Patents by Inventor Kenneth L. Mikolajczak

Kenneth L. Mikolajczak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Organic nitriles as insect antifeedants
    Patent number: 4966913
    Abstract: Members of a novel class of organic nitriles related to an indole alkaloid of Dithyrea wislizenii (Cruciferae) have been discovered to be patent feeding inhibitors of the fall armyworm and European corn borer.
    Type: Grant
    Filed: April 3, 1990
    Date of Patent: October 30, 1990
    Assignees: The United States of America as represented by the Secretary of Agriculture, Cornell Research Foundation, Inc.
    Inventors: Richard G. Powell, Kenneth L. Mikolajczak, Bruce W. Zilkowski, Jon Clardy, Ellen K. Mantus
  • Organic nitriles as insect antifeedants
    Patent number: 4942247
    Abstract: Members of a novel class of organic nitriles related to an indole alkoaloid of Dithyrea wislizenii (Cruciferae) have been discovered to be potent feeding inhibitors of the fall armyworm and European corn borer.
    Type: Grant
    Filed: June 27, 1989
    Date of Patent: July 17, 1990
    Assignees: The United States of America as represented by the Secretary of Agriculture, Cornell Research Foundation, Inc.
    Inventors: Richard G. Powell, Kenneth L. Mikolajczak, Bruce W. Zilkowski, Jon Clardy, Ellen K. Mantus
  • Control of pests with annonaceous acetogenins
    Patent number: 4855319
    Abstract: Tetrahydrofuranoid acetogenins characteristic of the Annonaceae plant family have been found to have potent pesticidal and feeding deterrent activity against a diverse variety of pests such as mosquito larvae, spider mites, aphids, the Mexican bean beetle, striped cucumber beetle, blowfly larvae, and nematodes.
    Type: Grant
    Filed: October 6, 1987
    Date of Patent: August 8, 1989
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Kenneth L. Mikolajczak, Jerry L. McLaughlin, James K. Rupprecht
  • Control of pests with annonaceous acetogenins
    Patent number: 4721727
    Abstract: Tetrahydrofuranoid acetogenins characteristic of the Annonaceae plant family have been found to have potent pesticidal and feeding deterrent activity against a diverse variety of pests such as mosquito larvae, spider mites, aphids, the Mexican bean beetle, striped cumcumber beetle, blowfly larvae, and nematodes.
    Type: Grant
    Filed: May 6, 1986
    Date of Patent: January 26, 1988
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Kenneth L. Mikolajczak, Jerry L. McLaughlin, James K. Rupprecht
  • Synthetic cephalotaxine esters having antileukemic P388 activity
    Patent number: 4203996
    Abstract: Six acyl esters of cephalotaxine have been synthesized by ordinary and standard procedures, and all have demonstrated chemotherapeutic activity against leukemia of the strain P388 in animals.
    Type: Grant
    Filed: January 3, 1979
    Date of Patent: May 20, 1980
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Kenneth L. Mikolajczak, Cecil R. Smith, Jr.
  • Synthetic cephalotaxine esters having antileukemic activity
    Patent number: 4152333
    Abstract: Six acyl esters of cephalotaxine have been synthesized by ordinary and standard procedures, and all have demonstrated chemotherapeutic activity against leukemia in animals.
    Type: Grant
    Filed: February 22, 1978
    Date of Patent: May 1, 1979
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Kenneth L. Mikolajczak, Cecil R. Smith, Jr.
  • Synthesis of antitumor alkaloid deoxyharringtonine and its precursor 3'-0-(5-methyl-2-oxohexanoyl)-cephalotaxine
    Patent number: 3959312
    Abstract: The alkaloid deoxyharringtonine and its precursor 3'-O-(5-methyl-2-oxohexanoyl)-cephalotaxine were synthesized according to the following preferred series of reactions: Ethyl t-butyl oxalate + 1-lithio-3-methylbut-1-yne .fwdarw. t-butyl 5-methyl-2-oxohex-3-ynoate .fwdarw. t-butyl 5-methyl-2-oxohexanoate .sup.-trifluoroacetic acid 5-methyl-2-oxohexanoic acid .sup.(COCl).sbsp.2 5-methyl-2-oxohexanoyl chloride .sup.cephalotaxine 3'-O-(5-methyl-2-oxohexanoyl)-cephalotaxine .sup.lithio methyl acetate deoxyharringtonine.
    Type: Grant
    Filed: December 20, 1974
    Date of Patent: May 25, 1976
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Kenneth L. Mikolajczak, Cecil R. Smith, Jr.