Abstract: There is to provide a semiconductor device manufacturing method capable of improving reliability in a semiconductor device, including the following steps of: forming a semiconductor element on a semiconductor substrate, forming a wiring structure on the main surface of the semiconductor substrate, polishing the back surface of the semiconductor substrate, measuring the thickness of the semiconductor substrate, forming a back electrode on the back surface of the semiconductor substrate, and then cutting off the semiconductor substrate along the scribe region. In the step of measuring the thickness of the semiconductor substrate, it is measured in a portion where the main surface of the semiconductor substrate is bared without forming the insulating films included in the wiring structure.

Abstract: There is to provide a semiconductor device manufacturing method capable of improving reliability in a semiconductor device, including the following steps of: forming a semiconductor element on a semiconductor substrate, forming a wiring structure on the main surface of the semiconductor substrate, polishing the back surface of the semiconductor substrate, measuring the thickness of the semiconductor substrate, forming a back electrode on the back surface of the semiconductor substrate, and then cutting off the semiconductor substrate along the scribe region. In the step of measuring the thickness of the semiconductor substrate, it is measured in a portion where the main surface of the semiconductor substrate is bared without forming the insulating films included in the wiring structure.

Abstract: Disclosed are an advantageous method of industrial production of tert-butyl 3-oxobutylate, which is a useful intermediate for synthesis, characterized by reacting tert-butyl alcohol with diketene in the presence of 4-(tertiary amino) pyridine, and an industrially advantageous method of producing cephalosporin compounds or pharmaceutically acceptable salts thereof, using tert-butyl 3-oxobutylate as an intermediate.

Abstract: A method for producing 3-(3-oxobutyryloxymethyl)-3-cepham-4-carboxylic acids which are antibiotics or intermediates for the synthesis of antibiotics, at a low temperature in a very short period of time and in good yield, characterized by reacting a 3-hydroxylmethyl-3-cephem-4-carboxylic acid with diketene in the presence of a 4-(tertiary-amino)pyridine and if necessary, when a 7-acylamino-3-(3-oxobutyryloxymethyl)-3-cephem-4-carboxylic acid is obtained, subjecting it to deacylation at the 7-position thereof.

Abstract: Disclosed are an advantageous method of industrial production of tert-butyl 3-oxobutylate, which is a useful intermediate for synthesis, characterized by reacting tert-butyl alcohol with diketene in the presence of 4-(tertiary amino) pyridine, and an industrially advantageous method of producing cephalosporin compounds or pharmaceutically acceptable salts thereof, using tert-butyl 3-oxobutylate as an intermediate.

Abstract: A method for producing a compound of the formula; ##STR1## wherein R stands for a hydrogen atom, an acyl group or a protective group other than acyl groups, Q stands for a hydrogen atom or an ester residue, Y stands for the residue of a nucleophilic compound and the dotted line shows the double bond at 2- or 3- position of the cephem ring or a salt thereof, characterized by allowing a compound of the formula; ##STR2## [R, Q and the dotted line are of the same meaning as above] or a salt thereof to react with a nucleophilic compound or a salt thereof and a compound of the formula; ##STR3## wherein R.sup.1, R.sup.2, R.sup.3 independently stand for a hydrocarbon group having not more than 8 carbon atoms, or R.sup.1 and R.sup.2, R.sup.1 and R.sup.3 or R.sup.2 and R.sup.

Abstract: An advantageous method of producing in large amounts on a commercial scale 2-substituted oxyimino-3-oxobutyric acids, which are useful as intermediates in the synthesis of e.g. aminothiazole cephalosporins, is characterized by reacting a tert-butyl 2-substituted oxyimino-3-oxobutyrate with a hydrogen halide in an anhydrous organic solvent.

Abstract: A method of producing 3-alkanoyloxymethyl-3-cephem-4-carboxylic acids, which are useful as antibiotics or as intermediates in the synthesis of antibiotics, by reacting a 3-hydroxymethyl-3-cephem-4-carboxylic acid with a saturated fatty acid anhydride in an aqueous medium in the presence of an acid-acceptor base and a 4-(tertiary amino)pyridine.

Abstract: A method of producing a 4-halo-2-(substituted or unsubstituted)hydroxyimino-3-oxobutyric acid ester or amide, which is a synthetic intermediate of value for the production of cephalosporins containing an aminothiazole group, characterized by reacting a 2-(substituted or unsubstituted)-hydroxyimino-3-oxobutyric acid or an ester or amide thereof with a silylating agent and reacting the resulting novel 2-(substituted)hydroxyimino-3-silyloxy-3-butenoic acid ester or amide with a halogenating agent.

Abstract: A novel method of producing a cephalosporin compound of the formula ##STR1## wherein R.sup.1 is a hydrogen atom or an acyl group; R is a hydrogen atom or an ester residue; the dotted line means a double bond in 2- or 3-position of the cephem ring; and R.sup.4 is a nucleophilic compound residue, or a salt thereof, directedly in one step from a compound of the formula ##STR2## wherein R.sup.1, R and the dotted line have the meanings defined above, or a salt thereof, by reacting in the presence of an organic solvent the compound [II] or a salt thereof, a nucleophilic compound or a salt thereof, and (1) a trivalent or pentavalent cyclic phosphorus compound having a partial structure of the formula ##STR3## wherein W is an oxygen atom, a sulfur atom or NR.sup.2 ; W.sup.1 is an oxygen atom, a sulfur atom or NR.sup.3 ; and R.sup.2 and R.sup.

Abstract: Novel crystals of sodium 7.beta.-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1,2,3-th iadiazol-5-yl)thiomethyl] ceph-3-em-4-carboxylate showing characteristic peaks at interplanar spacings (d) of 9.3, 8.9, 5.3, 5.1, 4.4, 4.3 and 3.8 .ANG. in the powder X-ray diffraction pattern which are very stable and do not easily cause discoloration and decomposition.

Abstract: A method is provided for producing a 1,3,2-dioxaphosphole of the formula ##STR1## wherein ##STR2## respresents a benzene ring which may be substituted and R represents an aryl, alkoxy or aralkyloxy group which may be substituted, which comprises reacting a catechol compound of the formula ##STR3## wherein ##STR4## is an defined above, with a compound of the formula ##STR5## wherein X is a halogen atom and R is as defined above, at a temperature not higher than about 30.degree. C. in the presence of a base.

Abstract: An improvement, in per se known method for producing 7-aminocephem compound being important intermediate for producing antimicrobial substances, represented by the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a methoxy group and R.sup.2 is a residue of a thiol compound, or a salt or ester thereof, by reacting a compound of the formula: ##STR2## wherein R.sup.1 is as defined above and R is a carboxylic acid acyl group, or a salt or ester thereof, with a thiol compound or a salt thereof, is characterized in that the reaction is conducted in an organic solvent in the presence of a dihalophosphoric acid to give the compound [II] in high yield and high purity.

Abstract: A solid cephalosporin derivative having the formula: ##STR1## wherein X is chlorine or bromine, n is a number from zero to 6, is found to have high stability in storage and may be used as an active component of an antimicrobial composition.

Abstract: Penicillin-1-oxides are rearranged into the corresponding 3-desacetosycephalosporin derivatives in an inert organic solvent in the concomitant presence of an acid catalyst and an organic sulfide in a good yield and with a high purity.