Abstract: The present disclosure relates to compounds of Formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.

Abstract: A variable displacement axial piston pump (11) having a tiltable swashplate (33) to vary pump displacement by a manual input lever (43). The pump includes a neutral centering device (45) in which a cam member (57) is fixed to the end of one trunnion member (35). The cam member (57) defines three cam surfaces (65), each having a minimum displacement portion (67) and at least one maximum displacement portion (69). In engagement with each of the cam surfaces (65) is a follower element (79) supported by a cam follower holder (73), both of which are biased by a set of Belleville washers (75), toward the cam member (57). The present invention provides a neutral centering device which is balanced and simple to assemble, not requiring any special fixtures or holders for preloading a biasing spring, but which is able to provide a substantially constant return torque.