Patents by Inventor Kevin Kelnar

Kevin Kelnar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic mimics of miR-124
    Patent number: 9611478
    Abstract: Embodiments concern methods and compositions involving miR-124 mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-124 sequence and a complementary passenger strand.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: April 4, 2017
    Assignee: MIRNA THERAPEUTICS, INC.
    Inventors: Kevin Kelnar, David Brown
  • COMBINATION CANCER TREATMENTS UTILIZING SYNTHETIC OLIGONUCLEOTIDES AND EGFR-TKI INHIBITORS
    Publication number: 20170035797
    Abstract: The disclosure provides methods and compositions for treating cancer cells, including cancer cells in a subject, whereby two or more therapeutic agents are used, one being an EGFR-TKI agent and the other being a synthetic oligonucleotide.
    Type: Application
    Filed: October 20, 2016
    Publication date: February 9, 2017
    Inventors: Andreas BADER, Jane ZHAO, Kevin KELNAR
  • METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
    Publication number: 20170037404
    Abstract: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
    Type: Application
    Filed: October 20, 2016
    Publication date: February 9, 2017
    Inventors: David BROWN, Lance FORD, Angie CHENG, Rich JARVIS, Mike BYROM, Dmitriy OVCHARENKO, Eric DEVROE, Kevin KELNAR
  • Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
    Patent number: 9540645
    Abstract: The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: January 10, 2017
    Assignees: The John Hopkins University, ASURAGEN, Inc.
    Inventors: Jikui Shen, Kevin Kelnar, Jeffrey Shelton, David Brown, Peter Campochiaro
  • Methods and compositions involving miRNA and miRNA inhibitor molecules
    Patent number: 9506061
    Abstract: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: November 29, 2016
    Assignee: ASURAGEN, INC.
    Inventors: David Brown, Lance Ford, Angie Cheng, Rich Jarvis, Mike Byrom, Dmitriy Ovcharenko, Eric Devroe, Kevin Kelnar
  • Methods and compositions involving miRNA and miRNA inhibitor molecules
    Patent number: 9447414
    Abstract: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: September 20, 2016
    Assignee: ASURAGEN, INC.
    Inventors: David Brown, Lance Ford, Angie Cheng, Rich Jarvis, Mike Byrom, Dmitriy Ovcharenko, Eric Devroe, Kevin Kelnar
  • COMPOSITIONS AND METHODS RELATED TO MIRNA MODULATION OF NEOVASCULARIZATION OR ANGIOGENESIS
    Publication number: 20160222385
    Abstract: The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.
    Type: Application
    Filed: April 19, 2016
    Publication date: August 4, 2016
    Inventors: Jikui SHEN, Kevin KELNAR, Jeffrey SHELTON, David BROWN, Peter CAMPOCHIARO
  • Methods and compositions involving miRNA and miRNA inhibitor molecules
    Patent number: 9382537
    Abstract: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: July 5, 2016
    Assignee: ASURAGEN, INC.
    Inventors: David Brown, Lance Ford, Angie Cheng, Rich Jarvis, Mike Byrom, Dmitriy Ovcharenko, Eric Devroe, Kevin Kelnar
  • Synthetic mimics of miR-34
    Patent number: 9371526
    Abstract: Embodiments concern methods and compositions involving miR-34 mimics, including miR-34a and miR-34c mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34a sequence and a complementary passenger strand. In additional embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34c sequence and a complementary passenger strand.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: June 21, 2016
    Assignee: Mirna Therapeutics, Inc.
    Inventors: Kevin Kelnar, David Brown
  • Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
    Patent number: 9365852
    Abstract: The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: June 14, 2016
    Assignee: MIRNA THERAPEUTICS, INC.
    Inventors: Jikui Shen, Kevin Kelnar, Jeffrey Shelton, David Brown, Peter Campochiaro
  • SYNTHETIC MIMICS OF MIR-124
    Publication number: 20160060629
    Abstract: Embodiments concern methods and compositions involving miR-124 mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-124 sequence and a complementary passenger strand.
    Type: Application
    Filed: November 11, 2015
    Publication date: March 3, 2016
    Inventors: Kevin KELNAR, David BROWN
  • SYNTHETIC MIMICS OF MIR-34
    Publication number: 20160053264
    Abstract: Embodiments concern methods and compositions involving miR-34 mimics, including miR-34a and miR-34c mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34a sequence and a complementary passenger strand. In additional embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34c sequence and a complementary passenger strand.
    Type: Application
    Filed: November 5, 2015
    Publication date: February 25, 2016
    Inventors: Kevin KELNAR, David BROWN
  • Synthetic mimics of MIR-124
    Patent number: 9222085
    Abstract: Embodiments concern methods and compositions involving miR-124 mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-124 sequence and a complementary passenger strand.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: December 29, 2015
    Assignee: MIRNA THERAPEUTICS, INC.
    Inventors: Kevin Kelnar, David Brown
  • METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
    Publication number: 20150361431
    Abstract: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
    Type: Application
    Filed: August 31, 2015
    Publication date: December 17, 2015
    Inventors: David BROWN, Lance FORD, Angie CHENG, Rich JARVIS, Mike BYROM, Dmitriy OVCHARENKO, Eric DEVROE, Kevin KELNAR
  • METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
    Publication number: 20150352046
    Abstract: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
    Type: Application
    Filed: June 16, 2015
    Publication date: December 10, 2015
    Inventors: David BROWN, Lance FORD, Angie CHENG, Rich JARVIS, Mike BYROM, Dmitriy OVCHARENKO, Eric DEVROE, Kevin KELNAR
  • METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
    Publication number: 20150344881
    Abstract: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
    Type: Application
    Filed: May 14, 2015
    Publication date: December 3, 2015
    Inventors: David BROWN, Lance FORD, Angie CHENG, Rich JARVIS, Mike BYROM, Dmitry OVCHARENKO, Eric DEVROE, Kevin KELNAR
  • COMPOSITIONS AND METHODS RELATED TO MIRNA MODULATION OF NEOVASCULARIZATION OR ANGIOGENESIS
    Publication number: 20150344880
    Abstract: The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.
    Type: Application
    Filed: May 5, 2015
    Publication date: December 3, 2015
    Inventors: Jikui SHEN, Kevin KELNAR, Jeffrey SHELTON, David BROWN, Peter CAMPOCHIARO
  • METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
    Publication number: 20150344883
    Abstract: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
    Type: Application
    Filed: June 12, 2015
    Publication date: December 3, 2015
    Inventors: David BROWN, Lance FORD, Angie CHENG, Rich JARVIS, Mike BYROM, Dmitriy OVCHARENKO, Eric DEVROE, Kevin KELNAR
  • METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
    Publication number: 20150342981
    Abstract: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
    Type: Application
    Filed: June 12, 2015
    Publication date: December 3, 2015
    Inventors: David BROWN, Lance FORD, Angie CHENG, Rich JARVIS, Mike BYROM, Dmitriy OVCHARENKO, Eric DEVROE, Kevin KELNAR
  • METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
    Publication number: 20150299705
    Abstract: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
    Type: Application
    Filed: June 12, 2015
    Publication date: October 22, 2015
    Inventors: David BROWN, Lance FORD, Angie CHENG, Rich JARVIS, Mike BYROM, Dmitriy OVCHARENKO, Eric DEVROE, Kevin KELNAR