Patents by Inventor Kevin E. McBride
Kevin E. McBride has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20150184169Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: ApplicationFiled: March 6, 2015Publication date: July 2, 2015Inventors: MICHAEL LASSNER, Loren L Looger, Kevin E McBride, Brian McGonigle
-
Patent number: 8993315Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: GrantFiled: October 22, 2009Date of Patent: March 31, 2015Assignees: E I du Pont de Nemours and Company, Pioneer Hi-Bred International IncInventors: Michael Lassner, Loren L. Looger, Kevin E. McBride, Brian McGonigle
-
Patent number: 8877503Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: GrantFiled: May 13, 2011Date of Patent: November 4, 2014Assignees: E. I. du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.Inventors: Michael Lassner, Loren L. Looger, Kevin E. McBride, Brian McGonigle
-
Publication number: 20140243203Abstract: Compositions and methods relating to the use of sulfonylurea-mediated control of gene expression are provided. Compositions include sulfonylurea responsive chemical switches wherein the gene expression is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to regulate expression of a polynucleotide of interest in a cell or organism, and methods to modify a genome, including in a plant or plant cell.Type: ApplicationFiled: February 27, 2014Publication date: August 28, 2014Applicants: PIONEER HI-BRED INTERNATIONAL INC, E I DU PONT DE NEMOURS AND COMPANYInventors: JIN FANG, William Gordon-Kamm, Keith Lowe, Kevin E. McBride, Brian McGonigle, Carl Simmons
-
Publication number: 20140157453Abstract: Compositions and methods are provided for the introduction and the regulated expression of genes in plants. Compositions include promoter constructs that provide a level of activity useful for the regulated expression of site-specific recombinases, while avoiding premature excision. Further provided are isolated polynucleotides encoding novel babyboom polypeptides, expression cassettes, and plants comprising the same. Methods for the introduction of genes into plants are provided, including methods for plastid transformation and methods for the transformation of tissues from mature seeds and leaves.Type: ApplicationFiled: November 22, 2013Publication date: June 5, 2014Applicants: E.I. DUPONT DE NEMOURS, PIONEER HI BRED INTERNATIONAL INCInventors: WILLIAM JAMES GORDON-KAMM, THEODORE MITCHELL KLEIN, KEITH S. LOWE, KEVIN E. MCBRIDE, CHRISTOPHER JAY SCELONGE, NING WANG
-
Publication number: 20140033371Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: ApplicationFiled: October 3, 2013Publication date: January 30, 2014Applicants: PIONEER HI-BRED INTERNATIONAL INC, E I DU PONT DE NEMOURS AND COMPANYInventors: KEVIN E. MCBRIDE, MICHAEL W. LASSNER, LOREN L. LOOGER, BRIAN MCGONIGLE
-
Patent number: 8580556Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: GrantFiled: August 1, 2012Date of Patent: November 12, 2013Assignees: E. I. du Pont de Nemours and Company, Pioneer Hi-Bred International Inc.Inventors: Kevin E McBride, Michael W Lassner, Loren L Looger, Brian McGonigle
-
Patent number: 8575433Abstract: The present invention provides insecticidal polypeptides related to shuffled Bacillus thuringiensis Cry1 polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the polypeptides and nucleic acids of the invention to enhance resistance of plants to insect predation are encompassed.Type: GrantFiled: July 23, 2009Date of Patent: November 5, 2013Assignee: Pioneer Hi Bred International IncInventors: David Cerf, Ruth Cong, Michael Freeman, Kevin E. McBride, Takashi Yamamoto
-
Patent number: 8530411Abstract: The present invention provides insecticidal polypeptides related to shuffled Bacillus thuringiensis Cry1 polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the polypeptides and nucleic acids of the invention to enhance resistance of plants to insect predation are encompassed.Type: GrantFiled: April 14, 2009Date of Patent: September 10, 2013Assignee: Pioneer Hi-Bred International, Inc.Inventors: David Cerf, Ruth Cong, Michael Freeman, Kevin E. McBride, Takashi Yamamoto
-
Publication number: 20120295354Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: ApplicationFiled: August 1, 2012Publication date: November 22, 2012Applicant: E. I. DU PONT DE NEMOURS AND COMPANY AND PIONEER HI-BRED INTERNATIONALInventors: Kevin E. McBride, Michael Lassner, Loren L. Looger, Brian McGonigle
-
Patent number: 8257956Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: GrantFiled: October 22, 2009Date of Patent: September 4, 2012Assignees: E. I. du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.Inventors: Michael Lassner, Loren L. Looger, Kevin E. McBride, Brian McGonigle
-
Publication number: 20110294216Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: ApplicationFiled: October 22, 2009Publication date: December 1, 2011Applicants: E.I. duPont de Nemours and Company, Pioneer Hi-Bred International ,Inc.Inventors: Michael Lassner, Loren L. Looger, Kevin E. McBride, Brian McGonigle
-
Publication number: 20110287936Abstract: Compositions and methods relating to the use of sulfonylurea-mediated control of gene expression are provided. Compositions include sulfonylurea responsive chemical switches wherein the gene expression is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to regulate expression of a polynucleotide of interest in a cell or organism, and methods to modify a genome, including in a plant or plant cell.Type: ApplicationFiled: April 14, 2011Publication date: November 24, 2011Applicants: E.I. duPont de Nemours and Company, Pioneer Hi-Bred International, Inc.Inventors: Jin Fang, William J. Gordon-Kamm, Keith S. Lowe, Kevin E. McBride, Brian McGonigle, Carl R. Simmons
-
Publication number: 20110212838Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: ApplicationFiled: May 13, 2011Publication date: September 1, 2011Applicants: Pioneer Hi-Bred International, Inc., E.I. duPont de Nemours and CompanyInventors: Michael Lassner, Loren L. Looger, Kevin E. McBride, Brian McGonigle
-
Publication number: 20110167516Abstract: Compositions and methods are provided for the introduction and the regulated expression of genes in plants. Compositions include promoter constructs that provide a level of activity useful for the regulated expression of site-specific recombinases, while avoiding premature excision. Further provided are isolated polynucleotides encoding novel babyboom polypeptides, expression cassettes, and plants comprising the same. Methods for the introduction of genes into plants are provided, including methods for plastid transformation and methods for the transformation of tissues from mature seeds and leaves.Type: ApplicationFiled: December 30, 2010Publication date: July 7, 2011Applicant: Pioneer Hi-Bred International, Inc.Inventors: William J. Gordon-Kamm, Theodore M. Klein, Keith S. Lowe, Kevin E. McBride, Christopher J. Scelonge, Bing-Bing Wang, Ning Wang, Xinli E. Wu
-
Publication number: 20110055968Abstract: The present invention provides insecticidal polypeptides related to shuffled Bacillus thuringiensis Cry1 polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the polypeptides and nucleic acids of the invention to enhance resistance of plants to insect predation are encompassed.Type: ApplicationFiled: July 23, 2009Publication date: March 3, 2011Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: DAVID CERF, RUTH CONG, MICHAEL FREEMAN, KEVIN E. McBRIDE, TAKASHI YAMAMOTO
-
Publication number: 20100105141Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: ApplicationFiled: October 22, 2009Publication date: April 29, 2010Applicant: Pioneer Hi-Bred International, Inc.Inventors: Kevin E. McBride, Michael Lassner, Loren L. Looger, Brian McGonigle
-
Publication number: 20090226998Abstract: The present invention provides insecticidal polypeptides related to shuffled Bacillus thuringiensis Cry1 polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the polypeptides and nucleic acids of the invention to enhance resistance of plants to insect predation are encompassed.Type: ApplicationFiled: April 14, 2009Publication date: September 10, 2009Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: DAVID CERF, RUTH CONG, MICHAEL FREEMAN, KEVIN E. McBRIDE, TAKASHI YAMAMOTO
-
Publication number: 20090067700Abstract: A user may be provided with identified regions of interest superimposed on a larger image, which may permit the user to individually examine the regions of interest. The regions of interest may be independently windowed and/or leveled and/or magnified according to parameters associated with the region of interest, which parameters may be generated by a computer-aided detection algorithm.Type: ApplicationFiled: November 9, 2007Publication date: March 12, 2009Applicant: Riverain Medical Group, LLCInventors: Peter Maton, Bruce Voorhees, Arghir Suciu, Steve W. Worrell, Sam D. Finkelstein, David S. Fryd, Kevin E. McBride
-
Patent number: 7202085Abstract: DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (“lux box”) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.Type: GrantFiled: June 3, 2005Date of Patent: April 10, 2007Assignee: Calgene LLCInventors: Tim N. Oulmassov, Kevin E. McBride, Paula C. Miller, John C. Anderson, Lyle D. Crossland, Thomas H. Adams, Barbara A. Qurollo, Victoria Gavrias