Patents by Inventor Kestas P. PARAKININKAS
Kestas P. PARAKININKAS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11815311Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.Type: GrantFiled: September 6, 2022Date of Patent: November 14, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. Johnson, Rylan A. Summit, Dennis A. Bridges, Dennis J. Hlavinka, Kestas P. Parakininkas, Kirk L. Weimer, Michael Lawrence Glover, Alexander Du Nguyen, Margaret V. Kwiat
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Publication number: 20230358471Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.Type: ApplicationFiled: July 11, 2023Publication date: November 9, 2023Inventors: Kestas P. PARAKININKAS, Eric T. HANSEN, Kirk L. WEIMER, Nathaniel T. JOHNSON, Dennis J. HLAVINKA
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Patent number: 11747082Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.Type: GrantFiled: November 28, 2022Date of Patent: September 5, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Kestas P. Parakininkas, Eric T. Hansen, Kirk L. Weimer, Nathaniel T. Johnson, Dennis J. Hlavinka
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Patent number: 11740019Abstract: Provided is a loading tray assembly for housing a lyophilization container and a related system and method. The loading tray assembly includes a chassis including a contact void configured to facilitate direct contact between the attached lyophilization container and a lyophilizer shelf. The method includes securing a multi-part lyophilization container including a peelable seal on a lyophilization loading tray assembly, inputting a liquid into a non-breathable section of the lyophilization container, loading the tray assembly into a lyophilizer, freezing the liquid, applying heat energy and a vacuum, the vacuum causing an opening of the peelable seal and occluding the lyophilization container to isolate the frozen liquid.Type: GrantFiled: December 1, 2022Date of Patent: August 29, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. Johnson, Dennis A. Bridges, Alexander Du Nguyen, Margaret V. Kwiat, Kestas P. Parakininkas, Rylan A. Summit
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Patent number: 11634257Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and an occlusion zone encompassing a boundary between the non-breathable section and the breathable section. The non-breathable section is configured to accommodate any of a liquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas.Type: GrantFiled: September 2, 2020Date of Patent: April 25, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Kirk L. Weimer, Nate T. Johnson, Dennis J. Hlavinka, Kestas P. Parakininkas
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Publication number: 20230098194Abstract: Provided is a loading tray assembly for housing a lyophilization container and a related system and method. The loading tray assembly includes a chassis including a contact void configured to facilitate direct contact between the attached lyophilization container and a lyophilizer shelf. The method includes securing a multi-part lyophilization container including a peelable seal on a lyophilization loading tray assembly, inputting a liquid into a non-breathable section of the lyophilization container, loading the tray assembly into a lyophilizer, freezing the liquid, applying heat energy and a vacuum, the vacuum causing an opening of the peelable seal and occluding the lyophilization container to isolate the frozen liquid.Type: ApplicationFiled: December 1, 2022Publication date: March 30, 2023Inventors: Nathaniel T. JOHNSON, Dennis A. BRIDGES, Alexander Du NGUYEN, Margaret V. KWIAT, Kestas P. PARAKININKAS, Rylan A. SUMMIT
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Publication number: 20230086359Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.Type: ApplicationFiled: November 28, 2022Publication date: March 23, 2023Inventors: Kestas P. PARAKININKAS, Eric T. HANSEN, Kirk L. WEIMER, Nathaniel T. JOHNSON, Dennis J. HLAVINKA
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Patent number: 11609042Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.Type: GrantFiled: March 11, 2020Date of Patent: March 21, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Kestas P. Parakininkas, Eric T. Hansen, Kirk L. Weimer, Nathaniel T. Johnson, Dennis J. Hlavinka
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Patent number: 11609043Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.Type: GrantFiled: March 11, 2020Date of Patent: March 21, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. Johnson, Rylan A. Summit, Dennis A. Bridges, Dennis J. Hlavinka, Kestas P. Parakininkas, Kirk L. Weimer, Michael Lawrence Glover, Alexander Du Nguyen, Margaret V. Kwiat
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Patent number: 11604026Abstract: Provided is a loading tray assembly for housing a lyophilization container and a related system and method. The loading tray assembly includes a chassis including a contact void configured to facilitate direct contact between the attached lyophilization container and a lyophilizer shelf. The method includes securing a multi-part lyophilization container including a peelable seal on a lyophilization loading tray assembly, inputting a liquid into a non-breathable section of the lyophilization container, loading the tray assembly into a lyophilizer, freezing the liquid, applying heat energy and a vacuum, the vacuum causing an opening of the peelable seal and occluding the lyophilization container to isolate the frozen liquid.Type: GrantFiled: March 11, 2020Date of Patent: March 14, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. Johnson, Dennis A. Bridges, Alexander Du Nguyen, Margaret V. Kwiat, Kestas P. Parakininkas, Rylan A. Summit
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Publication number: 20230008773Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.Type: ApplicationFiled: September 6, 2022Publication date: January 12, 2023Applicant: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. JOHNSON, Rylan A. SUMMIT, Dennis A. BRIDGES, Dennis J. HLAVINKA, Kestas P. PARAKININKAS, Kirk L. WEIMER, Michael Lawrence GLOVER, Alexander Du NGUYEN, Margaret V. KWIAT
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Patent number: 11460248Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.Type: GrantFiled: March 11, 2020Date of Patent: October 4, 2022Assignee: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. Johnson, Rylan A. Summit, Dennis A. Bridges, Dennis J. Hlavinka, Kestas P. Parakininkas, Kirk L. Weimer, Michael Lawrence Glover, Alexander Du Nguyen, Margaret V. Kwiat
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Publication number: 20210016943Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and an occlusion zone encompassing a boundary between the non-breathable section and the breathable section. The non-breathable section is configured to accommodate any of a liquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas.Type: ApplicationFiled: September 2, 2020Publication date: January 21, 2021Applicant: Terumo BCT Biotechnologies, LLCInventors: Kirk L. WEIMER, Nate T. JOHNSON, Dennis J. HLAVINKA, Kestas P. PARAKININKAS
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Patent number: 10793327Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and an occlusion zone encompassing a boundary between the non-breathable section and the breathable section. The non-breathable section is configured to accommodate any of a liquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas.Type: GrantFiled: October 9, 2018Date of Patent: October 6, 2020Assignee: Terumo BCT Biotechnologies, LLCInventors: Kirk L. Weimer, Nate T. Johnson, Dennis J. Hlavinka, Kestas P. Parakininkas
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Publication number: 20200289728Abstract: Provided is a loading tray assembly for housing a lyophilization container and a related system and method. The loading tray assembly includes a chassis including a contact void configured to facilitate direct contact between the attached lyophilization container and a lyophilizer shelf. The method includes securing a multi-part lyophilization container including a peelable seal on a lyophilization loading tray assembly, inputting a liquid into a non-breathable section of the lyophilization container, loading the tray assembly into a lyophilizer, freezing the liquid, applying heat energy and a vacuum, the vacuum causing an opening of the peelable seal and occluding the lyophilization container to isolate the frozen liquid.Type: ApplicationFiled: March 11, 2020Publication date: September 17, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. JOHNSON, Dennis A. BRIDGES, Alexander Du NGUYEN, Margaret V. KWIAT, Kestas P. PARAKININKAS, Rylan A. SUMMIT
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Publication number: 20200292231Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.Type: ApplicationFiled: March 11, 2020Publication date: September 17, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. JOHNSON, Rylan A. SUMMIT, Dennis A. BRIDGES, Dennis J. HLAVINKA, Kestas P. PARAKININKAS, Kirk L. WEIMER, Michael Lawrence GLOVER, Alexander Du NGUYEN, Margaret V. KWIAT
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Publication number: 20200288703Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.Type: ApplicationFiled: March 11, 2020Publication date: September 17, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Kestas P. PARAKININKAS, Eric T. HANSEN, Kirk L. WEIMER, Nathaniel T. JOHNSON, Dennis J. HLAVINKA