Patents by Inventor Kerry E. Benenato

Kerry E. Benenato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid nanoparticle formulation
    Patent number: 11969506
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include an ionizable lipid, a phospholipid, a first sterol or a tocopherol, and optionally a second sterol different from the first sterol. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: April 30, 2024
    Assignees: ModernaTX, Inc., Oregon State University
    Inventors: Siddharth Patel, Emily Robinson, Anna Brown, Orn Almarsson, Kerry E. Benenato, Staci Sabnis, Gaurav Sahay, Ashwani Kumar Narayana
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20240124388
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: September 14, 2023
    Publication date: April 18, 2024
    Inventors: Kerry E. BENENATO, Mark CORNEBISE
  • BRANCHED TAIL LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20230286903
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: February 3, 2023
    Publication date: September 14, 2023
    Inventors: Kerry E. BENENATO, Mark Cornebise, Edward Hennessy, Ellalahewage S. Kumarasinghe
  • Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 11597698
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: March 7, 2023
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise, Edward Hennessy, Ellalahewage S. Kumarasinghe
  • NOVEL HEADGROUP LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20230000773
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: September 18, 2020
    Publication date: January 5, 2023
    Inventors: Kerry E. BENENATO, Mark CORNEBISE, Edward HENNESSY, Andrew MCKENZIE
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20220409536
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: September 19, 2019
    Publication date: December 29, 2022
    Inventors: Kerry E. BENENATO, Mark CORNEBISE, Edward HENNESSY
  • CARBONATE CONTAINING LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20220411361
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: September 18, 2020
    Publication date: December 29, 2022
    Inventors: Kerry E. BENENATO, Souvik BISWAS, Mark CORNEBISE, Edward HENNESSY, Ellalahewage S. KUMARASINGHE
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20220380299
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: November 30, 2021
    Publication date: December 1, 2022
    Inventors: Kerry E. BENENATO, Mark CORNEBISE
  • BRANCHED TAIL LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20220106259
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: May 19, 2021
    Publication date: April 7, 2022
    Inventors: Kerry E. BENENATO, Mark CORNEBISE, Edward HENNESSY, Ellalahewage S. KUMARASINGHE
  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 11220476
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: January 11, 2022
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise
  • Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 11066355
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: July 20, 2021
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise, Edward Hennessy, Ellalahewage S. Kumarasinghe
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF AGENTS
    Publication number: 20210198200
    Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: June 14, 2018
    Publication date: July 1, 2021
    Inventors: Kerry E. BENENATO, William BUTCHER
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF AGENTS
    Publication number: 20210161829
    Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: August 12, 2020
    Publication date: June 3, 2021
    Inventors: Kerry E. BENENATO, William BUTCHER
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20210154148
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: September 23, 2020
    Publication date: May 27, 2021
    Inventors: Kerry E. BENENATO, Ellalahewage Sathyajith KUMARASINGHE, Mark CORNEBISE
  • BRANCHED TAIL LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20210087135
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: September 18, 2020
    Publication date: March 25, 2021
    Inventors: Kerry E. BENENATO, Mark CORNEBISE, Edward HENNESSY, Ellalahewage S. KUMARASINGHE
  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 10857105
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: December 8, 2020
    Assignee: MordernaTX, Inc.
    Inventors: Kerry E. Benenato, Ellalahewage Sathyajith Kumarasinghe, Mark Cornebise
  • Compounds and compositions for intracellular delivery of agents
    Patent number: 10799463
    Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: October 13, 2020
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, William Butcher
  • LIPID NANOPARTICLE FORMULATION
    Publication number: 20200129445
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include an ionizable lipid, a phospholipid, a first sterol or a tocopherol, and optionally a second sterol different from the first sterol. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: March 15, 2018
    Publication date: April 30, 2020
    Inventors: Siddharth PATEL, Emily ROBINSON, Anna BROWN, Orn ALMARSSON, Kerry E. BENENATO, Staci SABNIS, Gaurav SAHAY, Ashwani Kumar NARAYANA
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20200123100
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: August 29, 2019
    Publication date: April 23, 2020
    Inventors: Kerry E. BENENATO, Mark CORNEBISE
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20190314292
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: April 12, 2019
    Publication date: October 17, 2019
    Inventors: Kerry E. BENENATO, Ellalahewage Sathyajith KUMARASINGHE, Mark CORNEBISE