Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: Utilization data of reserved virtual machine (VM) instances can be obtained from a cloud service provider. A refund recommendation comprising a first quantity of VM instances and a refund credit associated with the first quantity of VM instances can be generated based on the utilization data. A purchase recommendation comprising a second quantity of VM instances and a purchase cost associated with the second quantity of VM instances can be generated. An exchange transaction to return the first quantity of VM instances and purchase the second quantity of VM instances can be generated, where a net total of the exchange transaction is determined based on the refund credit and the purchase cost.

Abstract: The present disclosure provides chimeric antigen receptors, compostions, and methods thereof. In one embodiment the present disclosure provides a method of treating autoimmune diseases, asthma, and preventing or mediating organ rejection in a subject.

Abstract: Document difference viewing and navigation are disclosed that enables automatic comparison and easy viewing of the difference between many documents (e.g., four or more, dozens, hundreds, or thousands of documents) for, for example, document review processes. The system receives and reads a set of documents containing text. The system identifies shared text and differences by location within the shared text among different documents in the set of documents. It sorts the documents in the set of documents into groups of different text variation versions and generates a shared difference document. The shared difference document is displayed in a first panel of a user interface and displays shared text as static text and areas of difference in highlighted regions. When a user selects of a given area of difference, the text variations and a list of documents containing one or more corresponding text variations are displayed in a second panel.

Abstract: Provided herein is a disinfecting device including a container containing a chlorhexidine-based solution having a chlorhexidine concentration of from 0.2-2.0% wt/vol. Provided also is a medical connector disinfected with the disinfecting device. A method of disinfecting a medical connector using the disinfecting device is also disclosed.

Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: An architecture to provision one-stop parking, charging, storage, and/or maintenance facilities and/or functionalities for drone equipment. A method can comprise identifying a drone entering a defined airspace monitored by the network equipment; in response to establishing a communication channel with the drone, receiving data representing a physical dimension associated with the drone; based on the physical dimension associated with the drone, allocating a space within a defined area to which the drone is to navigate and then cease moving; and sending, to the drone via the communication channel, notification data that notifies the drone to navigate to the space.

Abstract: Systems and methods for using high-impact fasteners to couple components of a solar power system together to prevent these components from any movement or slippage relative to each other. A strap may be secured over a top surface of the high-impact fasteners and around the components to prevent a disengagement of the high-impact fastener from the components and a separation of the components.

Abstract: The present disclosure provides chimeric anti-gen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens, and polynucleotides encoding for the same. The present disclosure also provides for engineered cells expressing the poly-nucleotide or polypeptides. In some embodiments, the disclosure provides methods for treating diseases associated with CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens.

Abstract: Cable assemblies for providing electrical communication between hinged sections of an electronic device are described. The cable assemblies can include a cover that covers one or more cables that run through a hinge region of the electronic device. The cable and cover can be drawn over a mandrel of the hinge region. The cover and the portions of the mandrel can be visible to a user at the hinge region of the electronic device. The cover can be sufficiently rigid to guide a path of the cable and protect the cable from bending beyond a prescribed angle during rotation of the electronic device at the hinge region. The cover can also be sufficiently rigid to prevent ceasing or folding of the cover and the cable during rotation of the electronic device at the hinge region.

Abstract: A method of operating an engine is provided. An exhaust valve actuation fault is detected for a first exhaust valve associated with a first cylinder during a first working cycle. In response to the detection of the exhaust valve actuation fault, fueling to at least the first cylinder is cut off. Actuation of the first exhaust valve is attempted in second working cycles that follow the first working cycle, wherein the second working cycles are not fueled. Whether or not the first exhaust valve actuated properly during the second working cycles is determined. Operation of the first cylinder is resumed when it is determined that the first exhaust valve actuated properly. Operation of the first cylinder is not resumed when it is determined that the first exhaust valve did not actuate properly.

Abstract: A method for configuring a user device to which a plurality of identifiers, each uniquely identifying the user in at least one communications network, is allocated. The method includes, for at least one application: obtaining at least one rule associating, with at least one flow of the application, at least one slice of the at least one communications network for routing data relating to the at least one flow and an item of information connecting the slice to an identifier from among the plurality of identifiers of the user; and configuring the user device with the at least one rule such that it executes the at least one rule when accessing the application.

Abstract: Methods and apparatus for forming a reverse selective etch stop layer are disclosed. Some embodiments of the disclosure provide interconnects with lower resistance than methods which utilize non-selective (e.g., blanket) etch stop layers. Some embodiments of the disclosure utilize reverse selective etch stop layers within a subtractive etch scheme. Some embodiments of the disclosure selectively deposit the etch stop layer by passivating the surface of the metal material.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to natural killer (NK) cells. The invention also includes multimeric binding complexes comprising at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands or said multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by natural killer (NK) cells, such as inflammatory disorders, autoimmune disease and cancer.

Abstract: An apparatus to facilitate hardware enhancements for double precision systolic support is disclosed. The apparatus includes matrix acceleration hardware having double-precision (DP) matrix multiplication circuitry including a multiplier circuits to multiply pairs of input source operands in a DP floating-point format; adders to receive multiplier outputs from the multiplier circuits and accumulate the multiplier outputs in a high precision intermediate format; an accumulator circuit to accumulate adder outputs from the adders with at least one of a third global source operand on a first pass of the DP matrix multiplication circuitry or an intermediate result from the first pass on a second pass of the DP matrix multiplication circuitry, wherein the accumulator circuit to generate an accumulator output in the high precision intermediate format; and a down conversion and rounding circuit to down convert and round an output of the second pass as final result in the DP floating-point format.

Abstract: An apparatus to facilitate single precision support for systolic pipeline in a graphics environment is disclosed. The apparatus includes a processor comprising systolic array hardware including a plurality of data processing units, wherein the systolic array hardware is to: receive data for performance of a matrix multiplication operation in a first precision format; convert an original value of the data into two split values with a second precision format having a lower precision than the first precision format; perform the matrix multiplication operation using the two split values in the second precision format, the matrix multiplication operation comprising a split-term operation that utilizes two passes through the systolic array hardware with feedback wiring and local reduction; and generate an emulated result for the matrix multiplication operation in the first precision format.

Abstract: One embodiment provides an apparatus comprising a memory stack including multiple memory dies and a parallel processor including a plurality of multiprocessors. Each multiprocessor has a single instruction, multiple thread (SIMT) architecture, the parallel processor coupled to the memory stack via one or more memory interfaces. At least one multiprocessor comprises a multiply-accumulate circuit to perform multiply-accumulate operations on matrix data in a stage of a neural network implementation to produce a result matrix comprising a plurality of matrix data elements at a first precision, precision tracking logic to evaluate metrics associated with the matrix data elements and indicate if an optimization is to be performed for representing data at a second stage of the neural network implementation, and a numerical transform unit to dynamically perform a numerical transform operation on the matrix data elements based on the indication to produce transformed matrix data elements at a second precision.

Abstract: Among the various aspects of the present disclosure is the provision of treatments, monitoring treatment or progression, or methods for detecting utDNA in a subject having or suspected of having a urinary tract-associated cancer.

Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, recombinant polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides recombinant polymerases that yield lower systematic error rates and/or improved accuracy, when used in sequencing by synthesis reactions as compared to a control polymerase. In one aspect, the disclosure relates to recombinant polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In another aspect, the recombinant polymerases are useful for the amplification of nucleic acid templates during PCR, emPCR, isothermal amplification, recombinase polymerase amplification, rolling circle amplification, strand displacement amplification and proximity ligation amplification.

Abstract: An apparatus to facilitate supporting vector multiply add with double accumulator access in a graphics environment is disclosed. The apparatus includes a processor comprising processing resources, the processing resources comprising multiplier circuitry to: receive operands for a matrix multiplication operation, wherein the operands comprising two source matrices to be multiplied as part of the matrix multiplication operation; and issue a multiply and add vector (MADV) instruction for the multiplication operation utilizing a double accumulator access output, wherein the MADV instruction to multiply two vectors of the two source matrices in a single floating point (FP) pipeline of the processor.