Patents by Inventor Kenneth M. Kent

Kenneth M. Kent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and cyclic carbonates for nucleotide analogues
    Patent number: 5686629
    Abstract: An improved method for the preparation of acyclic nucleotide analogues comprises first condensing a cyclic carbonate with a purine or pyrimidine base and then reacting the alkylated base with an activated phosphonate. Novel cyclic carbonates are employed to yield the desired phosphonylmethoxyalkyl nucleotide analogues.
    Type: Grant
    Filed: December 27, 1995
    Date of Patent: November 11, 1997
    Assignee: Gilead Sciences, Inc.
    Inventors: Norbert W. Bischofberger, Kenneth M. Kent
  • Method and cyclic carbonates for nucleotide analogues
    Patent number: 5514798
    Abstract: An improved method for the preparation of acyclic nucleotide analogues comprises first condensing a cyclic carbonate with a purine or pyrimidine base and then reacting the alkylated base with an activated phosphonate. Novel cyclic carbonates are employed to yield the desired phosphonylmethoxyalkyl nucleotide analogues.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: May 7, 1996
    Assignee: Gilead Sciences, Inc.
    Inventors: Norbert W. Bischofberger, Kenneth M. Kent
  • Monomethoxytrityl protected oligonucleotides bound to a solid support
    Patent number: 5204455
    Abstract: The present invention describes methods for the production of oligonucleotides under conditions which exploit the desirable characteristics, such as the property of sustaining high degrees of substitution, of functionalized organic polymeric supports while avoiding the sluggish kinetics and low rates of conversion which normally plague syntheses involving such solid supports. By employing the methods and materials disclosed, functionalized support, substituted to a degree of about 250 .mu.mol/g, can be utilized at greater than 98% conversion levels for each sequential nucleotide coupling cycle, to provide unprecedented amounts of isolated oligonucleotide per gram of solid support.
    Type: Grant
    Filed: February 10, 1992
    Date of Patent: April 20, 1993
    Inventors: Brian C. Froehler, Kenneth M. Kent, Sylvia Wu
  • Large scale synthesis of oligonucleotides and their associated analogs
    Patent number: 5164491
    Abstract: The present invention describes methods for the production of oligonucleotides under conditions which exploit the desirable characteristics, such as the property of sustaining high degrees of substitution, of functionalized organic polymeric supports while avoiding the sluggish kinetics and low rates of conversion which normally plague syntheses involving such solid supports. By employing the methods and materials disclosed, functionalized support, substituted to a degree of about 250 .mu.mol/g, can be utilized at greater than 98% conversion levels for each sequential nucleotide coupling cycle, to provide unprecedented amounts of isolated oligonucleotide per gram of solid support.
    Type: Grant
    Filed: June 15, 1989
    Date of Patent: November 17, 1992
    Assignee: Gilead Sciences
    Inventors: Brian C. Froehler, Kenneth M. Kent, Sylvia Wu