Patents by Inventor Kevin E. McBride

Kevin E. McBride has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150184169
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Application
    Filed: March 6, 2015
    Publication date: July 2, 2015
    Inventors: MICHAEL LASSNER, Loren L Looger, Kevin E McBride, Brian McGonigle
  • Patent number: 8993315
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: March 31, 2015
    Assignees: E I du Pont de Nemours and Company, Pioneer Hi-Bred International Inc
    Inventors: Michael Lassner, Loren L. Looger, Kevin E. McBride, Brian McGonigle
  • Patent number: 8877503
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: November 4, 2014
    Assignees: E. I. du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.
    Inventors: Michael Lassner, Loren L. Looger, Kevin E. McBride, Brian McGonigle
  • Publication number: 20140243203
    Abstract: Compositions and methods relating to the use of sulfonylurea-mediated control of gene expression are provided. Compositions include sulfonylurea responsive chemical switches wherein the gene expression is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to regulate expression of a polynucleotide of interest in a cell or organism, and methods to modify a genome, including in a plant or plant cell.
    Type: Application
    Filed: February 27, 2014
    Publication date: August 28, 2014
    Applicants: PIONEER HI-BRED INTERNATIONAL INC, E I DU PONT DE NEMOURS AND COMPANY
    Inventors: JIN FANG, William Gordon-Kamm, Keith Lowe, Kevin E. McBride, Brian McGonigle, Carl Simmons
  • Publication number: 20140157453
    Abstract: Compositions and methods are provided for the introduction and the regulated expression of genes in plants. Compositions include promoter constructs that provide a level of activity useful for the regulated expression of site-specific recombinases, while avoiding premature excision. Further provided are isolated polynucleotides encoding novel babyboom polypeptides, expression cassettes, and plants comprising the same. Methods for the introduction of genes into plants are provided, including methods for plastid transformation and methods for the transformation of tissues from mature seeds and leaves.
    Type: Application
    Filed: November 22, 2013
    Publication date: June 5, 2014
    Applicants: E.I. DUPONT DE NEMOURS, PIONEER HI BRED INTERNATIONAL INC
    Inventors: WILLIAM JAMES GORDON-KAMM, THEODORE MITCHELL KLEIN, KEITH S. LOWE, KEVIN E. MCBRIDE, CHRISTOPHER JAY SCELONGE, NING WANG
  • Publication number: 20140033371
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Application
    Filed: October 3, 2013
    Publication date: January 30, 2014
    Applicants: PIONEER HI-BRED INTERNATIONAL INC, E I DU PONT DE NEMOURS AND COMPANY
    Inventors: KEVIN E. MCBRIDE, MICHAEL W. LASSNER, LOREN L. LOOGER, BRIAN MCGONIGLE
  • Patent number: 8580556
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: November 12, 2013
    Assignees: E. I. du Pont de Nemours and Company, Pioneer Hi-Bred International Inc.
    Inventors: Kevin E McBride, Michael W Lassner, Loren L Looger, Brian McGonigle
  • Patent number: 8575433
    Abstract: The present invention provides insecticidal polypeptides related to shuffled Bacillus thuringiensis Cry1 polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the polypeptides and nucleic acids of the invention to enhance resistance of plants to insect predation are encompassed.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: November 5, 2013
    Assignee: Pioneer Hi Bred International Inc
    Inventors: David Cerf, Ruth Cong, Michael Freeman, Kevin E. McBride, Takashi Yamamoto
  • Patent number: 8530411
    Abstract: The present invention provides insecticidal polypeptides related to shuffled Bacillus thuringiensis Cry1 polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the polypeptides and nucleic acids of the invention to enhance resistance of plants to insect predation are encompassed.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: September 10, 2013
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: David Cerf, Ruth Cong, Michael Freeman, Kevin E. McBride, Takashi Yamamoto
  • Publication number: 20120295354
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Application
    Filed: August 1, 2012
    Publication date: November 22, 2012
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY AND PIONEER HI-BRED INTERNATIONAL
    Inventors: Kevin E. McBride, Michael Lassner, Loren L. Looger, Brian McGonigle
  • Patent number: 8257956
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: September 4, 2012
    Assignees: E. I. du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.
    Inventors: Michael Lassner, Loren L. Looger, Kevin E. McBride, Brian McGonigle
  • Publication number: 20110294216
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Application
    Filed: October 22, 2009
    Publication date: December 1, 2011
    Applicants: E.I. duPont de Nemours and Company, Pioneer Hi-Bred International ,Inc.
    Inventors: Michael Lassner, Loren L. Looger, Kevin E. McBride, Brian McGonigle
  • Publication number: 20110287936
    Abstract: Compositions and methods relating to the use of sulfonylurea-mediated control of gene expression are provided. Compositions include sulfonylurea responsive chemical switches wherein the gene expression is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to regulate expression of a polynucleotide of interest in a cell or organism, and methods to modify a genome, including in a plant or plant cell.
    Type: Application
    Filed: April 14, 2011
    Publication date: November 24, 2011
    Applicants: E.I. duPont de Nemours and Company, Pioneer Hi-Bred International, Inc.
    Inventors: Jin Fang, William J. Gordon-Kamm, Keith S. Lowe, Kevin E. McBride, Brian McGonigle, Carl R. Simmons
  • Publication number: 20110212838
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Application
    Filed: May 13, 2011
    Publication date: September 1, 2011
    Applicants: Pioneer Hi-Bred International, Inc., E.I. duPont de Nemours and Company
    Inventors: Michael Lassner, Loren L. Looger, Kevin E. McBride, Brian McGonigle
  • Publication number: 20110167516
    Abstract: Compositions and methods are provided for the introduction and the regulated expression of genes in plants. Compositions include promoter constructs that provide a level of activity useful for the regulated expression of site-specific recombinases, while avoiding premature excision. Further provided are isolated polynucleotides encoding novel babyboom polypeptides, expression cassettes, and plants comprising the same. Methods for the introduction of genes into plants are provided, including methods for plastid transformation and methods for the transformation of tissues from mature seeds and leaves.
    Type: Application
    Filed: December 30, 2010
    Publication date: July 7, 2011
    Applicant: Pioneer Hi-Bred International, Inc.
    Inventors: William J. Gordon-Kamm, Theodore M. Klein, Keith S. Lowe, Kevin E. McBride, Christopher J. Scelonge, Bing-Bing Wang, Ning Wang, Xinli E. Wu
  • Publication number: 20110055968
    Abstract: The present invention provides insecticidal polypeptides related to shuffled Bacillus thuringiensis Cry1 polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the polypeptides and nucleic acids of the invention to enhance resistance of plants to insect predation are encompassed.
    Type: Application
    Filed: July 23, 2009
    Publication date: March 3, 2011
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: DAVID CERF, RUTH CONG, MICHAEL FREEMAN, KEVIN E. McBRIDE, TAKASHI YAMAMOTO
  • Publication number: 20100105141
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Application
    Filed: October 22, 2009
    Publication date: April 29, 2010
    Applicant: Pioneer Hi-Bred International, Inc.
    Inventors: Kevin E. McBride, Michael Lassner, Loren L. Looger, Brian McGonigle
  • Publication number: 20090226998
    Abstract: The present invention provides insecticidal polypeptides related to shuffled Bacillus thuringiensis Cry1 polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the polypeptides and nucleic acids of the invention to enhance resistance of plants to insect predation are encompassed.
    Type: Application
    Filed: April 14, 2009
    Publication date: September 10, 2009
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: DAVID CERF, RUTH CONG, MICHAEL FREEMAN, KEVIN E. McBRIDE, TAKASHI YAMAMOTO
  • Publication number: 20090067700
    Abstract: A user may be provided with identified regions of interest superimposed on a larger image, which may permit the user to individually examine the regions of interest. The regions of interest may be independently windowed and/or leveled and/or magnified according to parameters associated with the region of interest, which parameters may be generated by a computer-aided detection algorithm.
    Type: Application
    Filed: November 9, 2007
    Publication date: March 12, 2009
    Applicant: Riverain Medical Group, LLC
    Inventors: Peter Maton, Bruce Voorhees, Arghir Suciu, Steve W. Worrell, Sam D. Finkelstein, David S. Fryd, Kevin E. McBride
  • Patent number: 7202085
    Abstract: DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (“lux box”) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: April 10, 2007
    Assignee: Calgene LLC
    Inventors: Tim N. Oulmassov, Kevin E. McBride, Paula C. Miller, John C. Anderson, Lyle D. Crossland, Thomas H. Adams, Barbara A. Qurollo, Victoria Gavrias