Patents by Inventor Kevin J. Bitterman

Kevin J. Bitterman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR EXTENDING THE LIFE SPAN AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS
    Publication number: 20120022013
    Abstract: The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.
    Type: Application
    Filed: April 19, 2011
    Publication date: January 26, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: David A. Sinclair, Kevin J. Bitterman
  • Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
    Patent number: 7977049
    Abstract: The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.
    Type: Grant
    Filed: February 8, 2005
    Date of Patent: July 12, 2011
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Sinclair, Kevin J. Bitterman
  • COMPOSITIONS FOR MANIPULATING THE LIFESPAN AND STRESS RESPONSE OF CELLS AND ORGANISMS
    Publication number: 20100035885
    Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
    Type: Application
    Filed: June 8, 2009
    Publication date: February 11, 2010
    Applicants: President and Fellows of Harvard College, BIOMOL International L.P.
    Inventors: David A. Sinclair, Konrad T. Howitz, Robert E. Zipkin, Kevin J. Bitterman, Dudley W. Lamming
  • Compositions for manipulating the lifespan and stress response of cells and organisms
    Patent number: 7544497
    Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
    Type: Grant
    Filed: July 1, 2004
    Date of Patent: June 9, 2009
    Assignees: President and Fellows of Harvard College, Biomol International LP
    Inventors: David A. Sinclair, Konrad T. Howitz, Robert E. Zipkin, Kevin J. Bitterman, Dudley W. Lamming