Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.

Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

Abstract: An intake manifold assembly for storage tanks comprises a pair of fill tubes joined together in side-by-side relation to a common mounting plate with spring latches at opposite ends of the mounting plate for releasable connection to an inlet on the tank such that the fill tubes are mounted at a predetermined angle to the inlet, a float assembly is attached to the manifold assembly to measure the liquid level in the tank, and a net assembly extends over the inlet to prevent entry of foreign matter into the tank.

Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

Abstract: The invention provides a family of fluorescent compounds. The compounds are substituted silaxanthenium compounds that can be chemically linked to one or more biomolecules, such as a protein, nucleic acid, and therapeutic small molecule. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications. The dyes are particularly useful for in vitro, in vivo and ex vivo imaging applications.

Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

Abstract: A system for determining at least one characteristic of wood furnish from an upstream source. The system includes: an inclined panel comprising a transparent window having a top surface for the wood furnish to slide down; a lighting means adjacent the transparent window for lighting the wood furnish visible through a bottom surface of the window; an image capturing means adjacent the transparent window for capturing an image of the wood furnish visible through the bottom surface of the window; and a processing means in communication with the image capturing means for deriving from the captured images the at least one characteristic of the wood furnish.

Abstract: The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

Abstract: The present invention relates to methods and compositions for increasing insulin sensitivity comprising the administration of anti-oxidized LDL antibodies.

Abstract: This invention relates to new carbocyanine fluorophores comprising a biomolecule targeting moiety containing 1-6 aromatic moieties, wherein the targeting moiety is designed to attach to biocompatible molecules to form in vivo optical imaging agents.

Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

Abstract: A system for determining at least one characteristic of wood furnish from an upstream source. The system includes: an inclined panel comprising a transparent window having a top surface for the wood furnish to slide down; a lighting means adjacent the transparent window for lighting the wood furnish visible through a bottom surface of the window; an image capturing means adjacent the transparent window for capturing an image of the wood furnish visible through the bottom surface of the window; and a processing means in communication with the image capturing means for deriving from the captured images the at least one characteristic of the wood furnish.

Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.

Abstract: This invention relates to new fluorescent chemical entities that are designed to attach to biocompatible molecules to form in vivo optical imaging agents.

Abstract: The invention relates to highly fluorescent metal oxide nanoparticles to which biomolecules and other compounds can be chemically linked to form biocompatible, stable optical imaging agents for in vitro and in vivo applications. The fluorescent metal oxide nanoparticles may also be used for magnetic resonance imaging (MRI), thus providing a multi modality imaging agent.

Abstract: The invention features biocompatible fluorescent nanoparticle and their use in in vivo imaging methods.

Abstract: A cutting die head that can be set and/or reset without an external mechanism. To this end, the die head includes a die body including a plurality of radially adjustable blocks, each block having a cutter mounted thereon and a radially outwardly facing cam surface. A sleeve surrounds the die body and has an inner surface. The inner surface has a plurality of cam surfaces arranged to communicate with the cam surfaces of the blocks such that axial movement of the sleeve results in radial movement of the blocks. In one embodiment the sleeve is caused to move axially by fluid pressure.

Abstract: Disclosed is a method and system for sorting a plurality of green wood veneer sheets into a plurality of subsets of sheets, the subsets including a “driest” subset, a “wettest” subset, and one or more “intermediate” subsets. The system has a light source for transmitting light through a sheet of veneer as it passes along a conveyor system, and a light sensor for sensing the light passing through the sheet. The pattern of light is recorded by an image acquisition and processing subsystem as an image, which is fed to an image analysis subsystem programmed to analyse the light pattern and to produce a mathematical representation of the image. An integrated moisture content value (IMCV) is set for the particular veneer sheet. Based on this value, a controller sends signals to the conveyor system to convey the particular sheet to a location storing sheets having similar IMCV values for drying.

Abstract: Disclosed is a method and system for sorting a plurality of green wood veneer sheets into a plurality of subsets of sheets, the subsets including a “driest” subset, a “wettest” subset, and one or more “intermediate” subsets. The system has a light source for transmitting light through a sheet of veneer as it passes along a conveyor system, and a light sensor for sensing the light passing through the sheet. The pattern of light is recorded by an image acquisition and processing subsystem as an image, which is fed to an image analysis subsystem programmed to analyse the light pattern and to produce a mathematical representation of the image. An integrated moisture content value (IMCV) is set for the particular veneer sheet. Based on this value, a controller sends signals to the conveyor system to convey the particular sheet to a location storing sheets having similar IMCV values for drying.