Abstract: Automated cold storage unit and systems for storing, monitoring, and maintaining a supply of temperature sensitive pharmaceutical and/or other products in compliance with regulatory requirements are provided. Such units contain an array of independently addressable holding locations for containers with product in one or more controlled temperature zones fitted with temperature sensors. The units include a reader to track product information and status. Product movement within the unit is performed by a computer-controlled robot. A user interface device, preferably in communication with an application service provider to provide remotely managed inventory management and other services, provides users with secure access to the contents of the unit and associated product data and information.

Abstract: Cell assemblies and methods for assembling cell assemblies include installing a plurality of cells within a cell housing and electrically connecting each cell to each other cell through at least one wire bond, wherein each wire bond is selected to conduct current from a respective cell during normal operation and to sever such electrical connection through the wire bond when a predetermined current exceeds a threshold value for a predetermined period of time.

Abstract: A solenoid adapter for a solenoid valve that permits use of different solenoids with different solenoid bowls is provided. Specifically, a reverse flow solenoid adapter enables use of a reverse flow solenoid with a forward flow solenoid bowl, while a forward flow solenoid adapter enables use of a forward flow solenoid with a reverse flow solenoid bowl. The adapters include a lower section to mount into a valve solenoid bowl, an upper portion including an adapter solenoid chamber to receive a solenoid, and flow-reversing passages that duct a vent passage flow path from the valve solenoid bowl to the adapter solenoid chamber such that the flow path transitions from a flow configuration of the valve solenoid bowl to a flow configuration required for the solenoid to function and returns to the flow configuration of the valve solenoid bowl as the path circulates back to the valve solenoid bowl.

Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: A rotor lock assembly for locking a rotor of a wind turbine. The rotor lock assembly has at least one relocatable rotor lock. The relocatable rotor lock has a housing, a bushing element, a pin shaft position within the bushing element, and a locking mechanism. The housing includes a mounting portion adapted for mounting to a bearing housing adjacent to a rotor lock plate of the rotor.

Abstract: This invention relates generally to compositions for making and administering anellovectors and uses thereof.

Abstract: A device for treating a tissue opening includes a proximal portion including an elongated flexible member, a capsule releasably coupled to a distal end of the flexible member and including a lumen extending therethrough and a clip including a pair of arms movably housed within the capsule. A suture extending along a first one of the pair of arms and including a loop at a distal end thereof extending across an opening extending through the first one of the pair of arms. A suture grabbing element extending laterally from a second one of the pair of arms and including a hook so that, when the pair of arms are moved toward a closed configuration, the hook extends through the opening to grab the loop and draw the distal end of the suture from the first one of the pair of arms toward the second one of the pair of arms.

Abstract: A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

Abstract: A heat exchanger includes an inlet for receiving bulk solids, a plurality of heat transfer plate assemblies, a plurality of spacers disposed between adjacent heat transfer plate assemblies, and supports for supporting the heat transfer plate assemblies. The heat transfer plate assemblies include a first plate having a first pair of holes extending therethrough, the first plate having channels extending along a surface thereof, for the flow of fluid through the channels, and a second plate bonded to the first plate to enclose the channels, the second plate including a second pair of holes generally aligned with the first pair of holes to form through holes to facilitate flow of the fluid through the through holes and the channels.

Abstract: Provided are a computer program product, system, and method for sorting documents according to comprehensibility scores determined for the documents. A document has sections of text associated with topics. A determination is made of familiarity scores for a user for the topics associated with the sections of text in the document. A determination is made of a comprehensibility score of the document, indicating comprehensibility of the document to the user, as a function of the determined familiarity scores for the topics in the document. The comprehensibility score for the document is used to determine an order in which to present the document to the user with a group of documents.

Abstract: A valve and tether fixation mechanism includes an anchor, a tether, and a prosthetic heart valve. The anchor may be for anchoring a prosthetic heart valve in a native heart valve. The tether may have a distal end coupled to the anchor. The tether may extend proximally from the anchor and connect to a tensioning mechanism. The prosthetic valve may be configured to translate along the tether. The valve may have a tether connecting portion configured to allow for adjustment of the tension in the tether and affix the prosthetic valve to the tether at a desired tension.

Abstract: Content is organized for brands by selecting a plurality of brand templates. After each selection, a set of properties is generated by applying a portion of settings of the respective brand template, with the remaining settings being overridden with settings for a channel communicating one of a plurality of presentations to a node of a network involved in the communication. The plurality of presentations may include different renditions of the same content. The properties may include sections configured for different focus areas and/or types of content associated with at tags to enable brand-level-targeting. Filters may be identified in the properties. Based on each of the identifications, a property from among the generated sets of properties may be selected based on comparisons with the associated tags.

Abstract: Methods, systems and apparatus for resetting a qubit. In one aspect, an apparatus includes a qubit, wherein the state of the qubit occupies a plurality of levels comprising two computational levels and one or more non-computational levels; a resonator that operates at a resonator frequency; control electronics that control a frequency of the qubit such that during a reset operation the qubit frequency is adjusted from a holding frequency that is lower than the resonator frequency to an idling frequency that is higher than the resonator frequency, and during the adjustment a first derivative of the qubit frequency at a first time is positive, at a second time that occurs after the first time is zero, and at a third time that occurs after the second time is positive, where the qubit frequency achieves the idling frequency at a fourth time that occurs after the third time.

Abstract: Examples of synchronization of a gyroscope in a virtual-reality (VR) environment are described. In some examples, gyroscopic feedback for VR application content may be predicted. In some examples, a time shift corresponding to a physical system lag of a gyroscope may be added to synchronize the gyroscopic feedback with the VR application content. In some examples, the gyroscopic feedback may be applied based on the time shift.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: Energy is transmitted to a body lumen or passageway in the form of pulsed electric fields (PEFs) and in a manner which provides focal therapy. In some embodiments, PEFs are delivered through independent electrically active electrodes of an energy delivery body, typically in a monopolar fashion. Such delivery concentrates the electrical energy over a smaller surface area, resulting in stronger effects than delivery through an electrode extending circumferentially around the lumen or passageway. It also forces the electrical energy to be delivered in a staged regional approach, mitigating the effect of preferential current pathways through the surrounding tissue. Focal delivery of PEFs can provide increased tissue lethality by employing precise timing and sequencing of energy delivery to the electrodes.

Abstract: An apparatus that forms bundles of glass articles includes a glass article infeed station including an infeed conveyor that continuously transports individual glass articles to a layer separating conveyor. The layer separating conveyor includes a conveyor belt that forms a layer of side-by-side glass articles. A robotic lift assembly is configured to place the layer of side-by-side glass articles together on a layer separation insert. The layer separation insert has side-by-side slots that each receive a single glass article of the layer of side-by-side glass articles.

Abstract: A system includes a first wellbore operation controller for controlling a wellbore operation and generating a first broadcast indicating a first data topic desired for controlling the wellbore operation. The system also includes a second wellbore operation controller for generating a data stream associated with a wellbore and for generating a second broadcast indicating a second data topic that promotes the data stream. The system includes a mediator computing device that receives the first broadcast and the second broadcast and determines that the first wellbore operation controller is subscribed to the data stream by comparing the first data topic to the second data topic. In response to determining that the first wellbore operation controller is subscribed to the data stream, the mediator computing device creates a data link between the first wellbore operation controller and the second wellbore operation controller.

Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.