Abstract: Topical sphingosine-1-phosphate receptor agonist active agent formulations are provided. Aspects of the transdermal formulations include an amount of a sphingosine-1-phosphate receptor agonist active agent in combination with a topical delivery vehicle, e.g., a topical patch that includes an adhesive layer and a backing layer. Also provided are methods of topically delivering a therapeutically effective amount of a sphingosine-1-phosphate receptor agonist active agent to a subject, e.g., to treat a subject for a disease condition, such as an immune system disorder like multiple sclerosis, a hyperproliferative dermatological disorder, e.g., psoriasis, acne, etc. Packaged topical formulations, kits including such formulations, and methods of making such formulations are also provided.

Abstract: Rivastigmine transdermal compositions are provided. Aspects of the transdermal compositions include an active agent layer which includes rivastigmine and a solubility modulator, e.g., crosslinked acrylic acid polymer. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions.

Abstract: Topical sphingosine-1-phosphate receptor agonist active agent formulations are provided. Aspects of the transdermal formulations include an amount of a sphingosine-1-phosphate receptor agonist active agent in combination with a topical delivery vehicle, e.g., a topical patch that includes an adhesive layer and a backing layer. Also provided are methods of topically delivering a therapeutically effective amount of a sphingosine-1-phosphate receptor agonist active agent to a subject, e.g., to treat a subject for a disease condition, such as an immune system disorder like multiple sclerosis, a hyperproliferative dermatological disorder, e.g., psoriasis, acne, etc. Packaged topical formulations, kits including such formulations, and methods of making such formulations are also provided.

Abstract: An automatic water faucet device 1 for automatically discharging water when an object to be detected is detected has: a sensor 14 that detects the object; a first water discharge part 12 that performs foamy water discharge; a second water discharge part 13 that performs spray water discharge; and a controller 40 that performs control for switching between the foamy water discharge from the first water discharge part 12 and the spray water discharge from the second water discharge part 13, wherein the controller 40 performs the foamy water discharge from the first water discharge part 12 while the sensor 14 detects the object, and when the sensor 14 no longer detects the object, the controller 40 stops this foamy water discharge, and thereafter performs spray water discharge from the second water discharge part 13 for a predetermined period.

Abstract: The present invention provides a tolterodine-containing patch in which an adhesive layer is laminated on a backing, characterized in that the adhesive layer is obtainable by adding tolterodine to an adhesive base comprising a rubber adhesive, a tackifier resin, and a softener, wherein the tolterodine is present in the form of a free base in the adhesive base.

Abstract: Topical sphingosine-1-phosphate receptor agonist active agent formulations are provided. Aspects of the transdermal formulations include an amount of a sphingosine-1-phosphate receptor agonist active agent in combination with a topical delivery vehicle, e.g., a topical patch that includes an adhesive layer and a backing layer. Also provided are methods of topically delivering a therapeutically effective amount of a sphingosine-1-phosphate receptor agonist active agent to a subject, e.g., to treat a subject for a disease condition, such as an immune system disorder like multiple sclerosis, a hyperproliferative dermatological disorder, e.g., psoriasis, acne, etc. Packaged topical formulations, kits including such formulations, and methods of making such formulations are also provided.

Abstract: Topical sphingosine-1-phosphate receptor agonist active agent formulations are provided. Aspects of the transdermal formulations include an amount of a sphingosine-1-phosphate receptor agonist active agent in combination with a topical delivery vehicle, e.g., a topical patch that includes an adhesive layer and a backing layer. Also provided are methods of topically delivering a therapeutically effective amount of a sphingosine-1-phosphate receptor agonist active agent to a subject, e.g., to treat a subject for a disease condition, such as an immune system disorder like multiple sclerosis, a hyperproliferative dermatological disorder, e.g., psoriasis, acne, etc. Packaged topical formulations, kits including such formulations, and methods of making such formulations are also provided.

Abstract: An automatic water faucet device 1 includes: an electrolysis tank 37 that electrolyzes water to generate electrolyzed water; a second water discharge part 13 for discharging the electrolyzed water, a second flow path 18 that extends from the electrolysis tank 37 to the second water discharge part 13; a second solenoid valve 28 that switches between supply and blocking of normal water with respect to the electrolysis tank 37, and a controller 40 that controls the electrolysis tank 37 and the second solenoid valve 28. The controller 40 energizes the electrolysis tank 37 to discharge the electrolyzed water and thereafter stops the energization of the electrolysis tank 37 and maintains an open state of the second solenoid valve 28, to stop the supply of the electrolyzed water to the second flow path 18 and to supply normal water to the second flow path 18.

Abstract: Topical sphingosine-1-phosphate receptor agonist active agent formulations are provided. Aspects of the transdermal formulations include an amount of a sphingosine-1-phosphate receptor agonist active agent in combination with a topical delivery vehicle, e.g., a topical patch that includes an adhesive layer and a backing layer. Also provided are methods of topically delivering a therapeutically effective amount of a sphingosine-1-phosphate receptor agonist active agent to a subject, e.g., to treat a subject for a disease condition, such as an immune system disorder like multiple sclerosis, a hyperproliferative dermatological disorder, e.g., psoriasis, acne, etc. Packaged topical formulations, kits including such formulations, and methods of making such formulations are also provided.

Abstract: Rivastigmine transdermal compositions are provided. Aspects of the transdermal compositions include an active agent layer which includes rivastigmine and a solubility modulator, e.g., crosslinked acrylic acid polymer. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions.

Abstract: Rivastigmine transdermal compositions are provided. Aspects of the transdermal compositions include an active agent layer which includes rivastigmine and a solubility modulator, e.g., crosslinked acrylic acid polymer. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions.

Abstract: A water discharging device 2 that is installed so as to secure a predetermined opened space between a bowl 3 and the water discharging device 2, and discharges water toward this bowl 3, the water discharging device having a water discharge part 13 that jets waterdrops so as to spread the waterdrops at a predetermined angle ? from a water discharge port 13a, and is set so as to discharge water at a predetermined flow rate, wherein an average flow speed X (m/sec) and an average particle size Y (?m) of the waterdrops jetted from the water discharge part 13 satisfy a conditional expression of “Y?9300×X(?1.5)”.

Abstract: An automatic water faucet device 1 includes: an electrolysis tank 37 that electrolyzes water to generate electrolyzed water; a second water discharge part 13 for discharging the electrolyzed water, a second flow path 18 that extends from the electrolysis tank 37 to the second water discharge part 13; a second solenoid valve 28 that switches between supply and blocking of normal water with respect to the electrolysis tank 37, and a controller 40 that controls the electrolysis tank 37 and the second solenoid valve 28. The controller 40 energizes the electrolysis tank 37 to discharge the electrolyzed water and thereafter stops the energization of the electrolysis tank 37 and maintains an open state of the second solenoid valve 28, to stop the supply of the electrolyzed water to the second flow path 18 and to supply normal water to the second flow path 18.

Abstract: An automatic water faucet device 1 for automatically discharging water when an object to be detected is detected has: a sensor 14 that detects the object; a first water discharge part 12 that performs foamy water discharge; a second water discharge part 13 that performs spray water discharge; and a controller 40 that performs control for switching between the foamy water discharge from the first water discharge part 12 and the spray water discharge from the second water discharge part 13, wherein the controller 40 performs the foamy water discharge from the first water discharge part 12 while the sensor 14 detects the object, and when the sensor 14 no longer detects the object, the controller 40 stops this foamy water discharge, and thereafter performs spray water discharge from the second water discharge part 13 for a predetermined period.

Abstract: Rivastigmine transdermal compositions are provided. Aspects of the transdermal compositions include an active agent layer which includes rivastigmine and a solubility modulator, e.g., crosslinked acrylic acid polymer. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions.

Abstract: Topical sphingosine-1-phosphate receptor agonist active agent formulations are provided. Aspects of the transdermal formulations include an amount of a sphingosine-1-phosphate receptor agonist active agent in combination with a topical delivery vehicle, e.g., a topical patch that includes an adhesive layer and a backing layer. Also provided are methods of topically delivering a therapeutically effective amount of a sphingosine-1-phosphate receptor agonist active agent to a subject, e.g., to treat a subject for a disease condition, such as an immune system disorder like multiple sclerosis, a hyperproliferative dermatological disorder, e.g., psoriasis, acne, etc. Packaged topical formulations, kits including such formulations, and methods of making such formulations are also provided.

Abstract: Provided is an automatic faucet using a radio wave sensor, which is capable of preventing erroneous stop of water spouting, with a simple configuration. The automatic faucet (1) has a radio wave propagation space, a radio wave emitting port (27), and directivity setting device. The directivity setting device is configured to direct a radio wave being emitted from the radio wave emitting port (27), in such a manner that, during a water stopping state, the emitted radio wave lies along a spouting direction (A) along which washing water is to be spouted from a spout port (26), and, during a water spouting state, a part of the radio wave emitted disposed offset in a direction C, with respect to the spout port (26) interferes with a region of a peripheral surface of a stream (W) facing in the direction C.

Abstract: The present invention provides a tolterodine-containing patch in which an adhesive layer is laminated on a backing, characterized in that the adhesive layer is obtainable by adding tolterodine to an adhesive base comprising a rubber adhesive, a tackifier resin, and a softener, wherein the tolterodine is present in the form of a free base in the adhesive base.

Abstract: A water discharge system capable of preventing a mistaken detection to surely perform the stop of water discharge or continue the start of water discharge is provided. The water discharge system includes: a water discharge unit; a sensor unit configured to obtain information about an object to be detected through a reflected wave of a radiated radio wave; a control unit configured to control the start of water discharge from the water discharge unit based on a detective signal from the sensor unit; and a storage mechanics.

Abstract: A water discharge system capable of preventing a mistaken detection to surely perform the stop of water discharge or continue the start of water discharge is provided. The water discharge system includes: a water discharge unit; a sensor unit configured to obtain information about an object to be detected through a reflected wave of a radiated radio wave; a control unit configured to control the start of water discharge from the water discharge unit based on a detective signal from the sensor unit; and a storage mechanics.