Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for implementing a health monitoring system for a cloud application platform. One of the methods includes deploying, by a health monitoring application of a cloud application platform that provisions resources from an underlying cloud infrastructure system, probes for testing components of the cloud application platform. Each probe is configured to perform tests that measure performance of a component of the cloud application platform. A probe can attempt to provision resources from the underlying cloud infrastructure system by launching a test application on the cloud application platform and determine whether the test application launched successfully using resources from the underlying cloud infrastructure system.

Abstract: A production control platform is disclosed. The production control platform may gather information related to material produced from multiple production sources or related to a production destination that implements a production process to process the material. The production control platform may process the information to identify different possible combinations of respective outputs for the multiple production sources. The production control platform may determine a production source, of the multiple production sources, that limits input to the production process. The production control platform may determine a respective output for the multiple production sources. The production control platform may perform a set of actions related to causing the multiple production sources to produce the respective output.

Abstract: A production control platform is disclosed. The production control platform may gather information related to material produced from multiple production sources or related to a production destination that implements a production process to process the material. The production control platform may process the information to identify different possible combinations of respective outputs for the multiple production sources. The production control platform may determine a production source, of the multiple production sources, that limits input to the production process. The production control platform may determine a respective output for the multiple production sources. The production control platform may perform a set of actions related to causing the multiple production sources to produce the respective output.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for implementing a health monitoring system for a cloud application platform. One of the methods includes deploying, by a health monitoring application of a cloud application platform that provisions resources from an underlying cloud infrastructure system, probes for testing components of the cloud application platform. Each probe is configured to perform tests that measure performance of a component of the cloud application platform. A probe can attempt to provision resources from the underlying cloud infrastructure system by launching a test application on the cloud application platform and determine whether the test application launched successfully using resources from the underlying cloud infrastructure system.

Abstract: A method for operating a computer as a support vector machine (SVM) in order to define a decision surface separating two opposing classes of a training set of vectors. The method involves associating a distance parameter with each vector of the SVM's training set. The distance parameter indicates a distance from its associated vector, being in a first class, to the opposite class. A number of approaches to calculating distance parameters are provided. For example, a distance parameter may be calculated as the average of the distances from its associated vector to each of the vectors in the opposite class. The method further involves determining a linearly independent set of support vectors from the training set such that the sum of the distances associated with the linearly independent support vectors is minimised.