Patents by Inventor Kesheng Zhao

Kesheng Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preventing mitochondrial permeability transition
    Patent number: 7576061
    Abstract: The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: August 18, 2009
    Assignees: Cornell Research Foundation, Inc., Institute de Recherches Clinques de Montreal
    Inventors: Hazel H. Szeto, Kesheng Zhao, Peter W. Schiller
  • METHODS FOR PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION
    Publication number: 20070027087
    Abstract: The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
    Type: Application
    Filed: June 30, 2006
    Publication date: February 1, 2007
    Inventors: Hazel Szeto, Kesheng Zhao, Peter Schiller
  • Method and carrier complexes for delivering molecules to cells
    Publication number: 20050158373
    Abstract: The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
    Type: Application
    Filed: May 3, 2004
    Publication date: July 21, 2005
    Inventors: Hazel Szeto, Kesheng Zhao, Hugh Robertson, Alex Birk
  • Methods for preventing mitochondrial permeability transition
    Publication number: 20040248808
    Abstract: The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
    Type: Application
    Filed: February 3, 2004
    Publication date: December 9, 2004
    Inventors: Hazel H. Szeto, Kesheng Zhao, Peter W. Schiller