Patents by Inventor Kesavan Balakumaran

Kesavan Balakumaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMPROVED PROCESS FOR PREPARATION OF AMORPHOUS LINACLOTIDE
    Publication number: 20170275335
    Abstract: The present application relates to an improved process for the formation of disulfide bonds in linaclotide. The present application also relates to an improved process for the purification of linaclotide.
    Type: Application
    Filed: July 21, 2015
    Publication date: September 28, 2017
    Inventors: Dipak KALITA, Ramrao Jogdand NIVRUTTI, Kesavan BALAKUMARAN, Shivshankar DESHMUKH, Naga Chandra Sekhar VUTUKURU, Vara Prasad KASINA, Sivannarayana NALAMOTHU, Mohan Sundaram VILVA, Rashid Abdul Rehman KHAN, Ramreddy TIRUMALAREDDY, Sairam MUSTOORI
  • Process for the manufacture of Degarelix and its intermediates
    Patent number: 9260480
    Abstract: The present invention relates to a liquid (or solution)-phase manufacturing process for preparing the decapeptide Degareiix, its amino-protected precursor, and other useful intermediates. The invention further relates to polypeptides useful in the solution-phase manufacturing process and to the purification of Degareiix itself. The manufacturing process comprises the step of cleaving the ?-amino protecting group P? from a Degareiix precursor according to formula {P4)(P?)Ac-AA1-AA10-NH2 in an organic solvent comprising the precursor and a cleaving agent dissolved therein: wherein P4 is a hydroxyl-protecting group or hydrogen, preferably hydrogen.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: February 16, 2016
    Assignee: Ferring B.V.
    Inventors: Dipak Kalita, Mohosin Layek, Atmakuri Venkata Dhanunjaya Rao, Venkat Aravinda Potula, Vikas Gajare, Kesavan Balakumaran, Anders Nilsson, Guangcheng Jiang
  • PROCESS FOR THE MANUFACTURE OF DEGARELIX AND ITS INTERMEDIATES
    Publication number: 20130281662
    Abstract: The present invention relates to a liquid (or solution)-phase manufacturing process for preparing the decapeptide Degareiix, its amino-protected precursor, and other useful intermediates. The invention further relates to polypeptides useful in the solution-phase manufacturing process and to the purification of Degareiix itself. The manufacturing process comprises the step of cleaving the ?-amino protecting group P? from a Degareiix precursor according to formula {P4)(P?)Ac-AA1-AA10-NH2 in an organic solvent comprising the precursor and a cleaving agent dissolved therein: wherein P4 is a hydroxyl-protecting group or hydrogen, preferably hydrogen.
    Type: Application
    Filed: October 26, 2011
    Publication date: October 24, 2013
    Applicant: Ferring B.V.
    Inventors: Dipak Kalita, Mohosin Layek, Atmakuri Venkata Dhanunjaya Rao, Venkat Aravinda Potula, Vikas Gajare, Kesavan Balakumaran, Anders Nilsson, Guangcheng Jiang