Patents by Inventor Keria F. Gean

Keria F. Gean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use
    Patent number: 5372807
    Abstract: The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collegen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.
    Type: Grant
    Filed: August 24, 1992
    Date of Patent: December 13, 1994
    Assignees: University of Medicine and Dentistry of New Jersey, Rutgers University
    Inventors: George J. Poiani, David J. Riley, Wei-Chi Liao, Joachim Kahn, Keria F. Gean