Abstract: The present invention provides an improved method for stably attaching a desired compound to a silaceous or silane-containing substrate, in particular a glass, porous silica, or oxidized silicon. This method in certain embodiments provides improvements over conventional methods for attaching desired compounds to silaceous or silane-containing substrate, e.g., glass, porous silica, or oxidized silicon materials, e.g. obviating the need for derivatization (e.g., epoxysilane derivatization) prior to attachment. More particularly, the present invention provides a method for stably attaching a desired compound comprising at least one amine and hydroxyl group (e.g., an aminopropanol containing compound), to a silaceous or silane-containing substrate, preferably underivatized (plain) glass, a porous silica, or oxidized silicon substance. The subject method is especially useful for the attachment of nucleic acid sequences, e.g.

Abstract: The disclosed invention provides a novel method for analyzing genomic DNA and expressed sequences using auxiliary oligonucleotides, preannealed to the single-stranded target nucleic acid to form a partially duplex target molecule, offers several advantages in the analysis of nucleic acid sequences by hybridization to genosensor arrays or “DNA chips”. Also provided is a method for directly analyzing and comparing patterns of gene expression at the level of transcription in different cellular samples.

Abstract: The present invention provides a method of arbitrary sequence oligonucleotide fingerprinting (ASOF), a novel technology which eliminates gel electrophoresis as a step in polymorphic marker analysis, species identification and transcriptional profiling. ASOF greatly increases the speed and throughput of analysis, with aconcomitant decrease in cost. Furthermore, the miniaturization and automation of ASOF analysis leads to an exceedingly increased throughput of nucleic acid analysis.

Abstract: A method and apparatus for identifying molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. Each test site includes a probe formed therein to bond with an associated target molecular structure. An electrical signal is applied to the test site and the electrical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.

Abstract: A method and apparatus for identifying molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. Each test site includes a probe formed therein to bond with an associated target molecular structure. An electrical signal is applied to the test site and the electrical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.