Patents by Inventor Kerry Spear
Kerry Spear has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20080058395Abstract: This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. Also provided are methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein Q is a member selected from O, S, CR1 and N, X and Y are members independently selected from CR2, O, S, N and NR3.Type: ApplicationFiled: July 2, 2007Publication date: March 6, 2008Applicant: SEPRACOR INC.Inventors: Michele Heffernan, James Dorsey, Qun Fang, Robert Foglesong, Seth Hopkins, Michael Jones, Steven Jones, Cyprian Ogbu, Joe Perales, Mustapha Soukri, Kerry Spear, Mark Varney
-
Publication number: 20080004327Abstract: This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CR1 and N. X and Y are members independently selected from O, S, CR2, N and NH. R1, R2 and R4 are members independently selected from H and F, provided that at least one member selected from R1, R2 and R4 is F. R6 is a member selected from O?X+ and OH, wherein X+ is a positive ion, which is a member selected from inorganic positive ions and organic positive ions.Type: ApplicationFiled: July 2, 2007Publication date: January 3, 2008Applicant: SEPRACOR INC.Inventors: Michele Heffernan, Robert Foglesong, Seth Hopkins, Mustapha Soukri, Steven Jones, Kerry Spear, Mark Varney
-
Publication number: 20080004328Abstract: This invention provides fused heterocycles having the formula: in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R2 is a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R3is a member selected from the group consisting of H, C1-C6 substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R4 is a member selected from OH and O?X+, in which X+ is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula: in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl.Type: ApplicationFiled: August 3, 2007Publication date: January 3, 2008Applicant: SEPRACOR INC.Inventors: James Dorsey, Michele Heffernan, Qun Fang, Robert Foglesong, Seth Hopkins, Cyprian Ogbu, Mustapha Soukri, Kerry Spear
-
Publication number: 20070105832Abstract: Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd? are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.Type: ApplicationFiled: April 4, 2006Publication date: May 10, 2007Inventors: Thomas Bannister, Cassandra Celatka, Nizal Chandrakumar, Hongfeng Deng, Zihong Guo, Lei Jin, Tsvetelina Lazarova, Jian Lin, Scott Moe, Pamela Nagafuji, Manuel Navia, Amy Ripka, Michael Rynkiewicz, Kerry Spear, James Stickler, Roger Xie
-
Publication number: 20070027200Abstract: The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.Type: ApplicationFiled: September 29, 2006Publication date: February 1, 2007Applicant: ICAGEN, INC.Inventors: Xiaodong Wang, Alan Fulp, Albert van Rhee, Kerry Spear
-
Publication number: 20050267089Abstract: The present invention provides a genus of polycyclic pyrimidines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.Type: ApplicationFiled: April 13, 2005Publication date: December 1, 2005Applicants: ICAgen, Inc., Astellas Pharma Inc.Inventors: Xiaodong Wang, Kerry Spear, Alan Fulp, Darrick Seconi, Takeshi Suzuki, Takahiro Ishii, Ayako Moritomo
-
Publication number: 20050239800Abstract: The present invention provides a genus of polycyclic pyrazines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.Type: ApplicationFiled: April 13, 2005Publication date: October 27, 2005Applicants: ICAgen, Inc., Astellas Pharma Inc.Inventors: Xiaodong Wang, Kerry Spear, Alan Fulp, Darrick Seconi, Takeshi Suzuki, Takahiro Ishii, Ayako Moritomo
-
Publication number: 20050227958Abstract: The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.Type: ApplicationFiled: April 13, 2005Publication date: October 13, 2005Applicant: ICAgen, Inc.Inventors: Xiaodong Wang, Kerry Spear, Alan Fulp, Darrick Seconi
-
Publication number: 20050227989Abstract: The present invention provides a genus of polycyclic thiazoles that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.Type: ApplicationFiled: April 13, 2005Publication date: October 13, 2005Applicants: ICAgen, Inc., Astellas Pharma Inc.Inventors: Xiaodong Wang, Kerry Spear, Alan Fulp, Darrick Seconi, Takeshi Suzuki, Takahiro Ishii, Ayako Moritomo, Hideki Kubota
-
Patent number: 5877278Abstract: A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two "sub-monomers" directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by --NH.sub.2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound .alpha.-haloacetamide) with a sufficient amount of a second sub-monomer comprising an --NH.sub.2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like.Type: GrantFiled: June 7, 1995Date of Patent: March 2, 1999Assignee: Chiron CorporationInventors: Ronald N. Zuckermann, Dane A. Goff, Simon Ng, Kerry Spear, Barbara O. Scott, Aaron C. Sigmund, Richard A. Goldsmith, Charles K. Marlowe, Yazhong Pei, Lutz Richter, Reyna Simon
-
Patent number: 5525623Abstract: Compositions and methods for the prevention and treatment of immunomediated inflammatory disorders, especially for those disorders associated with the respiratory tract, are provided. More particularly, a tryptase inhibitor, typically a hydroxyaroyl or hydroxyheteroaroyl substituted dipeptide, is administered. Also provided by this invention are pharmaceutical compositions, typically aerosol or topical, as well as aerosol devices for administering these compositions intranasally.Type: GrantFiled: March 11, 1994Date of Patent: June 11, 1996Assignee: Arris Pharmaceutical CorporationInventors: Kerry Spear, Charles Johnson, Heinz W. Gschwend