or more stacked pipette tip grids form a protective case around pipette tips in the one or more grids.