Abstract: A dialysis system has a module with a dialyzer configured to remove one or more substances from a dialysis solution as it passes through a dialyzer. The module has a fluid line, a sorbent cartridge, and a sodium control system adapted to actively alter a sodium concentration of dialysis solution passing through the fluid line as the dialysis solution exits the sorbent cartridge. The sodium control system has a conductivity sensor that sends a signal indicating the conductivity of the dialysis solution as the dialysis solution exits the sorbent cartridge, the conductivity meter being in communication with the sodium control system, a processor configured to receive the signal from the conductivity sensor, compare the conductivity signal to a threshold value lower than a prescription value, and cause the sodium control system to stop actively altering the sodium concentration if the signal is greater than the threshold value.

Abstract: A spectroscopic detection system includes a sensor configured to reflect light of a first wavelength associated with a presence of a reference substance on the sensor and configured to reflect light of a second wavelength associated with a presence of a monitored substance on the sensor, wherein the monitored substance flows to the sensor from a circulating fluid. The spectroscopic detection system further includes a detector that has first and second channels for respectively receiving the light of the first and second wavelengths reflected from the sensor and one or more processors in electrical communication with the detector and configured to identify an excess condition of the monitored substance with respect to the circulating fluid based on a ratio of a second amount of the light of the second wavelength received at the detector to a first amount of the light of the first wavelength received at the detector.

Abstract: A sorbent cartridge device and a dialysis system comprising a dialysate generation machine dialysate generation machine, a pump adapted to move fluid through the dialysate generation machine, and a sorbent cartridge are described. The sorbent cartridge device fluidically connected to the dialysate generation machine.

Abstract: A spectroscopic detection system includes a sensor configured to reflect light of a first wavelength associated with a presence of a reference substance on the sensor and configured to reflect light of a second wavelength associated with a presence of a monitored substance on the sensor, wherein the monitored substance flows to the sensor from a circulating fluid. The spectroscopic detection system further includes a detector that has first and second channels for respectively receiving the light of the first and second wavelengths reflected from the sensor and one or more processors in electrical communication with the detector and configured to identify an excess condition of the monitored substance with respect to the circulating fluid based on a ratio of a second amount of the light of the second wavelength received at the detector to a first amount of the light of the first wavelength received at the detector.

Abstract: A spectroscopic detection system includes a sensor configured to reflect light of a first wavelength associated with a presence of a reference substance on the sensor and configured to reflect light of a second wavelength associated with a presence of a monitored substance on the sensor, wherein the monitored substance flows to the sensor from a circulating fluid. The spectroscopic detection system further includes a detector that has first and second channels for respectively receiving the light of the first and second wavelengths reflected from the sensor and one or more processors in electrical communication with the detector and configured to identify an excess condition of the monitored substance with respect to the circulating fluid based on a ratio of a second amount of the light of the second wavelength received at the detector to a first amount of the light of the first wavelength received at the detector.

Abstract: Cartridges useful in regenerating or purifying dialysis solutions are described as well as methods to regenerate or purify spent dialysis solutions. Dialysis methods using the sorbent cartridges of the present invention are further described.

Abstract: A method is provided for regenerating spent zirconium phosphate for reuse in sorbent dialysis treatments or other re-uses as a sorbent material. The method includes contacting spent zirconium phosphate with an aqueous disinfectant solution having at least one antimicrobial agent, and treating the resulting disinfected zirconium phosphate with an acidic solution to provide a treated zirconium phosphate that can be re-used as a sorbent material. Sorbent cartridge products containing the regenerated spent zirconium phosphate are also provided. Methods and systems for sorbent dialysis which re-use the regenerated zirconium phosphate such as part of sorbent cartridges, additionally are provided.

Abstract: Cartridges useful in regenerating or purifying dialysis solutions are described as well as methods to regenerate or purify spent dialysis solutions. Dialysis methods using the sorbent cartridges of the present invention are further described.

Abstract: A method is provided for regenerating spent zirconium phosphate for reuse in sorbent dialysis treatments or other re-uses as a sorbent material. The method includes contacting spent zirconium phosphate with an aqueous disinfectant solution having at least one antimicrobial agent, and treating the resulting disinfected zirconium phosphate with an acidic solution to provide a treated zirconium phosphate that can be re-used as a sorbent material. Sorbent cartridge products containing the regenerated spent zirconium phosphate are also provided. Methods and systems for sorbent dialysis which re-use the regenerated zirconium phosphate such as part of sorbent cartridges, additionally are provided.