Abstract: Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap between the lower margin of the valve leaflets and the interior of the conduit. In addition, the valve structures may include one or more valve sinuses created in a space between the valve leaflets and the conduit inner surface. Computational fluid dynamics and mechanical modeling may be used to design the valve leaflets with optimal characteristics. A heart valve structure may also incorporate a biodegradable component to which cells may adhere. The incorporated cells may arise from patient cells migrating to the biodegradable component, or the component may be pre-seeded with cells prior to implantation in a patient.

Abstract: Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap between the lower margin of the valve leaflets and the interior of the conduit. In addition, the valve structures may include one or more valve sinuses created in a space between the valve leaflets and the conduit inner surface. Computational fluid dynamics and mechanical modeling may be used to design the valve leaflets with optimal characteristics. A heart valve structure may also incorporate a biodegradable component to which cells may adhere The incorporated cells may arise from patient cells migrating to the biodegradable component, or the component may be pre-seeded with cells prior to implantation in a patient.

Abstract: The present invention relates to an implantable self-driven pump for use as a cavopulmonary assist device. The invention comprises an aortic turbine that uses some systemic blood from the left ventricle as an energy source and a venous pump that is coupled magnetically or mechanically to the turbine. The present invention more particularly relates to a cavopulmonary assist device (10) for a total cavopulmonary connection with superior vena cava-pulmonary artery anastomosis and inferior vena cava-pulmonary artery bridging via a conduit (9), said cavopulmonary assist device (10) comprising a pump unit (20) and a turbine unit (30) coupled by a shaft (401).

Abstract: The present invention relates to an implantable self-driven pump for use as a cavopulmonary assist device. The invention comprises an aortic turbine that uses some systemic blood from the left ventricle as an energy source and a venous pump that is coupled magnetically or mechanically to the turbine. The present invention more particularly relates to a cavopulmonary assist device (10) for a total cavopulmonary connection with superior vena cava-pulmonary artery anastomosis and inferior vena cava-pulmonary artery bridging via a conduit (9), said cavopulmonary assist device (10) comprising a pump unit (20) and a turbine unit (30) coupled by a shaft (401).

Abstract: The present disclosure relates to a system for manufacturing of vascular patches in the form pre-operative surgical planning prototypes providing optimized patient specific 3-D patch geometries. The present disclosure relates more particularly to a patch generation device for manufacturing of vascular patches in the form pre-operative surgical planning prototypes providing optimized patient-specific patch geometries, said patch generation device comprising a processing unit effectuating processing of the optimized patient-specific patch geometries.

Abstract: Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap between the lower margin of the valve leaflets and the interior of the conduit. In addition, the valve structures may include one or more valve sinuses created in a space between the valve leaflets and the conduit inner surface. Computational fluid dynamics and mechanical modeling may be used to design the valve leaflets with optimal characteristics. A heart valve structure may also incorporate a biodegradable component to which cells may adhere The incorporated cells may arise from patient cells migrating to the biodegradable component, or the component may be pre-seeded with cells prior to implantation in a patient.

Abstract: This invention is related to an operation scenario flow, mechanical modeling and analysis system comprising web based, (i) growth (ii) scaling and (iii) quality control aimed, patient based fast prototyping functions, for newborn and fetus cardiovascular repair operations, developed in order to be used for training of doctors and patient specific post surgery performance prediction in hospitals following and prior to, cardiovascular operations within the field of bioengineering in the health sector. Moreover it can be used for both vivo implantation plans of patient specific cardiovascular devices (custom cardiac valve and cardiac support pumps) and adaptation of said devices to the physiology of the patient.

Abstract: Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap between the lower margin of the valve leaflets and the interior of the conduit. In addition, the valve structures may include one or more valve sinuses created in a space between the valve leaflets and the conduit inner surface. Computational fluid dynamics and mechanical modeling may be used to design the valve leaflets with optimal characteristics. A heart valve structure may also incorporate a biodegradable component to which cells may adhere The incorporated cells may arise from patient cells migrating to the biodegradable component, or the component may be pre-seeded with cells prior to implantation in a patient.

Abstract: The present disclosure relates to a system for manufacturing of vascular patches in the form pre-operative surgical planning prototypes providing optimized patient specific 3-D patch geometries. The present disclosure relates more particularly to a patch generation device for manufacturing of vascular patches in the form pre-operative surgical planning prototypes providing optimized patient-specific patch geometries, said patch generation device comprising a processing unit effectuating processing of the optimized patient-specific patch geometries.

Abstract: A novel arterial cannula tip includes an elongated body having an expanded four-lobe swirl inducer and a diverging diffuser. The swirl inducer presents micro-scale blood-wetting features that help to enhance the jet or core of the flow of blood sufficiently to delay the onset of turbulence and facilitate a strongly coherent blood outflow jet as it enters the cannulated artery, while the diverging diffuser reduces exit force and promotes and laminar flow which mitigates intimal vascular damage owing to high wall shear stresses at regions of jet impingement. When used in conjunction with an aortic cannula, the device facilitates neuroprotection by way of improved cerebral perfusion.

Abstract: Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap between the lower margin of the valve leaflets and the interior of the conduit. In addition, the valve structures may include one or more valve sinuses created in a space between the valve leaflets and the conduit inner surface. Computational fluid dynamics and mechanical modeling may be used to design the valve leaflets with optimal characteristics. A heart valve structure may also incorporate a biodegradable component to which cells may adhere The incorporated cells may arise from patient cells migrating to the biodegradable component, or the component may be pre-seeded with cells prior to implantation in a patient.

Abstract: This invention is related to an operation scenario flow, mechanical modeling and analysis system comprising web based, (i) growth (ii) scaling and (iii) quality control aimed, patient based fast prototyping functions, for newborn and fetus cardiovascular repair operations, developed in order to be used for training of doctors and patient specific post surgery performance prediction in hospitals following and prior to, cardiovascular operations within the field of bioengineering in the health sector. Moreover it can be used for both vivo implantation plans of patient specific cardiovascular devices (custom cardiac valve and cardiac support pumps) and adaptation of said devices to the physiology of the patient.

Abstract: A novel arterial cannula tip includes an elongated body having an expanded four-lobe swirl inducer and a diverging diffuser. The swirl inducer presents micro-scale blood-wetting features that help to enhance the jet or core of the flow of blood sufficiently to delay the onset of turbulence and facilitate a strongly coherent blood outflow jet as it enters the cannulated artery, while the diverging diffuser reduces exit force and promotes and laminar flow which mitigates intimal vascular damage owing to high wall shear stresses at regions of jet impingement. When used in conjunction with an aortic cannula, the device facilitates neuroprotection by way of improved cerebral perfusion.

Abstract: Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap between the lower margin of the valve leaflets and the interior of the conduit. In addition, the valve structures may include one or more valve sinuses created in a space between the valve leaflets and the conduit inner surface. Computational fluid dynamics and mechanical modeling may be used to design the valve leaflets with optimal characteristics. A heart valve structure may also incorporate a biodegradable component to which cells may adhere The incorporated cells may arise from patient cells migrating to the biodegradable component, or the component may be pre-seeded with cells prior to implantation in a patient.

Abstract: A device for use in the total cavopulmonary connection (TCPC) in order to optimize its hemodynamics. Although the current procedure of choice for single ventricle heart repairs, the TCPC has reduced the post-operative mortality to the level of simpler types of congenital heart disease repairs, Fontan patients are still subjected to serious long-term complications. The TCPC procedure, which restores the vital separation between oxygenated and deoxygenated blood, also leads to an increased workload for the remaining single ventricle, as it is now responsible for pumping the blood through both the systemic and pulmonary circulation. The present device reduces this workload by altering the surgically created design of the TCPC. Improved fluid mechanics and reduced energy dissipation at the connection site translates into less work for the single ventricle and improved transport of deoxygenated blood to the lungs, which may in turn contribute to improved post-operative results and quality of life.